Benzenepropanoic acid, 2-[3-[(2,4-diamino-6-ethyl-5-pyrimidinyl)oxy]propoxy]- manufacturers
- DHFR-IN-5
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- $1520.00
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2026-07-15
- CAS:1142407-81-5
- Purity:
- Supply Ability: 10g
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| | Benzenepropanoic acid, 2-[3-[(2,4-diamino-6-ethyl-5-pyrimidinyl)oxy]propoxy]- Basic information |
| | Benzenepropanoic acid, 2-[3-[(2,4-diamino-6-ethyl-5-pyrimidinyl)oxy]propoxy]- Chemical Properties |
| form | Solid | | color | Off-white to gray |
| | Benzenepropanoic acid, 2-[3-[(2,4-diamino-6-ethyl-5-pyrimidinyl)oxy]propoxy]- Usage And Synthesis |
| Uses | DHFR-IN-5 is a potent and orally active dihydrofolate reductase (DHFR) inhibitor with a Ki value of 0.54 nM for quadruple mutant Plasmodium falciparum DHFR. DHFR-IN-5 shows anti-malaria activity[1]. | | in vivo | DHFR-IN-5 (compound p218) (30 mg/kg; p.o.) shows anti-malaria activity with good oral bioavailability (46.3%), a reasonable half-life (7.3 h) in rats[1]. | Animal Model: | Rats[1] | | Dosage: | 30 mg/kg | | Administration: | P.o. | | Result: | Showed good oral bioavailability (46.3%), a reasonable half-life (7.3 h), and minimal distribution into the brain. |
| | References | [1] Yuthavong Y, et al. Malarial dihydrofolate reductase as a paradigm for drug development against a resistance-compromised target. Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):16823-8. DOI:10.1073/pnas.1204556109 |
| | Benzenepropanoic acid, 2-[3-[(2,4-diamino-6-ethyl-5-pyrimidinyl)oxy]propoxy]- Preparation Products And Raw materials |
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