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Febantel

Febantel structure

CAS No.: 58306-30-2

Chemical Name:: Febantel

Synonyms: Non Bantyre;Pro-benzimidazole;Thiophenol guanidine;rintal;Febantel;Febante1;bayvh5757;Bay h-5757;FEBANTEL EP;Febantel CRS

CBNumber:: CB2502427

Molecular Formula:: C20H22N4O6S

Molecular Weight:: 446.48

MDL Number:: MFCD01738527

MOL File:: 58306-30-2.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-07-14 16:49:18

Product description	Number	Pack Size	Price
Febantel for system suitability European Pharmacopoeia (EP) Reference Standard	Y0000660	10 mg	$181
Febantel European Pharmacopoeia (EP) Reference Standard	Y0000556	120 mg	$175
Febantel VETRANAL?, analytical standard	33981	100mg	$116
Febantel United States Pharmacopeia (USP) Reference Standard	1269356	200mg	$424
Febantel European Pharmacopoeia (EP) Reference Standard	Y0000556	150 mg	$164
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Febantel Properties

Melting point	129-130°C
Boiling point	215°C (rough estimate)
Density	1.2962 (rough estimate)
refractive index	1.6000 (estimate)
storage temp.	Sealed in dry,2-8°C
solubility	Chloroform (Sparingly)
form	Solid
pka	7.60±0.46(Predicted)
color	White to Off-White
Merck	14,3944
Major Application	forensics and toxicology pharmaceutical (small molecule)
InChI	InChI=1S/C20H22N4O6S/c1-28-12-17(25)21-16-11-14(31-13-7-5-4-6-8-13)9-10-15(16)22-18(23-19(26)29-2)24-20(27)30-3/h4-11H,12H2,1-3H3,(H,21,25)(H2,22,23,24,26,27)
InChIKey	HMCCXLBXIJMERM-UHFFFAOYSA-N
SMILES	N(C1C=C(SC2C=CC=CC=2)C=CC=1/N=C(\NC(=O)OC)/NC(=O)OC)C(=O)COC
CAS DataBase Reference	58306-30-2(CAS DataBase Reference)
FDA UNII	S75C401OS1
UNSPSC Code	41116107
NACRES	NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302
Precautionary statements	P301+P312+P330
PPE	dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes	Xn
Risk Statements	22
WGK Germany	3
RTECS	FB3955000
HS Code	2930902000
Storage Class	11 - Combustible Solids
Hazard Classifications	Acute Tox. 4 Oral

Febantel price More Price(54)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	Y0000660	Febantel for system suitability European Pharmacopoeia (EP) Reference Standard	58306-30-2	10 mg	$181	2026-04-30	Buy
Sigma-Aldrich	Y0000556	Febantel European Pharmacopoeia (EP) Reference Standard	58306-30-2	120 mg	$175	2026-04-30	Buy
Sigma-Aldrich	33981	Febantel VETRANAL?, analytical standard	58306-30-2	100mg	$116	2026-04-30	Buy
Sigma-Aldrich	1269356	Febantel United States Pharmacopeia (USP) Reference Standard	58306-30-2	200mg	$424	2026-04-30	Buy
Sigma-Aldrich	Y0000556	Febantel European Pharmacopoeia (EP) Reference Standard	58306-30-2	150 mg	$164	2025-07-31	Buy

Product number	Packaging	Price	Buy
Y0000660	10 mg	$181	Buy
Y0000556	120 mg	$175	Buy
33981	100mg	$116	Buy
1269356	200mg	$424	Buy
Y0000556	150 mg	$164	Buy

Febantel Chemical Properties,Uses,Production

Description

Febantel [N-2-( [2,3-bis-(methoxycarbonyl)-guanidine] 5- phenylthio)-phenyl) -2-methoxyacetamide] is a new anthelmintic that is highly active against various species of nematodes and cestodes in rodents, sheep, cattle, and horses. In 1978, febantel was introduced to South Africa under the trade name of Rintal as a sheep drench, and to New Zealand as a sheep and cattle drench, and the USA and Australia as a paste for horse[1].

