NIK SMI1
- CAS No.
- 1660114-31-7
- Chemical Name:
- NIK SMI1
- Synonyms
- NIK SMI1;NIK SMI1, 10 mM in DMSO;NIK inhibitor 4f(NIK SMI1);4-methoxy-6-(3-methylphenyl)pyridine-2-carboxamide;(R)-6-(3-((3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl)ethynyl)phenyl)-4-methoxypicolinamide;NIK SMI1,Nuclear factor-κB,NIK SMI 1,Nuclear factor-kappaB,inhibit,Inhibitor,NF-κB,NIK SMI-1;2-Pyridinecarboxamide, 6-[3-[2-[(3R)-3-hydroxy-1-methyl-2-oxo-3-pyrrolidinyl]ethynyl]phenyl]-4-methoxy-
- CBNumber:
- CB25419793
- Molecular Formula:
- C20H19N3O4
- Molecular Weight:
- 365.38
- MDL Number:
- MFCD31715434
- MOL File:
- 1660114-31-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 626.7±55.0 °C(Predicted) |
|---|---|
| Density | 1.39±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO : 100 mg/mL (273.69 mM) |
| form | Solid |
| pka | 11.14±0.20(Predicted) |
| color | Off-white to pink |
| InChI | 1S/C20H19N3O4/c1-23-9-8-20(26,19(23)25)7-6-13-4-3-5-14(10-13)16-11-15(27-2)12-17(22-16)18(21)24/h3-5,10-12,26H,8-9H2,1-2H3,(H2,21,24)/t20-/m0/s1 |
| InChIKey | LQSHXYHWYGKAMX-FQEVSTJZSA-N |
| SMILES | NC(C1=NC(C2=CC(C#C[C@]3(C(N(CC3)C)=O)O)=CC=C2)=CC(OC)=C1)=O |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
NIK SMI1 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML3129 | NIK SMI1 ≥95% (HPLC) | 1660114-31-7 | 5MG | $277 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML3129 | NIK SMI1 ≥95% (HPLC) | 1660114-31-7 | 25MG | $851 | 2026-04-30 | Buy |
| Cayman Chemical | 37750 | NIK SMI1 ≥98% | 1660114-31-7 | 1mg | $63 | 2026-04-30 | Buy |
| Cayman Chemical | 37750 | NIK SMI1 ≥98% | 1660114-31-7 | 5mg | $248 | 2026-04-30 | Buy |
| Cayman Chemical | 37750 | NIK SMI1 ≥98% | 1660114-31-7 | 10mg | $433 | 2026-04-30 | Buy |
NIK SMI1 Chemical Properties,Uses,Production
Uses
NIK SMI1 is a highly potent and selective NF-κB-inducing kinase (NIK) inhibitor.
Biological Activity
NIK SMI1 is an orally active, ATP site-targeting, potent and selective NF-KB-inducing kinase inhibitor (h/m NIK IC50 = 230/395 pM; hKHS1/hPKD1/hLRRK2 = 49.6/75.2/247.8 nM) th at selectively disrupts noncanonical NF-KB signaling (anti-LTβR-induced p52 nuclear translocation IC50 = 70 nM; TNFα-induced p65 RelA nuclear translocation IC50 >2 μM). SMI1 inhibits BAFF receptor- and CD40-mediated singling in cultures (human and murine B-cells) and shows in vivo efficacy in the NZB/W F1 murine experimental lupus model (6-400 mg/kg/day, b.i.d. p.o.).
in vivo
C57BL/6 mice are treated twice daily for 7 days with orally administered NIK SMI1 or with three injections of recombinant BAFF receptor fusion protein (Br3- mIgG2a) over the course of the 7-day experiment as a positive control. The nonlinearity of exposure relative to dose between 100 and 200 mg/kg is a result of saturation of clearance mechanisms. The pharmacology of NIK SMI1 is examined in SD rat, CD-1 mouse, beagle, and cynomologous monkey with 20, 32, 18, and 7.8 mL/kg per min, respectively. Volume of distribution (Vd, L/kg) is 1.35, 1.58, 0.778, and 1.39, respectively[1].
NIK SMI1 Preparation Products And Raw materials
Raw materials
Preparation Products
NIK SMI1 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4861 | 55 | |
| Shanghaizehan biopharma technology co., Ltd. | 021-61350663 13052117465 | sales@zehanbiopharma.com | China | 989 | 55 |
| Shanghai Shanyuan pharmaceutical technology co., LTD | 021-31761238 13167072949 | 3146446224@qq.com | China | 1420 | 55 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
| Shanghai Rechem science Co., Ltd. | 021-31433387 15618786686 | sales@rechemscience.com | China | 2971 | 58 |
| Shanghai Chaolan Chemical Technology Center | QQ：65489617 13301690235 | Sales@ATKchemical.com | China | 9699 | 58 |
| Shanghai SuperLan Chemcial Technique Centre | 0-2022843681 15618226720 | chaolaichem@foxmail.com | China | 9996 | 58 |
| Beijing Solarbio Science & Tecnology Co., Ltd. | 17801761073 18101056239 | 3193328036@qq.com | China | 28150 | 68 |
| Chuzhou KeMail Chemical Technology Co., Ltd | 0550-5196001 15000891977 | wj520wjxby@126.com | China | 1940 | 55 |
