2,6-Dimethyl-4-nitrophenol
- CAS No.
- 2423-71-4
- Chemical Name:
- 2,6-Dimethyl-4-nitrophenol
- Synonyms
- NSC 2990;4-nitro-6-xylenol;4-NITRO-2,6-XYLENOL;2,6-Xylenol, 4-nitro-;4-Nitro-2,6-dimethylphenol;2,6-Dimethyl-4-nitrophenol;Phenol, 2,6-dimethyl-4-nitro-;2,6-dimethyl-4-nitrophenolate;2,6-Dimethyl-4-nitrophenol>2,6-Dimethyl-4-nitrophenol 98%
- CBNumber:
- CB2694098
- Molecular Formula:
- C8H9NO3
- Molecular Weight:
- 167.16
- MDL Number:
- MFCD00007339
- MOL File:
- 2423-71-4.mol
- MSDS File:
- SDS
| Melting point | 168 °C (dec.)(lit.) |
|---|---|
| Boiling point | 285.73°C (rough estimate) |
| Density | 1.1820 (estimate) |
| refractive index | 1.5774 (estimate) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly, Sonicated) |
| form | Solid |
| pka | pK1:7.190 (25°C) |
| color | Dark Yellow to Very Dark Yellow |
| Water Solubility | Insoluble in water. |
| BRN | 1873275 |
| InChI | 1S/C8H9NO3/c1-5-3-7(9(11)12)4-6(2)8(5)10/h3-4,10H,1-2H3 |
| InChIKey | FNORUNUDZNWQFF-UHFFFAOYSA-N |
| SMILES | Cc1cc(cc(C)c1O)[N+]([O-])=O |
| CAS DataBase Reference | 2423-71-4(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | A5X46MMK2G |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H335-H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | ZE8225000 | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 29089990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Toxicity | mouse,LDLo,intraperitoneal,500mg/kg (500mg/kg),"Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. Vol. 6, Pg. 64, 1954. | |||||||||
| NFPA 704 |
|
2,6-Dimethyl-4-nitrophenol price More Price(46)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 132713 | 2,6-Dimethyl-4-nitrophenol 98% | 2423-71-4 | 1g | $41 | 2023-06-20 | Buy |
| Sigma-Aldrich | 132713 | 2,6-Dimethyl-4-nitrophenol 98% | 2423-71-4 | 10g | $111 | 2023-06-20 | Buy |
| TCI Chemical | D2531 | 2,6-Dimethyl-4-nitrophenol >98.0%(GC) | 2423-71-4 | 5g | $80 | 2026-04-30 | Buy |
| TCI Chemical | D2531 | 2,6-Dimethyl-4-nitrophenol >98.0%(GC) | 2423-71-4 | 25g | $319 | 2026-04-30 | Buy |
| TRC | TRC-D460155-50MG | 2,6-Dimethyl-4-nitrophenol | 2423-71-4 | 50mg | $76 | 2026-06-03 | Buy |
2,6-Dimethyl-4-nitrophenol Chemical Properties,Uses,Production
Chemical Properties
orange crystalline powder
Uses
2,6-Dimethyl-4-nitrophenol was used to study the disposition requirement for binding of p-nitrophenol and sodium p-nitrophenolate like substrates with cyclohexaamylaose. It was used as internal standard in determination of 4-nitrophenol and 3-methyl-4-nitrophenol in human urine by liquid chromatography combined with tandem mass spectrometry .
Uses
2,6-Dimethyl-4-nitrophenol is a useful compound for the production and characterization of bio-oil from hardwood and softwood lignin.
Synthesis Reference(s)
Synthetic Communications, 16, p. 63, 1986 DOI: 10.1080/00397918608057689
Synthesis
576-26-1
2423-71-4
4906-22-3
General method: A solid mixture of 2,6-dimethylphenol (1-3 eq.) and Bi(NO3)3-3H2O (1 eq.) or Fe(NO3)3-9H2O (1 eq.) was mixed with acetone (10 mL/mmol). The reaction mixture was stirred in air at room temperature or under reflux conditions for 2-24 hours (see Tables 1 and 2). Upon completion of the reaction, the insoluble material was removed by filtration through a diatomaceous earth pad and the residue was washed with acetone (~5 mL/mmol). The filtrate was treated with NaHCO3 (0.1 g/mmol) until CO2 release ceased. The insoluble material was removed by filtration again, followed by concentration under reduced pressure in a water bath at 25-35°C to remove the solvent. The nitration products were separated or purified by silica gel column chromatography to give pure phenolic compounds. All products were characterized by 1H NMR, 13C NMR and IR and identified by comparison with spectral data and melting points reported in the literature.
References
[1] Synthetic Communications, 2015, vol. 45, # 1, p. 143 - 150
2,6-Dimethyl-4-nitrophenol Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Changzhou Huanling Chemical Co., Ltd. | 89803005 18206112582 | info@huanlingchem.com | China | 983 | 68 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Shanghai Longsheng chemical Co.,Ltd. | 58099637 13585536065 | sales@shlschem.com | China | 9880 | 59 |
| Syntechem Co.,Ltd | info@syntechem.com | China | 12973 | 57 | |
| Shanghai Topbiochem Technology Co., Ltd | 021-58170097 | info@topbiochem.com | China | 9513 | 58 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66113011 13913916777 | cfzhang@aikonchem.com | China | 19902 | 55 |
2423-71-4(2,6-Dimethyl-4-nitrophenol)Related Search:
1of4
