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3-[4-(BENZYLOXY)PHENYL]ACRYLIC ACID

CAS No.
6272-45-3
Chemical Name:
3-[4-(BENZYLOXY)PHENYL]ACRYLIC ACID
Synonyms
RARECHEM BK HW 0174;4-BENZYLOXYCINNAMIC ACID;(E)-4-BENZYLOXYCINNAMIC ACID;3-[4-(Benzyloxy)Phenyl]AcrylicAci;3-[4-(BENZYLOXY)PHENYL]ACRYLIC ACID;(E)-3-(4-(Benzyloxy)phenyl)acrylic acid;(E)-3-[4-(BENZYLOXY)PHENYL]-2-PROPENOIC ACID;3-[4-(BENZYLOXY)PHENYL]ACRYLIC ACID USP/EP/BP;(2E)-3-(4-(benzyloxy)phenyl)prop-2-enoic acid;2-Propenoic acid, 3-[4-(phenylmethoxy)phenyl]-
CBNumber:
CB2494580
Molecular Formula:
C16H14O3
Molecular Weight:
254.28
MDL Number:
MFCD00021778
MOL File:
6272-45-3.mol
Last updated:2025-09-09 13:52:16

3-[4-(BENZYLOXY)PHENYL]ACRYLIC ACID Properties

Melting point 206-208°C
Boiling point 448.9±25.0 °C(Predicted)
Density 1.212
pka 4.59±0.10(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS02,GHS07
Signal word  Danger
Hazard statements  H225-H302-H319
Precautionary statements  P305+P351+P338
HazardClass  IRRITANT
HS Code  2916399090

3-[4-(BENZYLOXY)PHENYL]ACRYLIC ACID price More Price(14)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich S107263 3-(4-BENZYLOXY-PHENYL)-ACRYLIC ACID AldrichCPR 6272-45-3 1 unit $30.7 2025-07-31 Buy
Sigma-Aldrich S107263 3-(4-BENZYLOXY-PHENYL)-ACRYLIC ACID AldrichCPR 6272-45-3 100MG $29.8 2024-03-01 Buy
TRC B289153 (E)-3-(4-(Benzyloxy)phenyl)acrylicAcid 6272-45-3 50mg $60 2021-12-16 Buy
AK Scientific W7475 (E)-3-(4-(Benzyloxy)phenyl)acrylicacid 6272-45-3 1g $70 2021-12-16 Buy
AK Scientific W7475 (E)-3-(4-(Benzyloxy)phenyl)acrylicacid 6272-45-3 5g $104 2021-12-16 Buy
Product number Packaging Price Buy
S107263 1 unit $30.7 Buy
S107263 100MG $29.8 Buy
B289153 50mg $60 Buy
W7475 1g $70 Buy
W7475 5g $104 Buy

3-[4-(BENZYLOXY)PHENYL]ACRYLIC ACID Chemical Properties,Uses,Production

Synthesis

4-Hydroxycinnamic acid

7400-08-0

Benzyl bromide

100-39-0

3-[4-(BENZYLOXY)PHENYL]ACRYLIC ACID

6272-45-3

GENERAL STEPS: To 4-hydroxycinnamic acid (7 g, 42.6 mmol) was added anhydrous ethanol (40 mL) and stirred until completely dissolved to form a clarified solution. Subsequently, benzyl bromide (15 g, 10.6 mL, 87.7 mmol) and aqueous sodium hydroxide (8.5 g, 212 mmol, dissolved in 40 mL of distilled water) were added sequentially and stirred for 5 minutes to ensure homogeneous mixing. The reaction mixture was placed in a reflux unit and refluxed continuously for 36 hours. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming the complete conversion of 4-hydroxycinnamic acid, the reaction mixture was cooled in an ice bath. Subsequently, the cooled ethanol reaction mixture was slowly poured into a 1-liter beaker containing crushed ice and carefully acidified with 5N hydrochloric acid to the proper pH to induce precipitation of solid compounds. The precipitate was collected by filtration, washed with plenty of water to remove impurities and finally dried to give the white solid product (E)-3-(4-(benzyloxy)phenyl)acrylic acid (10.3 g, 95% yield).

References

[1] Tetrahedron Letters, 2016, vol. 57, # 30, p. 3371 - 3375

104315-07-3
6272-45-3
Synthesis of 3-[4-(BENZYLOXY)PHENYL]ACRYLIC ACID from ETHYL 3-[4-(BENZYLOXY)PHENYL]ACRYLATE

3-[4-(BENZYLOXY)PHENYL]ACRYLIC ACID Preparation Products And Raw materials

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Hebei Mujin Biotechnology Co.,Ltd
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View Lastest Price from 3-[4-(BENZYLOXY)PHENYL]ACRYLIC ACID manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
3-[4-(BENZYLOXY)PHENYL]ACRYLIC ACID pictures 2025-09-09 3-[4-(BENZYLOXY)PHENYL]ACRYLIC ACID
6272-45-3
US $0.00 / KG 1KG 99% 50000KG/month Hebei Mujin Biotechnology Co.,Ltd
3-[4-(Benzyloxy)Phenyl]Acrylic Acid pictures 2025-06-20 3-[4-(Benzyloxy)Phenyl]Acrylic Acid
6272-45-3
US $3.00-9.00 / KG 0.01KG 99% g-kg-tons, free sample is available ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
3-[4-(BENZYLOXY)PHENYL]ACRYLIC ACID pictures 2023-09-07 3-[4-(BENZYLOXY)PHENYL]ACRYLIC ACID
6272-45-3
US $100.00 / bag 1bag 99 5000 Hebei Fengqiang Trading Co., LTD
3-[4-(BENZYLOXY)PHENYL]ACRYLIC ACID (E)-4-BENZYLOXYCINNAMIC ACID (E)-3-[4-(BENZYLOXY)PHENYL]-2-PROPENOIC ACID RARECHEM BK HW 0174 (2E)-3-(4-(benzyloxy)phenyl)prop-2-enoic acid 3-[4-(Benzyloxy)phenyl]acrylic acid, 3-[4-(Benzyloxy)phenyl]prop-2-enoic acid (E)-3-(4-(Benzyloxy)phenyl)acrylic acid 4-BENZYLOXYCINNAMIC ACID 2-Propenoic acid, 3-[4-(phenylmethoxy)phenyl]- 3-[4-(Benzyloxy)Phenyl]AcrylicAci 3-[4-(BENZYLOXY)PHENYL]ACRYLIC ACID USP/EP/BP 6272-45-3 Aromatic Cinnamic Acids, Esters and Derivatives