2-AMINO-5-(4-METHYLPHENYL)-1 3 4-THIADI&
- CAS No.
- 26907-54-0
- Chemical Name:
- 2-AMINO-5-(4-METHYLPHENYL)-1 3 4-THIADI&
- Synonyms
- 2-AMINO-5-(4-METHYLPHENYL)-1 3 4-THIADI&;1,3,4-Thiadiazol-2-aMine, 5-(4-Methylphenyl)-;2-Amino-5-(4-methylphenyl)-1,3,4-thiadiazole 97%;JRH-02705, 5-p-Tolyl-1,3,4-thiadiazol-2-amine, 97%;5-(4-methylphenyl)-1,3,4-thiadiazol-2-amine(SALTDATA: FREE);2-Amino-5-(p-tolyl)-1,3,4-thiadiazole, 5-(p-Tolyl)-1,3,4-thiadiazol-2-amine;5-(4-Methylphenyl)-1,3,4-thiadiazol-2-amine, 5-(p-Tolyl)-1,3,4-thiadiazol-2-amine;4-(5-Amino-1,3,4-thiadiazol-2-yl)toluene, 5-(4-Methylphenyl)-1,3,4-thiadiazol-2-amine
- CBNumber:
- CB2500357
- Molecular Formula:
- C9H9N3S
- Molecular Weight:
- 191.25
- MDL Number:
- MFCD00469688
- MOL File:
- 26907-54-0.mol
- MSDS File:
- SDS
| Melting point | 218-222 °C |
|---|---|
| Boiling point | 364.9±35.0 °C(Predicted) |
| Density | 1.281±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| form | solid |
| pka | 3.11±0.10(Predicted) |
| Appearance | White to off-white Solid |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Hazard Codes | Xn |
| Risk Statements | 22-36/37/38 |
| Safety Statements | 26 |
| WGK Germany | 3 |
| HS Code | 2934999090 |
2-AMINO-5-(4-METHYLPHENYL)-1 3 4-THIADI& price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 663565 | 2-Amino-5-(4-methylphenyl)-1,3,4-thiadiazole 97% | 26907-54-0 | 5g | $223 | 2022-05-15 | Buy |
| TRC | T733833 | 5-(p-Tolyl)-1,3,4-thiadiazol-2-amine | 26907-54-0 | 50mg | $60 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FA54318 | 2-Amino-5-(4-methylphenyl)-1,3,4-thiadiazole | 26907-54-0 | 1g | $83 | 2021-12-16 | Buy |
| AK Scientific | 5728AH | 5-(4-Methylphenyl)-1,3,4-thiadiazol-2-amine | 26907-54-0 | 1g | $105 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FA54318 | 2-Amino-5-(4-methylphenyl)-1,3,4-thiadiazole | 26907-54-0 | 2g | $150 | 2021-12-16 | Buy |
2-AMINO-5-(4-METHYLPHENYL)-1 3 4-THIADI& Chemical Properties,Uses,Production
Synthesis
79-19-6
99-94-5
26907-54-0
General procedure for the synthesis of 5-p-tolylphenyl-2-amino-1,3,4-thiadiazole from aminothiourea and p-toluic acid: 5.1.1 Synthesis of 5-(4-morpholinophenyl)-1,3,4-thiadiazol-2-amine (59) 4-Morpholino benzoic acid (5.18 g, 25 mmol) and N-amino thiourea (2.28 g, 25 mmol) were dissolved in POCl3 (7 mL) and stirred vigorously at 75°C for 0.5 hr. After the reaction was completed, H2O (30 mL) was added and the reaction mixture was heated to reflux for 4 hours. Subsequently, the reaction solution was adjusted with 50% NaOH solution to pH 8. The mixture was filtered and the resulting filter cake was recrystallized with ethanol to give 3.90 g of yellow crystalline compound 59 in 59% yield. Compounds 60-81 were synthesized in the same way. 5.1.1.4 Synthesis of 5-(p-tolyl)-1,3,4-thiadiazol-2-amine (63) Yield: 98%, Melting point: 194-195 °C (EtOH). eSI-MS m/z: 192.3 [M + H]+; 1H NMR (DMSO-d6) δ 2.34 (s, 3H), 7.27 (d, J = 8.4 Hz, 2H), 7.35 (s, 2H), 7.64 (d, J = 8.4 Hz, 2H).
References
[1] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 21, p. 5766 - 5775
[2] Bioorganic and Medicinal Chemistry, 2008, vol. 16, # 14, p. 6663 - 6668
[3] European Journal of Medicinal Chemistry, 2015, vol. 95, p. 49 - 63
[4] European Journal of Medicinal Chemistry, 2015, vol. 106, p. 75 - 84
[5] Medicinal Chemistry Research, 2012, vol. 21, # 6, p. 816 - 824
2-AMINO-5-(4-METHYLPHENYL)-1 3 4-THIADI& Preparation Products And Raw materials
2-AMINO-5-(4-METHYLPHENYL)-1 3 4-THIADI& Suppliers
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