Benzenepropanoic acid, 2-[3-[(2,4-diamino-6-ethyl-5-pyrimidinyl)oxy]propoxy]-
![Benzenepropanoic acid, 2-[3-[(2,4-diamino-6-ethyl-5-pyrimidinyl)oxy]propoxy]- Structure](CAS/20200515/GIF/1142407-81-5.gif)
- CAS No.
- 1142407-81-5
- Chemical Name:
- Benzenepropanoic acid, 2-[3-[(2,4-diamino-6-ethyl-5-pyrimidinyl)oxy]propoxy]-
- Synonyms
- DHFR-IN-5;Benzenepropanoic acid, 2-[3-[(2,4-diamino-6-ethyl-5-pyrimidinyl)oxy]propoxy]-
- CBNumber:
- CB25946211
- Molecular Formula:
- C18 H24 N4 O4
- Molecular Weight:
- 360.41
- MDL Number:
- MOL File:
- 1142407-81-5.mol
- MSDS File:
- SDS
Benzenepropanoic acid, 2-[3-[(2,4-diamino-6-ethyl-5-pyrimidinyl)oxy]propoxy]- price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0646584 | DHFR-IN-5 99.27% | 1142407-81-5 | 5mg | $487 | 2026-06-04 | Buy |
| ChemScene | CS-0646584 | DHFR-IN-5 99.27% | 1142407-81-5 | 10mg | $802 | 2026-06-04 | Buy |
| ChemScene | CS-0646584 | DHFR-IN-5 99.27% | 1142407-81-5 | 25mg | $1679 | 2026-06-04 | Buy |
| aablocks | AA02E7OG | 3-(2-(3-((2,4-Diamino-6-ethylpyrimidin-5-yl)oxy)propoxy)phenyl)propanoic acid >98% | 1142407-81-5 | 5mg | $535 | 2026-06-03 | Buy |
| aablocks | AA02E7OG | 3-(2-(3-((2,4-Diamino-6-ethylpyrimidin-5-yl)oxy)propoxy)phenyl)propanoic acid >98% | 1142407-81-5 | 10mg | $858 | 2026-06-03 | Buy |
Benzenepropanoic acid, 2-[3-[(2,4-diamino-6-ethyl-5-pyrimidinyl)oxy]propoxy]- Chemical Properties, Uses, Production
Uses
DHFR-IN-5 is a potent and orally active dihydrofolate reductase (DHFR) inhibitor with a Ki value of 0.54 nM for quadruple mutant Plasmodium falciparum DHFR. DHFR-IN-5 shows anti-malaria activity[1].
in vivo
DHFR-IN-5 (compound p218) (30 mg/kg; p.o.) shows anti-malaria activity with good oral bioavailability (46.3%), a reasonable half-life (7.3 h) in rats[1].
| Animal Model: | Rats[1] |
| Dosage: | 30 mg/kg |
| Administration: | P.o. |
| Result: | Showed good oral bioavailability (46.3%), a reasonable half-life (7.3 h), and minimal distribution into the brain. |
References
[1] Yuthavong Y, et al. Malarial dihydrofolate reductase as a paradigm for drug development against a resistance-compromised target. Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):16823-8. DOI:10.1073/pnas.1204556109
Benzenepropanoic acid, 2-[3-[(2,4-diamino-6-ethyl-5-pyrimidinyl)oxy]propoxy]- Preparation Products And Raw materials
Raw materials
Preparation Products
Benzenepropanoic acid, 2-[3-[(2,4-diamino-6-ethyl-5-pyrimidinyl)oxy]propoxy]- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Dexuan Pharmaceutical Technology Co., Ltd | dexuanyiyao@126.com | dexuanyiyao@126.com | China | 9470 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| TargetMol Chemicals Inc. | 13564774135 | marketing@targetmol.com | United States | 19950 | 58 |
| Supplier | Advantage |
|---|---|
| Shanghai Dexuan Pharmaceutical Technology Co., Ltd | 58 |
| TargetMol Chemicals Inc. | 58 |
| TargetMol Chemicals Inc. | 58 |
