1-Methyl-3,5-dinitro-1H-pyridin-2-one
- CAS No.
- 14150-94-8
- Chemical Name:
- 1-Methyl-3,5-dinitro-1H-pyridin-2-one
- Synonyms
- 1-Methyl-3,5-dinitropyridin-2(1H)-one;1-Methyl-3,5-dinitro-2-pyridone;Atogepant Impurity 14;1-Methyl-3,5-dinitro-1H-p...;1-Methyl-3,5-dinitropyridine-2;3,5-Dinitro-1-methyl-2-pyridone;1-Methyl-3,5-dinitro-2-pyridine;1-Methyl-3,5-dinitro-2-pyridinone;1-METHYL-3,5-DINITROPYRIDIN-2-ONE;1-methyl-3,5-dinitro-2(1H)-Pyridinone
- CBNumber:
- CB9352014
- Molecular Formula:
- C6H5N3O5
- Molecular Weight:
- 199.12
- MDL Number:
- MFCD00456280
- MOL File:
- 14150-94-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 174-178℃ |
|---|---|
| Boiling point | 289.5±40.0 °C(Predicted) |
| Density | 1.60 |
| storage temp. | Store at 0-8℃ |
| pka | -8.36±0.62(Predicted) |
| form | powder to crystal |
| color | Light orange to Yellow to Green |
| λmax | 308nm(H2O)(lit.) |
| InChI | InChI=1S/C6H5N3O5/c1-7-3-4(8(11)12)2-5(6(7)10)9(13)14/h2-3H,1H3 |
| InChIKey | QARVELJVEBLWGK-UHFFFAOYSA-N |
| SMILES | C1(=O)N(C)C=C([N+]([O-])=O)C=C1[N+]([O-])=O |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P301+P312+P330 | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Faceshields, Gloves | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 2933399990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral | |||||||||
| NFPA 704 |
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1-Methyl-3,5-dinitro-1H-pyridin-2-one price More Price(56)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 680885 | 1-Methyl-3,5-dinitropyridin-2(1H)-one 97% | 14150-94-8 | 1g | $83.2 | 2023-06-20 | Buy |
| TCI Chemical | M2820 | 1-Methyl-3,5-dinitro-2-pyridone >98.0%(GC) | 14150-94-8 | 1g | $62 | 2026-04-30 | Buy |
| Usbiological | 284067 | 1-Methyl-3,5-dinitro-1H-pyridin-2-one Asreported | 14150-94-8 | 500mg | $333 | 2026-06-03 | Buy |
| Usbiological | 284067 | 1-Methyl-3,5-dinitro-1H-pyridin-2-one Asreported | 14150-94-8 | 1g | $506 | 2026-06-03 | Buy |
| Usbiological | 284067 | 1-Methyl-3,5-dinitro-1H-pyridin-2-one Asreported | 14150-94-8 | 2g | $689 | 2026-06-03 | Buy |
1-Methyl-3,5-dinitro-1H-pyridin-2-one Chemical Properties,Uses,Production
Uses
1-Methyl-3,5-dinitro-1H-pyridin-2-one can be used as an organic synthesis intermediate involved in the efficient synthesis of nitrocyclic ether[b]pyridine. It is also a nucleophilic reagent. It reacts with primary amines to produce carbamates in an efficient way without using reducing agents. The electronic defects of the pyridine cation allow this nucleophilic attack.
Synthesis
694-85-9
14150-94-8
General procedure for the synthesis of 1-methyl-3,5-dinitro-1H-pyridin-2-one from 1-methyl-2-pyridone: To a stirred mixture of 1-methyl-2-pyridone (33.47 g, 0.306 mol) and concentrated sulfuric acid (300 mL) was added concentrated nitric acid (120 mL) in batches at 100 °C. The reaction mixture was heated at this temperature overnight and then poured into ice (1400 mL). The precipitate was collected by filtration and washed with water to afford 1-methyl-3,5-dinitro-1H-pyridin-2-one (yield: 18.66 g, 30%).1H NMR (400 MHz, CDCl3): δ 9.05 (d, 1H), 8.90 (d, 1H), 3.80 (s, 3H).
References
[1] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 20, p. 5392 - 5397
[2] Patent: WO2004/69832, 2004, A2. Location in patent: Page 137-138
[3] Patent: US2011/98311, 2011, A1
[4] Patent: US2012/309758, 2012, A1
[5] Patent: US2015/231142, 2015, A1. Location in patent: Paragraph 0698
1-Methyl-3,5-dinitro-1H-pyridin-2-one Preparation Products And Raw materials
Raw materials
Preparation Products
1of2
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jinan Guangchen Pharmaceutical Technology Co., Ltd | 18563726319 | 2845578351@qq.com | China | 7026 | 58 |
| ChemFuture PharmaTech (Jiangsu) Ltd | 5108538618 | suger.wang@chemfuture.com | China | 832 | 65 |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 5996 | 61 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Shanghai Longsheng chemical Co.,Ltd. | 58099637 13585536065 | sales@shlschem.com | China | 9880 | 59 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Tianjin heowns Biochemical Technology Co., Ltd. | 400 638 7771 | sales@heowns.com | China | 14412 | 57 |
| Shanghai Sunway Pharmaceutical Technology Co., Ltd | 13761987713 | hxzheng@sunwaypharm.cn | China | 8663 | 57 |
View Lastest Price from 1-Methyl-3,5-dinitro-1H-pyridin-2-one manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | 1-METHYL-3,5-DINITRO-1H-PYRIDIN-2-ONE
14150-94-8
|
$1.10 | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2024-02-27 | 1-Methyl-3,5-dinitropyridin-2(1H)-one
14150-94-8
|
1kg | 99% | 100 tons | Hpets Biotech Company (Chongqing) Co.,ltd | ||
 |
2022-01-27 | 1-Methyl-3,5-dinitro-1H-pyridin-2-one
14150-94-8
|
1KG | 98.9% | 100 tons | Honest Joy Holdings Limited |
-
- 1-METHYL-3,5-DINITRO-1H-PYRIDIN-2-ONE
14150-94-8
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 1-Methyl-3,5-dinitropyridin-2(1H)-one
14150-94-8
- $0.00
- 99%
- Hpets Biotech Company (Chongqing) Co.,ltd
-
- 1-Methyl-3,5-dinitro-1H-pyridin-2-one
14150-94-8
- $0.00
- 98.9%
- Honest Joy Holdings Limited
