Propynol ethoxylate
- CAS No.
- 3973-18-0
- Chemical Name:
- Propynol ethoxylate
- Synonyms
- PME;2-(prop-2-yn-1-yloxy)ethan-1-ol;COB;ethoxyL;2-(prop-2-ynyloxy)ethanol;Ethanol, 2-(2-propynyloxy)-;2-(Prop-2-yn-1-yloxy)ethanol;propargyl alcohol ethoxylate;CSTB;3-(2-Hydroxyethoxy)-1-propyne
- CBNumber:
- CB3200872
- Molecular Formula:
- C5H8O2
- Molecular Weight:
- 100.12
- MDL Number:
- MFCD00099294
- MOL File:
- 3973-18-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 80-90 °C(Press: 12-14 Torr) |
|---|---|
| Density | 1.0261 |
| refractive index | 1.4502 |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | Chloroform (Sparingly), Ethyl Acetate (Slightly) |
| form | Oil |
| pka | 14.22±0.10(Predicted) |
| color | Colourless to Pale Yellow |
| Stability | Light Sensitive |
| InChI | InChI=1S/C5H8O2/c1-2-4-7-5-3-6/h1,6H,3-5H2 |
| InChIKey | GHGCQQRMJCSIBQ-UHFFFAOYSA-N |
| SMILES | C(O)COCC#C |
| CAS DataBase Reference | 3973-18-0(CAS DataBase Reference) |
| FDA UNII | 2EQ7D0F9DR |
| EPA Substance Registry System | Ethanol, 2-(2-propynyloxy)- (3973-18-0) |
| UNSPSC Code | 12352202 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P280-P302+P352-P362+P364 |
| Hazard Codes | Xi |
| Risk Statements | 36 |
| Safety Statements | 26 |
| WGK Germany | WGK 1 |
| TSCA | TSCA listed |
| HS Code | 2909498090 |
| Storage Class | 11 - Combustible Solids |
Propynol ethoxylate price More Price(67)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | C4249 | Cystatin B human recombinant, expressed in E. coli | 3973-18-0 | 50μg | $736 | 2026-04-30 | Buy |
| Sigma-Aldrich | SAB2501912 | Anti-CSTB (C-terminal) antibody produced in goat affinity isolated antibody, buffered aqueous solution | 3973-18-0 | 100μG | $545 | 2023-01-07 | Buy |
| Sigma-Aldrich | SAB1304939 | ANTI-CYTB (CENTER) antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution | 3973-18-0 | 400μL | $427 | 2022-05-15 | Buy |
| Usbiological | 569297 | MT-CYB Purifiedbyimmunoaffinitychromatography. | 50ug | $403 | 2026-06-03 | Buy | |
| Usbiological | 569297 | MT-CYB Purifiedbyimmunoaffinitychromatography. | 100ug | $531 | 2026-06-03 | Buy |
Propynol ethoxylate Chemical Properties,Uses,Production
Description
Propargyl-PEG2-alcohol has propargyl and alcohol end groups. The propargyl can participate in copper-catalyzed Click Chemistry reactions with azides.
Chemical Properties
Propynol ethoxylate(PME) is a clear colourless to pale yellow oil.
Uses
Propynol Ethoxylate is an intermediate and it is shown to be used in the design and synthesis of a tag-free chemical probe for photoafiinity labeling.
Application
Propynol ethoxylate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propynol Ethoxylate is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
General Description
Propynol ethoxylate, known as 2-propyn-1-ol, is a colourless flammable liquid with a pleasant odour. This volatile organic compound (VOC) occurs naturally in plants and animals and can also be synthesised in a laboratory environment. Propargyl alcohol polyoxyethylene ether has a wide range of applications and plays an important role in scientific research and industrial processes. It is used as a fuel, solvent and reagent in chemical reactions, as well as an important ingredient in the manufacture of many pharmaceuticals and industrial products. In scientific research, it is used as a reagent in organic synthesis, as a solvent in analytical chemistry and as a fuel in combustion studies.
