3-(2-Propynyloxy)propanoic acid
- CAS No.
- 55683-37-9
- Chemical Name:
- 3-(2-Propynyloxy)propanoic acid
- Synonyms
- 3-(Prop-2-yn-1-yloxy)propanoic acid;Propargyl-PEG1-Acid;Alkyne-PEG1-COOH;Propargyl-PEG1-PA;Propargyl-PEG1-acid >=95%;3-prop-2-ynoxypropanoicaci;3-prop-2-ynoxypropanoic acid;Propargyl-PEG1-acid;3-(2-Propynyloxy)propanoic acid;3-(prop-2-ynyloxy)propanoic acid
- CBNumber:
- CB52175752
- Molecular Formula:
- C6H8O3
- Molecular Weight:
- 128.13
- MDL Number:
- MFCD10689189
- MOL File:
- 55683-37-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 265.8±20.0 °C(Predicted) |
|---|---|
| Density | 1.140±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| pka | 4.19±0.10(Predicted) |
| form | Liquid |
| color | Colorless to light yellow |
| InChI | InChI=1S/C6H8O3/c1-2-4-9-5-3-6(7)8/h1H,3-5H2,(H,7,8) |
| InChIKey | GMFDYXLFHSFUHE-UHFFFAOYSA-N |
| SMILES | C(O)(=O)CCOCC#C |
| UNSPSC Code | 12352106 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| WGK Germany | WGK 3 |
| Storage Class | 10 - Combustible liquids |
3-(2-Propynyloxy)propanoic acid price More Price(56)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 901567 | Propargyl-PEG1-acid ≥95% | 55683-37-9 | 50MG | $115 | 2026-04-30 | Buy |
| ChemScene | CS-0108409 | Propargyl-PEG1-acid ≥97% | 55683-37-9 | 250mg | $22 | 2026-06-04 | Buy |
| ChemScene | CS-0108409 | Propargyl-PEG1-acid ≥97% | 55683-37-9 | 500mg | $39 | 2026-06-04 | Buy |
| ChemScene | CS-0108409 | Propargyl-PEG1-acid ≥97% | 55683-37-9 | 1g | $77 | 2026-06-04 | Buy |
| ChemScene | CS-0108409 | Propargyl-PEG1-acid ≥97% | 55683-37-9 | 5g | $279 | 2026-06-04 | Buy |
3-(2-Propynyloxy)propanoic acid Chemical Properties, Uses, Production
Description
Propargyl-PEG1-acid is a crosslinker with a propargyl group and a carboxylic acid group. The carboxylic acid reacts with primary amine under the activation of HATU or EDC. The propargyl group can participate in copper catalyzed azide-alkyne Click Chemistry reactions.
Uses
This is a crosslinker with an alkyne group on one end and a carboxyl group on the other end. The alkyne can be used to attach to an azide using copper-catalyzed click chemistry. The compound contains a single PEG unit to help improve solubility.
reaction suitability
reagent type: linker
Synthesis
488150-84-1
55683-37-9
General procedure for the synthesis of propargyl-monoethylene glycol-carboxylic acid from tert-butyl 3-(prop-2-yn-1-yloxy)propionate: trifluoroacetic acid (8.065 mL, 108.6 mmol) was added to a solution of tert-butyl 3-(prop-2-yn-1-yloxy)propionate (2.0 g, 10.86 mmol) in dichloromethane (50 mL). The reaction mixture was stirred overnight at room temperature and subsequently concentrated under vacuum, co-evaporated with toluene and purified by fast chromatography on 80 g silica gel (using a dichloromethane/methanol gradient elution) to afford 1.1 g of propargyl-monoethyleneglycol-carboxylic acid as an oil (80% yield).1H NMR (400 MHz, DMSO-d6, δ, ppm): 2.46 (t J = 6.4 Hz, 2H); 3.43 (t, J = 2.4 Hz, 1H); 3.63 (t, J = 6.4 Hz, 2H); 4.11 (d, J = 2.4 Hz, 2H); 12.20 (broad peak, 1H).
IC 50
PEGs
References
[1] Patent: WO2017/76998, 2017, A1. Location in patent: Page/Page column 222-223
[2] Israel Journal of Chemistry, 2001, vol. 41, # 4, p. 283 - 295
3-(2-Propynyloxy)propanoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Hangzhou J&H Chemical Co., Ltd. | 0571-87396432 | sales@jhechem.com | China | 14905 | 59 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66028182 17714375163 | yftan@aikonchem.com | China | 16674 | 50 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
| Bellen Chemistry Co., Ltd. | 010-60400365-8001 15910885229 | service@bellenchem.com | China | 4514 | 60 |
| Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd | 0431-80534353 19917294565 | et@chemextension.com | China | 3904 | 55 |
| Borenpharm Co., Ltd | 027-65563561 | sales@borenpharm.com | China | 1245 | 55 |
| Jinan elephant international trading co., LTD | 13006575422@163.com | China | 6347 | 58 | |
| Amatek Scientific Co. Ltd. | 0512-56316828 400-867-5858;400-867-5858 | info@amateksci.com | China | 28760 | 58 |
| Aikon International Limited | 025-66113011 19370895928 | qzhang@aikonchem.com | China | 15390 | 58 |
View Latest Price from 3-(2-Propynyloxy)propanoic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-24 | Propargyl-PEG1-PA
55683-37-9
|
1g | 98% | 1g/bottle, 10g/bottle, 100g/bottle | XIAMEN SINOPEG BIOTECH CO., LTD. | ||
 |
2026-04-21 | Propargyl-PEG1-acid
55683-37-9
|
10g | TargetMol Chemicals Inc. | ||||
 |
2025-06-07 | Propargyl-PEG1-acid
55683-37-9
|
5g | >98.00% | 5g | Xian confluore Biological Technology Co., Ltd. |
-
- Propargyl-PEG1-PA
55683-37-9
- 98%
- XIAMEN SINOPEG BIOTECH CO., LTD.
-
- Propargyl-PEG1-acid
55683-37-9
- $0.00
- TargetMol Chemicals Inc.
-
- Propargyl-PEG1-acid
55683-37-9
- $0.00
- >98.00%
- Xian confluore Biological Technology Co., Ltd.
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