Propargyl-PEG8-NHS ester
- CAS No.
- 2182601-74-5
- Chemical Name:
- Propargyl-PEG8-NHS ester
- Synonyms
- Propargyl-PEG8-NHS ester;Propargyl-PEG7-CH2CH2COONHS;Propargyl-PEG7-C2-CONHS ester;2,5-Dioxopyrrolidin-1-yl 4,7,10,13,16,19,22,25-octaoxaoctacos-27-yn-1-oate;4,7,10,13,16,19,22,25-Octaoxaoctacos-27-ynoic acid, 2,5-dioxo-1-pyrrolidinyl ester;Propargyl-PEG7-CH2CH2COONHS/4,7,10,13,16,19,22,25-Octaoxaoctacos-27-ynoic acid, 2,5-dioxo-1-pyrrolidinyl ester
- CBNumber:
- CB24849485
- Molecular Formula:
- C24H39NO12
- Molecular Weight:
- 533.57
- MDL Number:
- MFCD31536764
- MOL File:
- 2182601-74-5.mol
Propargyl-PEG8-NHS ester price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| BroadPharm | BP-23778 | Propargyl-PEG8-NHSester 98% | 2182601-74-5 | 100mg | $320 | 2021-12-16 | Buy |
| Activate Scientific | AS107809 | Propargyl-PEG7-CH2CH2COONHS 97% | 2182601-74-5 | 250mg | $454 | 2021-12-16 | Buy |
| BroadPharm | BP-23778 | Propargyl-PEG8-NHSester 98% | 2182601-74-5 | 500mg | $720 | 2021-12-16 | Buy |
| Acrotein | B-1545 | Propargyl-PEG7-CH2CH2COONHS 97% | 2182601-74-5 | 0.25g | $315.33 | 2021-12-16 | Buy |
Propargyl-PEG8-NHS ester Chemical Properties,Uses,Production
Description
Propargyl-PEG8-NHS ester is an amine reactive compound with an alkyne group. The alkyne group reacts with azide-containing biomolecules in Click Chemistry reactions, copper is needed as a catalyst. The hydrophilic PEG units helps the compound to have better solubility in aqueous environment.
Biological Activity
Propargyl-PEG8-NHS ester is a PROTAC bridge, belonging to the PEG class and the Alkyl/ether class. It can be used to synthesize a range of PROTAC molecules. And it is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs).
in vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
target
| Cleavable
| PEGs
| Alkyl/ether
|
Propargyl-PEG8-NHS ester Preparation Products And Raw materials
Raw materials
Preparation Products
Propargyl-PEG8-NHS ester Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5738 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32268 | 58 |
| Wuhan Borenpharm Co., Ltd | 027-65563561 18717150066 | 3207347307@qq.com | CHINA | 1238 | 58 |
| Hangzhou Huarong Pharm Co., Ltd. | 571-86758373 +8613588754946 | sales@huarongpharm.com | CHINA | 3148 | 58 |
| Alfa Chemistry | Info@alfa-chemistry.com | United States | 24072 | 58 | |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38664 | 58 | |
| Jilin Chinese Academy of Sciences-yanshen Technology | +undefined18143011203 | info@chemextension.com | China | 42056 | 58 |
| Xian confluore Biological Technology Co., Ltd. | +86-15680926068 +86-15680926068 | 1924344760@confluore.cn | China | 2996 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| T&W GROUP | 021-61551611 13296011611 | contact@trustwe.com | China | 9895 | 58 |
View Lastest Price from Propargyl-PEG8-NHS ester manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-10-28 | Propargyl-PEG8-NHS ester
2182601-74-5
|
US $0.00 / mg | 10g | TargetMol Chemicals Inc. | |||
 |
2024-03-26 | Propargyl-PEG8-NHS ester
2182601-74-5
|
US $0.00 / g | 1g | >98.00% | 1g | Xian confluore Biological Technology Co., Ltd. |
-
- Propargyl-PEG8-NHS ester
2182601-74-5
- US $0.00 / mg
- TargetMol Chemicals Inc.
-
- Propargyl-PEG8-NHS ester
2182601-74-5
- US $0.00 / g
- >98.00%
- Xian confluore Biological Technology Co., Ltd.
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