Chemical Properties

Febantel is White to Off-White Solid

Originator

Rintal, Bayer,W. Germany,1979

Uses

Used as an anthelmintic.

Definition

ChEBI: Febantel is an aryl sulfide.

Manufacturing Process

2-Amino-5-phenylthiornethoxyacetanilide in methanol solution is heated with N,N'-bis-methoxycarbonyl-isothiourea-S-methyl ether with the addition of a catalytic amount of p-toluenesulfonic acid for three hours with stirring under reflux. The mixture is then filtered hot and after cooling the febantel product crystallizes out. It is filtered off, rinsed with ether and dried under high vacuum to give the final product, melting at 129°C to 130°C.

brand name

Combotel (Bayer AnimalHealth); Negabot Plus Paste (Bayer Animal Health); Oratel (Bayer Animal Health); Rintal (Bayer Animal Health).

Therapeutic Function

Anthelmintic

in vivo

In vivo assays indicated that febantel exhibited potent anthelmintic activity against G. kobayashii with an EC50 value of 0.03 mg/L and 100 % anthelmintic efficacy at 0.1 mg/L after 48 h of exposure. Moreover, in vivo trials also revealed a notable post-treatment effect of febantel, where infected goldfish transferred to drug-free water after short 6-h exposure could still result in full eradication of the worms, indicating febantel might induce persistent perturbations in parasite physiology[1].

in vivo

In vitro assays showed a negative correlation between febantel concentrations and the survival of G. Kobayashi. However, increasing the febantel concentration to 2.0 mg/L did not result in the complete death of all worms. Oral administration of febantel demonstrated limited anthelmintic activity, with only 49 % efficacy at 200 mg/kg body weight daily over five days. Acute toxicity assays revealed that the 48-h LC50 value of febantel was 5.47 mg/L, 182.23 times higher than the 48-h EC50 value, indicating that febantel has a favorable safety profile. However, febantel exposure potentially interfered with hepatic metabolism and oxidative status, as indicated by variations in SOD, GST, and P450 gene expression[1].

References

[1] Thomas, H. “Ovacidal activity of febantel.” New Zealand veterinary journal 27 12 (1979): 273–5.

Febantel Preparation Products And Raw materials

Raw materials

3-Chloroaniline

Preparation Products

Febantel Suppliers

Global( 380)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Chuanghai Biotechnology Co,.LTD	+86-86-13131129325	sales1@chuanghaibio.com	China	5216	58
Shaanxi TNJONE Pharmaceutical Co., Ltd		sarah@tnjone.com	China	1139	58
Xi an Biohorlden Industry Trade Co Ltd	+8618829283179	rock@horlden.com	China	334	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21533	55
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418679 +86-18949832763	info@tnjchem.com	China	2984	55
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29766	58
Xiamen AmoyChem Co., Ltd	+86-86-5926051114	sales@amoychem.com	China	6339	58
CONIER CHEM AND PHARMA LIMITED		sales@conier.com	China	49906	58
SIMAGCHEM CORP	+86-5922680277 +86-13806087780	sale@simagchem.com	China	17339	58
TargetMol Chemicals Inc.	+1-781-999-5354; +1-00000000000	marketing@targetmol.com	United States	32431	58

Supplier	Advantage
Hebei Chuanghai Biotechnology Co,.LTD	58
Shaanxi TNJONE Pharmaceutical Co., Ltd	58
Xi an Biohorlden Industry Trade Co Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
Hefei TNJ Chemical Industry Co.,Ltd.	55
career henan chemical co	58
Xiamen AmoyChem Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
SIMAGCHEM CORP	58
TargetMol Chemicals Inc.	58

View Lastest Price from Febantel manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-08-26	Febantel 58306-30-2		1KG	97.5%-101.0%;EP	500kgs	WUHAN FORTUNA CHEMICAL CO., LTD
2026-08-25	Febantel 58306-30-2		1kg	98%	1000	Xi an Biohorlden Industry Trade Co Ltd
2026-08-20	Febantel USP/EP/BP 58306-30-2	$1.10	1g	99.9%	100 Tons Min	Dideu Industries Group Limited

