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2-Hydroxy-4-methoxybenzaldehyde

2-Hydroxy-4-methoxybenzaldehyde Structure
2-Hydroxy-4-methoxybenzaldehyde structure
CAS No.
673-22-3
Chemical Name:
2-Hydroxy-4-methoxybenzaldehyde
Synonyms
4-METHOXYSALICYLALDEHYDE;4-Mthoxysalicylaldehyde;Benzaldehyde, 2-hydroxy-4-methoxy-;AKOS 222-39;2-Hydroxy-4-methoxyb;2-Hydroxyanisaldehyde;Entacapone Impurity 65;2-hydroxy-p-anisaldehyd;4-Methoxysalicyaldehyde;4-MethoxySalicyladehyde
CBNumber:
CB2695303
Molecular Formula:
C8H8O3
Molecular Weight:
152.15
MDL Number:
MFCD00003327
MOL File:
673-22-3.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-08-30 11:39:11
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2-Hydroxy-4-methoxybenzaldehyde Properties

Melting point 41-43 °C (lit.)
Boiling point 124 °C / 12mmHg
Density 1.2143 (rough estimate)
refractive index 1.4447 (estimate)
FEMA 4435 | 2-HYDROXY-4-METHOXYBENZALDEHYDE
FLAVIS Number 05.229 | 2-hydroxy-4-methoxybenzaldehyde
Flash point >230 °F
storage temp. Store below +30°C.
solubility DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml
form Crystalline Powder
pka 7.79±0.10(Predicted)
color Creamy white to beige or light brown
Odor at 100.00 %. vanillin like
Odor Type vanilla
Water Solubility Solubility in methanol is almost transparent. Insoluble in water.
Sensitive Air Sensitive
JECFA Number 2277
BRN 1072443
InChI 1S/C8H8O3/c1-11-7-3-2-6(5-9)8(10)4-7/h2-5,10H,1H3
InChIKey WZUODJNEIXSNEU-UHFFFAOYSA-N
SMILES [H]C(=O)c1ccc(OC)cc1O
LogP 1.79
CAS DataBase Reference 673-22-3(CAS DataBase Reference)
Substances Added to Food (formerly EAFUS) 2-HYDROXY-4-METHOXYBENZALDEHYDE
EWG's Food Scores 1
FDA UNII 2N395P88LW
NIST Chemistry Reference Benzaldehyde, 2-hydroxy-4-methoxy-(673-22-3)
EPA Substance Registry System Benzaldehyde, 2-hydroxy-4-methoxy- (673-22-3)
UNSPSC Code 12352114
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36-24/25
WGK Germany  3
RTECS  BZ2810000
F  10
Hazard Note  Irritant
TSCA  TSCA listed
HS Code  29124900
Storage Class 11 - Combustible Solids
REACH Registrations Active
NFPA 704
1
2 0

2-Hydroxy-4-methoxybenzaldehyde price More Price(109)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 160695 2-Hydroxy-4-methoxybenzaldehyde 98% 673-22-3 5g $145 2026-04-30 Buy
Sigma-Aldrich 160695 2-Hydroxy-4-methoxybenzaldehyde 98% 673-22-3 25g $656 2026-04-30 Buy
Sigma-Aldrich 8.41611 2-Hydroxy-4-methoxybenzaldehyde for synthesis 673-22-3 5G $97.2 2022-05-15 Buy
Sigma-Aldrich 8.41611 2-Hydroxy-4-methoxybenzaldehyde for synthesis 673-22-3 25g $244 2022-05-15 Buy
TCI Chemical H0699 2-Hydroxy-4-methoxybenzaldehyde >98.0%(GC)(T) 673-22-3 5g $41 2026-04-30 Buy
Product number Packaging Price Buy
160695 5g $145 Buy
160695 25g $656 Buy
8.41611 5G $97.2 Buy
8.41611 25g $244 Buy
H0699 5g $41 Buy

2-Hydroxy-4-methoxybenzaldehyde Chemical Properties,Uses,Production

Synthesis

Paraformaldehyde (67.5 mmol) was added to a mixture of a phenolic derivative (10 mmol), anhydrous MgCl2 (1.43 g, 15 mmol), and Et3N (5.3 mL, 37.5 mmol) in THF (50 mL). The mixture was heated under reflux for 24 hours, or until the material was completely consumed at room temperature as determined by TLC. The reaction mixture was cooled to room temperature. The reaction mixture was quenched with 1 M HCl. The product was extracted with EtOAc (50 mL x 3). The organic layers were combined. The organic layers were washed with saturated brine. The organic layers were dried with Na2SO4. The organic layers were filtered. All volatiles were removed under reduced pressure. 2-Hydroxy-4-methoxybenzaldehyde was isolated by rapid chromatography (EtOAc/hexane) on silica gel.

