3-Methoxy-5-nitrobenzoic acid
- CAS No.
- 78238-12-7
- Chemical Name:
- 3-Methoxy-5-nitrobenzoic acid
- Synonyms
- 3-Methoxy-5-nitrobenzoicaci;3-Methoxy-5-nitrobenzoic acid;Benzoic acid, 3-methoxy-5-nitro-;3-METHOXY-5-NITROBENZOIC ACID ISO 9001：2015 REACH
- CBNumber:
- CB2492546
- Molecular Formula:
- C8H7NO5
- Molecular Weight:
- 197.14
- MDL Number:
- MFCD01318045
- MOL File:
- 78238-12-7.mol
- MSDS File:
- SDS
| Melting point | 186-189 °C |
|---|---|
| Boiling point | 389.5±27.0 °C(Predicted) |
| Density | 1.430±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| pka | 3.36±0.10(Predicted) |
| Appearance | Light yellow to yellow Solid |
| InChI | InChI=1S/C8H7NO5/c1-14-7-3-5(8(10)11)2-6(4-7)9(12)13/h2-4H,1H3,(H,10,11) |
| InChIKey | QXIIPLXNJAJOMR-UHFFFAOYSA-N |
| SMILES | C(O)(=O)C1=CC([N+]([O-])=O)=CC(OC)=C1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H332-H335 |
| Precautionary statements | P261-P280-P305+P351+P338 |
| HS Code | 2916399090 |
3-Methoxy-5-nitrobenzoic acid price More Price(42)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | FM67871 | 3-Methoxy-5-nitrobenzoic acid | 78238-12-7 | 10g | $150 | 2026-06-04 | Buy |
| Biosynth | FM67871 | 3-Methoxy-5-nitrobenzoic acid | 78238-12-7 | 5g | $150 | 2026-06-04 | Buy |
| Biosynth | FM67871 | 3-Methoxy-5-nitrobenzoic acid | 78238-12-7 | 2g | $150 | 2026-06-04 | Buy |
| Biosynth | FM67871 | 3-Methoxy-5-nitrobenzoic acid | 78238-12-7 | 25g | $261 | 2026-06-04 | Buy |
| Apolloscientific | OR345602 | 5-Methoxy-3-nitrobenzoic acid >98% | 78238-12-7 | 250mg | $21 | 2026-06-04 | Buy |
3-Methoxy-5-nitrobenzoic acid Chemical Properties, Uses, Production
Synthesis
99-34-3
865-34-9
78238-12-7
3,5-Dinitrobenzoic acid (5.0 g, 23.57 mmol) was added to a mixed solution of lithium methanolate (LiOMe, 3.6 g, 94.28 mmol) and hexamethylphosphorotriamine (HMPA, 100.0 mL) at room temperature. The reaction mixture was stirred at room temperature for 17 hours before being warmed to 80 °C to continue the reaction for 17 hours. Upon completion of the reaction, the mixture was cooled to room temperature and poured into a mixture of 6 M sulfuric acid (H2SO4) and ice water. Extraction was carried out with ether (Et2O) and the organic phase was washed sequentially with 1N hydrochloric acid (HCl) and saturated brine and dried over anhydrous sodium sulfate (Na2SO4). The organic phase was concentrated under reduced pressure to give a yellow solid 3-methoxy-5-nitrobenzoic acid (4.0 g, 86% yield). The product was characterized by 1H-NMR (300 MHz, DMSO-d6): δ13.76 (brs, 1H), 8.21 (m, 1H), 7.95 (t, 1H, J=2.7Hz), 7.82 (dd, 1H, J=2.7,1.1Hz), 3.94 (s, 3H).
References
[1] Organic Letters, 2009, vol. 11, # 4, p. 791 - 794
[2] Journal of the American Chemical Society, 2005, vol. 127, # 32, p. 11202 - 11203
[3] Patent: WO2014/196793, 2014, A1. Location in patent: Page/Page column 73; 74
[4] Synthesis (Germany), 2016, vol. 48, # 19, p. 3263 - 3271
[5] Patent: EP2364983, 2011, A2. Location in patent: Page/Page column 65
3-Methoxy-5-nitrobenzoic acid Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Amico Chemicals Co. LTD | 微信 18019252918 18019252918 | 1454668768@qq.com | China | 14933 | 58 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Shanghai Sunway Pharmaceutical Technology Co., Ltd | 13761987713 | hxzheng@sunwaypharm.cn | China | 8663 | 57 |
| Shanghai Topbiochem Technology Co., Ltd | +86-21-60341587 | sales@topbiochem.com | China | 6166 | 58 |
| Shanghai T&W Pharmaceutical Co., Ltd. | +86 21 61551611 | China | 9874 | 58 | |
| Nanjing Norris-Pharm Technology Co., Ltd | 13901585132 | sales@norris-pharm.com | China | 8869 | 55 |
| 9ding chemical ( Shanghai) Limited | 4009209199 | sales@9dingchem.com | China | 18201 | 56 |
| SynAsst Chemical. | 021-60343070 | China | 12731 | 55 | |
| Shanghai Witofly Chemical Co.,Ltd | sales@witofly.com | China | 2853 | 52 |
View Latest Price from 3-Methoxy-5-nitrobenzoic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | 3-METHOXY-5-NITROBENZOIC ACID
78238-12-7
|
$1.00-100.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2020-02-26 | 3-methoxy-5-nitrobenzoic acid
78238-12-7
|
1KG | 99.0% | 100 tons | Shaanxi Dideu Medichem Co. Ltd | ||
 |
2020-01-03 | 3-METHOXY-5-NITROBENZOIC ACID
78238-12-7
|
$1.00 | 1KG | 99% | 10000KGS | Career Henan Chemical Co |
-
- 3-METHOXY-5-NITROBENZOIC ACID
78238-12-7
- $1.00-100.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 3-methoxy-5-nitrobenzoic acid
78238-12-7
- 99.0%
- Shaanxi Dideu Medichem Co. Ltd
-
- 3-METHOXY-5-NITROBENZOIC ACID
78238-12-7
- $1.00
- 99%
- Career Henan Chemical Co
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