DDR-TRK-1 (DDR1 inhibitor 6j)
- CAS No.
- 1934246-19-1
- Chemical Name:
- DDR-TRK-1 (DDR1 inhibitor 6j)
- Synonyms
- DDR-TRK-1;DDRTRK1,DDR TRK 1;DDR-TRK-1, 10 mM in DMSO;DDR-TRK-1 (DDR1 inhibitor 6j);7-Isoquinolinecarboxamide, 1,2,3,4-tetrahydro-4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-2-(5-pyrimidinyl)-, (4R)-
- CBNumber:
- CB24844697
- Molecular Formula:
- C26H23F3N6O
- Molecular Weight:
- 492.5
- MDL Number:
- MFCD30543426
- MOL File:
- 1934246-19-1.mol
- MSDS File:
- SDS
| Boiling point | 609.3±55.0 °C(Predicted) |
|---|---|
| Density | 1.37±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO |
| pka | 12.84±0.70(Predicted) |
| form | powder |
| color | white to beige |
| optical activity | [α]/D -25 to -20°, c =0.5 in methanol |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
DDR-TRK-1 (DDR1 inhibitor 6j) price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 41321 | DDR-TRK-1 ≥95% | 1934246-19-1 | 1mg | $43 | 2026-04-30 | Buy |
| Cayman Chemical | 41321 | DDR-TRK-1 ≥95% | 1934246-19-1 | 5mg | $161 | 2026-04-30 | Buy |
| Cayman Chemical | 41321 | DDR-TRK-1 ≥95% | 1934246-19-1 | 10mg | $301 | 2026-04-30 | Buy |
| Biosynth | JCD24619 | DDR-TRK-1 | 1934246-19-1 | 5mg | $1518.65 | 2026-06-04 | Buy |
| Biosynth | JCD24619 | DDR-TRK-1 | 1934246-19-1 | 10mg | $2429.9 | 2026-06-04 | Buy |
DDR-TRK-1 (DDR1 inhibitor 6j) Chemical Properties, Uses, Production
Uses
DDR-TRK-1 is a selective Discoidin Domain Receptor 1 (DDR1) inhibitor, with an IC50 value of 9.4 nM. DDR-TRK-1 also inhibits TRK family.
Biological Activity
DDR-TRK-1 was shown to inhibit the kinase activity of Discoidin Domain Receptor 1 (DDR1) with an IC50 value of 9.4 nM. DDR receptors are linked to the progression of various human diseases, including fibrotic disorders such as pulmonary fibrosis, as well as atherosclerosis and cancer. DDR-TRK-1 showed a therapeutic effect in a mouse model of pulmonary fibrosis and inhibited Panc-1 pancreatic cancer cell colony formation and migration. DDR-TRK-1 also inhibits the TRK family kinases TRKA, TRKB, and TRKC, which are selectively expressed in neuronal tissue. DDR-TRK-1N is the negative control compound.
in vivo
DDR-TRK-1 prevents these BLM-induced pathological changes in a dose-dependent manner. These results agree with the expression levels of fibrotic markers in lung tissue lysates, including fibronectin and α-smooth muscle actin (SMA). Further analyses also reveal that the administration of DDR-TRK-1 cause a dose-dependent suppression in the content of hydroxyproline, a unique amino acid found in collagen. The above data collectively indicate the promising therapeutic potential of DDR-TRK-1 against the BLM-induced pulmonary fibrosis[1].
References
[1] Zhen Wang, et al. Structure-Based Design of Tetrahydroisoquinoline-7-carboxamides as Selective Discoidin Domain Receptor 1 (DDR1) Inhibitors. J Med Chem. 2016 Jun 23; 59(12): 5911–5916. DOI:10.1021/acs.jmedchem.6b00140
DDR-TRK-1 (DDR1 inhibitor 6j) Preparation Products And Raw materials
Raw materials
Preparation Products
DDR-TRK-1 (DDR1 inhibitor 6j) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6288 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 | psaitong@jm-bio.com | China | 27626 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
| Beijing Boorsen Biotechnology Co., Ltd | 400-901-9800 18611424007 | cis@bioss.com.cn | China | 9185 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 025-85560043 15850508050 | cindy.huang@synzest.com | China | 11975 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| Shanghai Amole Biotechnology Co., Ltd. | 13370042665 18916960931 | 2596183085@qq.com | China | 17234 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 38999 | 58 |