Febantel
58306-30-2
$0.00
97.5%-101.0%;EP
WUHAN FORTUNA CHEMICAL CO., LTD

Febantel
58306-30-2
98%
Xi an Biohorlden Industry Trade Co Ltd

Febantel USP/EP/BP
58306-30-2
$1.10
99.9%
Dideu Industries Group Limited

Febantel Spectrum

Febantel(58306-30-2)MS Febantel(58306-30-2)¹HNMR

58306-30-2(Febantel)Related Search:

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Acetamide Nifuratel (Trifluoromethoxy)benzene 1,5-Diphenylcarbazide 1,3-Diphenylguanidine

PHENYL VALERATE N,N-Dimethylacetamide Phenylacetic acid

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Febantel powder FEBANTEL PESTANAL 2-Acetamido-5-nitrothiazole VETRANAL DIMETHYL[[2-[(METHOXYACETYL)AMINO]-4-(PHENYLTHIO)PHENYL]CARBONIMIDOYL]BISCARBAMATE(FEBANTEL) Febantel N-{2-[2,3-Bis-(methoxycarbonyl)-guanido]-5-(phenylthio)-phenyl}-2-methoxyacetamide Carbamicacid,[[2-[(methoxyacetyl)amino]-4-(phenylthio)phenyl]carbonimidoyl]bis-,dimethylester n-(2-(2,3-bis-(methoxycarbonyl)-guanidino)-5-(phenylthio)-phenyl)-2-methoxya rintal [N-[2-[(Methoxyacetyl)amino]-4-(phenylthio)phenyl]carbonimidoyl]biscarbamic acid dimethyl ester Bay h-5757 N,N'-[[2-[(2-Methoxyacetyl)amino]-4-(phenylthio)phenyl]imidocarbonyl]bis(carbamic acid methyl) ester FEBANTEL EP febantel pestanal Solution, 100ppm methyl (2-(2-methoxyacetamido)-4-(phenylthio)phenylamino)(methoxycarbonylamino)methylenecarbamate [[2-[(Methoxyacetyl)amino]-4-(phenylthio)phenyl]-carbonimidoyl]biscarbamicaciddimethylester bayvh5757 carbamicacid,((2-((methoxyacetyl)amino)-4-(phenylthio)phenyl)carbonimidoyl)bi (NE)-N-[(methoxycarbonylamino)-[2-[(2-methoxy-1-oxoethyl)amino]-4-(phenylthio)anilino]methylidene]carbamic acid methyl ester Febantel for system suitability CRS Febantel CRS Febantel Standard methyl N-[N-[2-[(2-methoxyacetyl)amino]-4-phenylsulfanyl-phenyl]-N'-methoxycarbonyl-carbamimidoyl]carbamate 　 Carbamic acid, N,N'-[[2-[(2-methoxyacetyl)amino]-4-(phenylthio)phenyl]carbonimidoyl]bis-, C,C'-dimethyl ester Febantel solution in Acetonitrile, 100μg/mL Febantel USP/EP/BP N-(((2-(2-MEthoxyacetamido)-4-(phenylsulfanyl)phenyl)amino)((methoxycarbonyl)imino)methyl)carbamate Febantel (1269356) 5-Dimethoxyphenol Febantel EP/BP Methyl 3-[[2-(2-Methoxyacetylamino)-4-phenylthiophenyl]amino]-3-(methoxycarbonylamino)-2-aza-2-propenoate Febante1 C13407000 Febantel Febantel Impurity Febantel, 10 mM in DMSO Non Bantyre (phenylthioguanidine) Non Bantyre Pro-benzimidazole Thiophenol guanidine 58306-30-2 C20H22N4O6S Pharmaceutical intermediate Intermediates & Fine Chemicals Pharmaceuticals 58306-30-2