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JAK3 covalent inhibitor-1

JAK3 covalent inhibitor-1 structure

CAS No.: 2300106-50-5

Chemical Name:: JAK3 covalent inhibitor-1

Synonyms: JAK3 COVALENT INHIBITOR-1;JAK3 covalent inhibitor1,JAK3 covalent inhibitor 1,JAK-3 covalent inhibitor-1;Benzenesulfonamide, N-[(1R,3S)-3-(cyanoamino)-2,3-dihydro-5-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-inden-1-yl]-3-fluoro-

CBNumber:: CB25540374

Molecular Formula:: C22H17FN6O2S

Molecular Weight:: 448.47

MDL Number:: MFCD32067927

MOL File:: 2300106-50-5.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-04-24 14:58:25

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JAK3 covalent inhibitor-1 Properties

Density	1.55±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	Soluble in DMSO
pka	9.70±0.40(Predicted)

JAK3 covalent inhibitor-1 Chemical Properties, Uses, Production

Description

JAK3 covalent inhibitor-1 is a potent and selective janus kinase 3 (JAK3) covalent inhibitor with an IC50 of 11 nM and shows 246-fold selectivity vs other JAKs[1]. JAK3|11 nM (IC50)

Uses

JAK3 covalent inhibitor-1 is a potent and selective janus kinase 3 (JAK3) covalent inhibitor with an IC50 of 11 nM and shows 246-fold selectivity vs other JAKs[1].

IC 50

JAK3: 11 nM (IC₅₀)

References

[1]. Casimiro-Garcia A, et al. Identification of Cyanamide-Based Janus Kinase 3 (JAK3) Covalent Inhibitors. J Med Chem. 2018 Dec 13;61(23):10665-10699.

JAK3 covalent inhibitor-1 Preparation Products And Raw materials

Raw materials

Preparation Products

JAK3 covalent inhibitor-1 Suppliers

Global Suppliers ( 6)

Supplier	Tel	Email	Country	ProdList	Advantage
BOC Sciences	1-631-485-4226; 16314854226	info@bocsci.com	United States	9920	65
TargetMol Chemicals Inc.	+1-781-999-5354; +1-00000000000	marketing@targetmol.com	United States	32431	58
Chengdu Peter-like Biotechnology Co., Ltd.	18108052721	2850505130@qq.com	China	5037	58
TargetMol Chemicals Inc.	4008200310 15002144251	marketing@tsbiochem.com	China	24951	58
Nantong Hanfang Biotechnology Co. , Ltd.	hanfangpharma@126.com 18017580634	hanfangpharma@126.com	China	25800	58

Supplier	Advantage
BOC Sciences	65
TargetMol Chemicals Inc.	58
Chengdu Peter-like Biotechnology Co., Ltd.	58
TargetMol Chemicals Inc.	58
Nantong Hanfang Biotechnology Co. , Ltd.	58

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JAK1 Protein, HUMAN (P. PASTORIS, HIS)

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JAK3 COVALENT INHIBITOR-1 JAK3 covalent inhibitor1,JAK3 covalent inhibitor 1,JAK-3 covalent inhibitor-1 Benzenesulfonamide, N-[(1R,3S)-3-(cyanoamino)-2,3-dihydro-5-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-inden-1-yl]-3-fluoro- 2300106-50-5