3-(2-Propynyloxy)propanoic acid
- CAS No.
- 55683-37-9
- Chemical Name:
- 3-(2-Propynyloxy)propanoic acid
- Synonyms
- Propargyl-PEG1-Acid;3-(Prop-2-yn-1-yloxy)propanoic acid;Alkyne-PEG1-COOH;Propargyl-PEG1-PA;Propargyl-PEG1-acid >=95%;3-prop-2-ynoxypropanoicaci;3-prop-2-ynoxypropanoic acid;Propargyl-PEG1-acid;3-(2-Propynyloxy)propanoic acid;3-(prop-2-ynyloxy)propanoic acid
- CBNumber:
- CB52175752
- Molecular Formula:
- C6H8O3
- Molecular Weight:
- 128.13
- MDL Number:
- MFCD10689189
- MOL File:
- 55683-37-9.mol
| Product description | Number | Pack Size | Price |
| Propargyl-PEG1-acid ≥95% | 901567 | 50MG | $99.36 |
| 3-(Prop-2-ynyloxy)propanoicAcid | P839730 | 10mg | $45 |
| Propargyl-PEG1-acid 98% | BP-21981 | 100mg | $120 |
| 3-(Prop-2-yn-1-yloxy)propanoicacid | 6811BA | 100mg | $143 |
| 3-(Prop-2-yn-1-yloxy)propanoicacid 97+% | AS116781 | 250mg | $210 |
| More product size | |||
| Boiling point | 265.8±20.0 °C(Predicted) |
|---|---|
| Density | 1.140±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| form | Liquid |
| pka | 4.19±0.10(Predicted) |
| color | Colorless to light yellow |
| InChI | InChI=1S/C6H8O3/c1-2-4-9-5-3-6(7)8/h1H,3-5H2,(H,7,8) |
| InChIKey | GMFDYXLFHSFUHE-UHFFFAOYSA-N |
| SMILES | C(O)(=O)CCOCC#C |
| UNSPSC Code | 12352106 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| WGK Germany | WGK 3 |
| Storage Class | 10 - Combustible liquids |
3-(2-Propynyloxy)propanoic acid price More Price(22)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 901567 | Propargyl-PEG1-acid ≥95% | 55683-37-9 | 50MG | $99.36 | 2025-07-31 | Buy |
| TRC | P839730 | 3-(Prop-2-ynyloxy)propanoicAcid | 55683-37-9 | 10mg | $45 | 2021-12-16 | Buy |
| BroadPharm | BP-21981 | Propargyl-PEG1-acid 98% | 55683-37-9 | 100mg | $120 | 2021-12-16 | Buy |
| AK Scientific | 6811BA | 3-(Prop-2-yn-1-yloxy)propanoicacid | 55683-37-9 | 100mg | $143 | 2021-12-16 | Buy |
| Activate Scientific | AS116781 | 3-(Prop-2-yn-1-yloxy)propanoicacid 97+% | 55683-37-9 | 250mg | $210 | 2021-12-16 | Buy |
3-(2-Propynyloxy)propanoic acid Chemical Properties,Uses,Production
Description
Propargyl-PEG1-acid is a crosslinker with a propargyl group and a carboxylic acid group. The carboxylic acid reacts with primary amine under the activation of HATU or EDC. The propargyl group can participate in copper catalyzed azide-alkyne Click Chemistry reactions.
Uses
This is a crosslinker with an alkyne group on one end and a carboxyl group on the other end. The alkyne can be used to attach to an azide using copper-catalyzed click chemistry. The compound contains a single PEG unit to help improve solubility.
reaction suitability
reagent type: linker
Synthesis
488150-84-1
55683-37-9
General procedure for the synthesis of propargyl-monoethylene glycol-carboxylic acid from tert-butyl 3-(prop-2-yn-1-yloxy)propionate: trifluoroacetic acid (8.065 mL, 108.6 mmol) was added to a solution of tert-butyl 3-(prop-2-yn-1-yloxy)propionate (2.0 g, 10.86 mmol) in dichloromethane (50 mL). The reaction mixture was stirred overnight at room temperature and subsequently concentrated under vacuum, co-evaporated with toluene and purified by fast chromatography on 80 g silica gel (using a dichloromethane/methanol gradient elution) to afford 1.1 g of propargyl-monoethyleneglycol-carboxylic acid as an oil (80% yield).1H NMR (400 MHz, DMSO-d6, δ, ppm): 2.46 (t J = 6.4 Hz, 2H); 3.43 (t, J = 2.4 Hz, 1H); 3.63 (t, J = 6.4 Hz, 2H); 4.11 (d, J = 2.4 Hz, 2H); 12.20 (broad peak, 1H).
IC 50
PEGs
References
[1] Patent: WO2017/76998, 2017, A1. Location in patent: Page/Page column 222-223
[2] Israel Journal of Chemistry, 2001, vol. 41, # 4, p. 283 - 295
3-(2-Propynyloxy)propanoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569266 +86-17392581500 | 1015@dideu.com | China | 3986 | 58 |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-0519-85551759 +8613506123987 | marketing1@neostarunited.com | China | 8830 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32470 | 58 |
| Wuhan Borenpharm Co., Ltd | 027-65563561 18717150066 | 3207347307@qq.com | CHINA | 1238 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30229 | 58 |
| XIAMEN SINOPEG BIOTECH CO., LTD. | +86-0592-7761068 +8617350879715 | changaiwei@sinopeg.com | China | 1125 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39042 | 58 |
| Jilin Chinese Academy of Sciences-yanshen Technology | +undefined18143011203 | info@chemextension.com | China | 42056 | 58 |
| Xian confluore Biological Technology Co., Ltd. | +86-15680926068 | 1924344760@confluore.cn | China | 2997 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 |
View Lastest Price from 3-(2-Propynyloxy)propanoic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-02-05 | Propargyl-PEG1-PA
55683-37-9
|
US $0.00-0.00 / g | 1g | 98% | 1g/bottle, 10g/bottle, 100g/bottle | XIAMEN SINOPEG BIOTECH CO., LTD. | |
 |
2026-01-05 | Propargyl-PEG1-acid
55683-37-9
|
US $0.00 / mg | 10g | TargetMol Chemicals Inc. | |||
 |
2025-06-07 | Propargyl-PEG1-acid
55683-37-9
|
US $0.00 / g | 5g | >98.00% | 5g | Xian confluore Biological Technology Co., Ltd. |
-
- Propargyl-PEG1-PA
55683-37-9
- US $0.00-0.00 / g
- 98%
- XIAMEN SINOPEG BIOTECH CO., LTD.
-
- Propargyl-PEG1-acid
55683-37-9
- US $0.00 / mg
- TargetMol Chemicals Inc.
-
- Propargyl-PEG1-acid
55683-37-9
- US $0.00 / g
- >98.00%
- Xian confluore Biological Technology Co., Ltd.
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