Synthetic Route of 2-Hydroxy-4-methoxybenzaldehyde

Figure 2-Hydroxy-4-methoxybenzaldehyde

Chemical Properties

creamy white to beige or light brown cryst. powder

Uses

2-Hydroxy-4-methoxybenzaldehyde was used in the synthesis of Schiff base ligand.

Definition

ChEBI: 2-Hydroxy-4-methoxybenzaldehyde is a member of methoxybenzenes and a member of phenols.

Synthesis Reference(s)

Tetrahedron Letters, 7, p. 4153, 1966 DOI: 10.1016/0005-2760(66)90119-6

General Description

2-Hydroxy-4-methoxybenzaldehyde is the main component of root bark essential oil of Periploca sepium Bunge. It is a potential tyrosinase inhibitor present in African medicinal plants.

2-Hydroxy-4-methoxybenzaldehyde synthesis

77-78-1
95-01-2
673-22-3
Synthesis of 2-Hydroxy-4-methoxybenzaldehyde from Dimethyl sulfate and 2,4-Dihydroxybenzaldehyde

2-Hydroxy-4-methoxybenzaldehyde Preparation Products And Raw materials

Raw materials

Benzeneacetic acid, 2-hydroxy-4-methoxy- 4-Bromo-1-naphthylamine 2-Iodo-5-Methoxyphenol 5-Methoxy-2-formylphenylboronic acid 4-Hydroxy-2-methoxybenzaldehyde
2-Hydroxy-4-methoxybenzyl alcohol 2-Hydroxy-6-Methoxybenzaldehyde 2,4-Dihydroxybenzaldehyde 1,1-Dichlorodimethyl ether 2,4-Dimethoxybenzaldehyde
Isopropylamine 3-Methoxyphenol

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Preparation Products

3-Cyano-7-methoxycoumarin 3,5-Dibromo-2-hydroxy-4-methoxybenzaldehyde 2-hydroxy-4-Methoxytoluene 1-Benzofuran-6-ol 7-Methoxyisoflavone
(+)-Medicarpin 3-Acetyl-7-MethoxycouMarin

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2-Hydroxy-4-methoxybenzaldehyde Suppliers

Global( 597)Suppliers
Supplier Tel Email Country ProdList Advantage
Nanjing Hengweisheng Pharmaceutical Technology Co., Ltd 13357739131 13357739131 3991044086@qq.com China 712 58
Nanjing Daqin Pharmaceutical Technology Co., Ltd. 025-025-58470199 18351831988 sales@daqinpharma.cn China 310 58
Nanjing Thander New Material Science & Technology Co., Ltd 15384069853 2048571647@qq.com China 472 58
Shaoxing Jiufu New Material Technology Co., LTD 0575-87095566 18067860628 sales@sxjiufu.com China 413 58
Hangzhou Weirige Chemical Co., Ltd. 13093769715 yanghg@wrgchem.com China 9 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
future industrial shanghai co., ltd 400-0066400 13621662912 sales@jonln.com China 1989 65
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
Supplier Advantage
Nanjing Hengweisheng Pharmaceutical Technology Co., Ltd 58
Nanjing Daqin Pharmaceutical Technology Co., Ltd. 58
Nanjing Thander New Material Science & Technology Co., Ltd 58
Shaoxing Jiufu New Material Technology Co., LTD 58
Hangzhou Weirige Chemical Co., Ltd. 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
3B Pharmachem (Wuhan) International Co.,Ltd. 69
future industrial shanghai co., ltd 65
Alfa Aesar 84

View Lastest Price from 2-Hydroxy-4-methoxybenzaldehyde manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-hydroxy-4-methoxybenzaldehyde pictures 2026-09-02 2-hydroxy-4-methoxybenzaldehyde
673-22-3
 20kg 99% 20 tons Qingdao RENAS Polymer Material Co., Ltd.
2-Hydroxy-4-methoxybenzaldehyde pictures 2026-09-02 2-Hydroxy-4-methoxybenzaldehyde
673-22-3
 $6.00 1KG 99% Henan Fengda Chemical Co., Ltd
2-Hydroxy-4-methoxybenzaldehyde pictures 2026-08-30 2-Hydroxy-4-methoxybenzaldehyde
673-22-3
 $29.00 99.78% 10g TargetMol Chemicals Inc.

