KR-32568
- CAS No.
- 852146-73-7
- Chemical Name:
- KR-32568
- Synonyms
- KR 32568,KR32568;KR-32568, 10 mM in DMSO;KR-32568 >=98% (HPLC), solid;N-Carbamimidoyl-5-(5-fluoro-2-methylphenyl)furan-2-carboxamide;2-Furancarboxamide, N-(aminoiminomethyl)-5-(5-fluoro-2-methylphenyl)-
- CBNumber:
- CB2498205
- Molecular Formula:
- C13H12FN3O2
- Molecular Weight:
- 261.25
- MDL Number:
- MFCD08705324
- MOL File:
- 852146-73-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 176 °C |
|---|---|
| Density | 1.38±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: ~10 mg/mL |
| form | solid |
| pka | 7.31±0.46(Predicted) |
| color | white |
| InChI | 1S/C13H12FN3O2/c1-7-2-3-8(14)6-9(7)10-4-5-11(19-10)12(18)17-13(15)16/h2-6H,1H3,(H4,15,16,17,18) |
| InChIKey | DTLDHYBZLVASJQ-UHFFFAOYSA-N |
| SMILES | Cc1ccc(F)cc1-c2ccc(o2)C(=O)NC(N)=N |
| FDA UNII | QJ7D8A9YGY |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P270-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| Storage Class | 10 - Combustible liquids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
KR-32568 price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | K4389 | KR-32568 ≥98% (HPLC), solid | 852146-73-7 | 5mg | $261 | 2026-04-30 | Buy |
| Sigma-Aldrich | K4389 | KR-32568 ≥98% (HPLC), solid | 852146-73-7 | 25mg | $949 | 2026-04-30 | Buy |
| Cayman Chemical | 23968 | KR-32568 ≥98% | 852146-73-7 | 1mg | $76 | 2026-04-30 | Buy |
| Cayman Chemical | 23968 | KR-32568 ≥98% | 852146-73-7 | 5mg | $171 | 2026-04-30 | Buy |
| ChemScene | CS-0068503 | KR-32568 99.80% | 852146-73-7 | 5mg | $48 | 2026-06-04 | Buy |
KR-32568 Chemical Properties, Uses, Production
Uses
KR-32568 is a sodium/hydrogen exchanger-1 (NHE-1) inhibitor with an IC50 of 230 nM. KR-32568 has cardioprotective effects[1][2].
Biological Activity
Sodium/hydrogen exchanger-1 (NHE-1) inhibitor; IC50 = 0.23 μM; inhibited NHE-1-mediated rabbit platelet swelling; in anesthetized rats, reduced infarct size from 67% (control) to 43% ( at 0.1 mg/kg) and 24% ( at 1.0 mg/kg); reduced number of ventricular premature beats from 530 to 266 ( at 0.1 mg/kg) and 115 ( at 1.0 mg/kg); reduced ventricular fibrillation incidence from 17 to 8 (0.1 mg/kg) and 0 (1.0 mg/kg); implications for research and treatment of myocardial ischemic diseases.
in vivo
KR-32568 (0.1-1.0 mg/kg; i.v.; once) exert potent cardioprotective effects in rats, such as reduces infarct size, and significantly reduces the total number of ventricular premature beats[1].
| Animal Model: | Male Sprague-Dawley rats (350-380 g) bearing 30 min ischemia/2.5 h reperfusion heart injury[1] |
| Dosage: | 0.1 mg/kg and 1.0 mg/kg |
| Administration: | i.v.; once |
| Result: | Exerted potent cardioprotective effects in rats. |
References
[1] Hui-Yul Roh, et al. Cardioprotective effects of [5-(2-methyl-5-fluorophenyl)furan-2-ylcarbonyl]guanidine (KR-32568) in an anesthetized rat model of ischemia and reperfusion heart injury. Pharmacology. 2005 Dec;75(1):37-44. DOI:10.1159/000086192
[2] Sunkyung Lee, et al. (5-Arylfuran-2-ylcarbonyl)guanidines as cardioprotectives through the inhibition of Na+/H+ exchanger isoform-1. J Med Chem. 2005 Apr 21;48(8):2882-91. DOI:10.1021/jm0492305
KR-32568 Preparation Products And Raw materials
Raw materials
Preparation Products
KR-32568 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Shanghai Chaolan Chemical Technology Center | QQ：65489617 13301690235 | Sales@ATKchemical.com | China | 9729 | 58 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 400-920-5774 | sales@glpbio.cn | China | 6705 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44871 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 | psaitong@jm-bio.com | China | 27626 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