Synthesis
107-21-1
106-96-7
3973-18-0
4.2.2. Synthesis of 2-(prop-2-ynyloxy)ethanol (2). Under argon protection, propargyl bromide (2.5 mL, 80% toluene solution, 22.5 mmol) was mixed with ethylene glycol (2.5 mL) and cooled to 0 °C in an ice bath. Powdered NaOH (1.08 g, 45.0 mmol) was slowly added to the reaction system, followed by warming the reaction mixture to 45 °C and stirring for 3 hours. After completion of the reaction, the precipitate was removed by filtration and washed with dichloromethane (23 mL). The filtrates were combined and extracted with dichloromethane (310 mL). The crude product was purified by silica gel column chromatography (eluent: hexane/ethyl acetate=2:1) and after evaporation of the solvent under reduced pressure, 1.34 g (60% yield) of target compound 2 was obtained as a light yellow oil. Thin layer chromatography Rf value 0.25 (Expanding agent: hexane/ethyl acetate=2:1). IR spectrum (neat, cm1): 1106, 1246, 1729, 2115, 2868, 2935, 3287, 3400. 1H NMR (CDCl, 250 MHz): δ 2.42 (1H, t, J=2.2 Hz), 2.99 (1H, s), 3.55 (2H, t, J=4.4 Hz), 3.66 (2H, t, J=4.4 Hz), 4.12 (2H, d, J=2.2 Hz).13C NMR (CDCl, 62.5 MHz): δ 58.1, 61.2, 71.0, 74.6, 79.3.High-resolution mass spectra (ESI): [M+H] Calculated CHO: 101.0603, measured: 101.0602.
References
[1] European Journal of Organic Chemistry, 2017, vol. 2017, # 28, p. 4091 - 4103
[2] Angewandte Chemie - International Edition, 2014, vol. 53, # 15, p. 3854 - 3858
[3] Angew. Chem., 2014, vol. 126, # 15, p. 3934 - 3939,5
[4] Journal of the American Chemical Society, 2012, vol. 134, # 14, p. 6491 - 6497
[5] Tetrahedron, 2014, vol. 70, # 35, p. 5961 - 5965
Propynol ethoxylate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shenzhen singcarry New Materials Technology Co., Ltd. | 185-9808-2244 13008845462 | 644851889@qq.com | China | 30 | 58 |
| Hubei Lingyan Biotechnology Co., Ltd | 13297025796 | 2331003879@qq.com | China | 334 | 58 |
| Shenzhen Jihechang New Material Co. , Ltd. | 13823135556 | 262812597@qq.com | China | 120 | 58 |
| Wuhan Pinestone Fortune International Trading Co., Ltd. | 27-85615902 15827493093 | imp.exp8@fengfan.net | China | 49 | 58 |
| WUHAN JADECHEM NEW MATERIALS CO.. LTD | 18602737196 18602737196 | jhc100104@jadechem.com | China | 61 | 58 |
| Sichuan Juxido New Materials Co., Ltd | 13880299455 | 13880299455@163.com | China | 23 | 58 |
| Wuhan Jueyu Environmental Protection Technology Co., Ltd. | 13072706962 | 7772418@qq.com | China | 22 | 58 |
| Wuhan EnTai Technology Development Co,.Ltd | 86-27-82330560 | 2536851935@qq.com | China | 346 | 69 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Beijing HwrkChemical Technology Co., Ltd | 89508211 18501085097 | sales.bj@hwrkchemical.com | China | 9407 | 55 |
View Lastest Price from Propynol ethoxylate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-11 | Propynol ethoxylate
3973-18-0
|
25KG | 98%min | 30tons/month | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-07-24 | Propargyl-PEG2-OH
3973-18-0
|
1g | 98% | 1g/bottle, 10g/bottle, 100g/bottle | XIAMEN SINOPEG BIOTECH CO., LTD. | ||
 |
2026-07-17 | Propynol ethoxylate
3973-18-0
|
1kg | 98 | 1000kgs | Shaanxi Dideu New Materials Co. Ltd |
-
- Propynol ethoxylate
3973-18-0
- $0.00
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Propargyl-PEG2-OH
3973-18-0
- 98%
- XIAMEN SINOPEG BIOTECH CO., LTD.
-
- Propynol ethoxylate
3973-18-0
- $0.00
- 98
- Shaanxi Dideu New Materials Co. Ltd