2-Hydroxy-4-methoxybenzaldehyde Spectrum

2-Hydroxy-4-methoxybenzaldehyde(673-22-3)MS2-Hydroxy-4-methoxybenzaldehyde(673-22-3)1HNMR2-Hydroxy-4-methoxybenzaldehyde(673-22-3)IR12-Hydroxy-4-methoxybenzaldehyde(673-22-3)IR22-Hydroxy-4-methoxybenzaldehyde(673-22-3)Raman

673-22-3(2-Hydroxy-4-methoxybenzaldehyde)Related Search:

3,5-Dimethoxybenzaldehyde 4-Hydroxybenzaldehyde 3-Methoxybenzaldehyde o-Anisaldehyde (Trifluoromethoxy)benzene
Veratraldehyde p-Anisidine 2,6-Dimethoxybenzaldehyde Benzaldehyde Salicylaldehyde
p-Anisaldehyde 5-Methylsalicylaldehyde Anisole 3-HYDROXY-4-METHOXYBENZALDEHYDE 2-HYDROXY-3-METHOXYBENZALDEHYDE
Vanillin Chlorophosphonazo III 3-(Methoxymethoxy)benzaldehyde

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4-METHOXYSALICYLALDEHYDE 2-HYDROXY-P-ANISALDEHYDE 2-HYDROXY-4-METHOXYBENZALDEHYDE 2-HYDROXY-4-ANISALDEHYDE 2-hydroxy-p-anisaldehyd 2-Hydroxy-4-Methoxybenzaldehyde 98% 2-Hydroxy-4-Methoxybenzaldehyde, 97+% 2-Hydroxy-4-methoxybenzaldehyde, >=98% 2-Hydroxy-4-methoxybenzaldehyde≥ 98% (GC) AKOS 222-39 4-METHOXY-2-HYDROXYBENZALDEHYDE 4-Methoxy salicylicaldehyde 2-Hydroxy-4-methoxybenzal 4-Methoxysalicyaldehyde 4-o-methylresorcylaldehyde o-Hydroxy-p-methoxybenzaldehyde p-Anisaldehyde, 2-hydroxy- Salicylaldehyde, 4-methoxy- 2-Hydroxy-4-methoxylbenzaldehyde 2-Hydroxy-p-anisaldehyde~4-Methoxysalicylaldehyde 4-MethoxySalicyladehyde 2-Hydroxyanisaldehyde 2-hydroxy-4-Methoxysalicylaldehyde Benzaldehyde, 2-hydroxy-4-methoxy- 2-Hydroxy-4-methoxyb 2-Formyl-5-methoxyphenol, 4-Formyl-3-hydroxyanisole 4-Methoxyl Salicylaldehyde 2-Hydroxy-4-Methoxybenzaldehyde, 99% 25GR 2-Hydroxy-4-Methoxybenzaldehyde, 99% 5GR 4-Methoxysalicylaldehyde(60% in NMP) 2-Formyl-5-methoxyphenol 2-Hydroxy-4-methoxybenzaldehyde,99% Hydroxy-4-Methoxybenzaldeh 2-Hydroxy-4-Methoxybenazldehyde 2-Hydroxy-4-methoxybenzaldehyde> 2-HYDROXY-4-METHOXYBENZALDEHYDE FOR SYNT 2droxy-4-methoxybenzaldeh 2-HYDROXY-4-METHOXYBENZALDEHYDE,673-22-3 Entacapone Impurity 65 673-22-3 2-Hydroxy-4-methoxybenzaldehyde 2-Hydroxy-4- Methoxybenzaldehyde (2-HMB) 2-Hydroxy-4-methoxybenzaldehyde, ≥ 98.0% 2-Hydroxy-4-methoxybenzaldehyde (Standard) 4-Mthoxysalicylaldehyde 673-22-3 673-22-32 673-22-2 672-22-3 ALDEHYDE Aldehydes Building Blocks C8 Carbonyl Compounds Chemical Synthesis Organic Building Blocks Benzaldehyde FINE Chemical & INTERMEDIATES Aromatic Aldehydes & Derivatives (substituted)