Propargyl-PEG8-NHS ester
- CAS No.
- 2182601-74-5
- Chemical Name:
- Propargyl-PEG8-NHS ester
- Synonyms
- Alkyne-PEG8-NHS;Propargyl-PEG8-NHS;Propargyl-PEG8-NHS ester;Propargyl-PEG7-CH2CH2COONHS;Propargyl-PEG7-C2-CONHS ester;2,5-Dioxopyrrolidin-1-yl 4,7,10,13,16,19,22,25-octaoxaoctacos-27-yn-1-oate;4,7,10,13,16,19,22,25-Octaoxaoctacos-27-ynoic acid, 2,5-dioxo-1-pyrrolidinyl ester;Propargyl-PEG7-CH2CH2COONHS/4,7,10,13,16,19,22,25-Octaoxaoctacos-27-ynoic acid, 2,5-dioxo-1-pyrrolidinyl ester
- CBNumber:
- CB24849485
- Molecular Formula:
- C24H39NO12
- Molecular Weight:
- 533.57
- MDL Number:
- MFCD31536764
- MOL File:
- 2182601-74-5.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501 |
Propargyl-PEG8-NHS ester price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0107559 | Propargyl-PEG8-NHS ester ≥95% | 2182601-74-5 | 100mg | $37 | 2026-06-04 | Buy |
| ChemScene | CS-0107559 | Propargyl-PEG8-NHS ester ≥95% | 2182601-74-5 | 250mg | $45 | 2026-06-04 | Buy |
| ChemScene | CS-0107559 | Propargyl-PEG8-NHS ester ≥95% | 2182601-74-5 | 1g | $179 | 2026-06-04 | Buy |
| ChemScene | CS-0107559 | Propargyl-PEG8-NHS ester ≥95% | 2182601-74-5 | 5g | $627 | 2026-06-04 | Buy |
| BroadPharm | bp-23778 | Propargyl-PEG8-NHS ester 98% | 2182601-74-5 | 100MG | $320 | 2026-05-24 | Buy |
Propargyl-PEG8-NHS ester Chemical Properties, Uses, Production
Description
Propargyl-PEG8-NHS ester is an amine reactive compound with an alkyne group. The alkyne group reacts with azide-containing biomolecules in Click Chemistry reactions, copper is needed as a catalyst. The hydrophilic PEG units helps the compound to have better solubility in aqueous environment.
Biological Activity
Propargyl-PEG8-NHS ester is a PROTAC bridge, belonging to the PEG class and the Alkyl/ether class. It can be used to synthesize a range of PROTAC molecules. And it is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs).
in vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
target
| Cleavable
| PEGs
| Alkyl/ether
|
Propargyl-PEG8-NHS ester Preparation Products And Raw materials
Raw materials
Preparation Products
Propargyl-PEG8-NHS ester Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| T&W GROUP | 021-61551611 13296011611 | contact@trustwe.com | China | 9884 | 58 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd | 0431-80534353 19917294565 | et@chemextension.com | China | 3902 | 55 |
| Chengdu DingDang Pharmaceutical Co., Ltd. | 028-86040038 | market@dingdangchem.com | China | 1853 | 55 |
| Borenpharm Co., Ltd | 027-65563561 | sales@borenpharm.com | China | 1245 | 55 |
| Amatek Scientific Co. Ltd. | 0512-56316828 400-867-5858;400-867-5858 | info@amateksci.com | China | 28760 | 58 |
| Xi'an Confluore Biological Technology Co., Ltd. | +86-156-80926068 +86-15680926068 | 1924344760@qq.com | China | 4229 | 58 |
| Shanghai Jizhi Biochemical Technology Co. Ltd. | 021-4009004166/18616739031 18616739031 | 3007523370@qq.com | China | 40000 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Hangzhou Huarong Pharm Co., Ltd. | 571-86758373 +8613588754946 | sales@huarongpharm.com | CHINA | 3147 | 58 |
View Latest Price from Propargyl-PEG8-NHS ester manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-24 | Propargyl-PEG8-NHS
2182601-74-5
|
1g | 98% | 1g/bottle, 10g/bottle, 100g/bottle | XIAMEN SINOPEG BIOTECH CO., LTD. | ||
 |
2026-05-11 | Propargyl-PEG8-NHS ester
2182601-74-5
|
10g | TargetMol Chemicals Inc. | ||||
 |
2025-06-07 | Propargyl-PEG8-NHS ester
2182601-74-5
|
1g | >98.00% | 1g | Xian confluore Biological Technology Co., Ltd. |
-
- Propargyl-PEG8-NHS
2182601-74-5
- 98%
- XIAMEN SINOPEG BIOTECH CO., LTD.
-
- Propargyl-PEG8-NHS ester
2182601-74-5
- $0.00
- TargetMol Chemicals Inc.
-
- Propargyl-PEG8-NHS ester
2182601-74-5
- $0.00
- >98.00%
- Xian confluore Biological Technology Co., Ltd.
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