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Ethyl 2-amino-4,5-dimethylthiophene-3-carboxylate

Ethyl 2-amino-4,5-dimethylthiophene-3-carboxylate structure

CAS No.: 4815-24-1

Chemical Name:: Ethyl 2-amino-4,5-dimethylthiophene-3-carboxylate

Synonyms: AKOS 92580;AURORA 4294;AKOS B000515;AKOS MSC-0423;Ethyl 2-aMino-4;BUTTPARK 30\06-10;AKOS BBS-00002580;IFLAB-BB F0777-0822;ART-CHEM-BB B000515;TIMTEC-BB SBB005519

CBNumber:: CB2721222

Molecular Formula:: C9H13NO2S

Molecular Weight:: 199.27

MDL Number:: MFCD00085051

MOL File:: 4815-24-1.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-09-12 18:51:24

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Ethyl 2-amino-4,5-dimethylthiophene-3-carboxylate Properties

Melting point	90 °C
Boiling point	302.9±37.0 °C(Predicted)
Density	1.185±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	soluble in Methanol
pka	0.56±0.10(Predicted)
form	powder to crystal
color	White to Light yellow
λmax	310nm(MeOH)(lit.)
InChI	InChI=1S/C9H13NO2S/c1-4-12-9(11)7-5(2)6(3)13-8(7)10/h4,10H2,1-3H3
InChIKey	JYSDXODDWAQWJR-UHFFFAOYSA-N
SMILES	C1(N)SC(C)=C(C)C=1C(OCC)=O
CAS DataBase Reference	4815-24-1(CAS DataBase Reference)
FDA UNII	R50Y14M25S
UNSPSC Code	12352200

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P280a-P304+P340-P305+P351+P338-P405-P501a

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36-24/25

WGK Germany

WGK 3

HazardClass

IRRITANT

HS Code

29349990

Storage Class

11 - Combustible Solids

NFPA 704

	0
2		0

Ethyl 2-amino-4,5-dimethylthiophene-3-carboxylate price More Price(56)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	TMT00191	Ethyl 2-amino-4,5-dimethylthiophene-3-carboxylate	4815-24-1	1g	$443	2023-06-20	Buy
TCI Chemical	E1005	Ethyl 2-Amino-4,5-dimethylthiophene-3-carboxylate >98.0%(GC)(T)	4815-24-1	5g	$273	2026-04-30	Buy
TCI Chemical	E1005	Ethyl 2-Amino-4,5-dimethylthiophene-3-carboxylate >98.0%(GC)(T)	4815-24-1	25g	$1018	2026-04-30	Buy
Usbiological	159371	2-Amino-4,5-dimethyl-3-thiophenecarboxylic Acid Ethyl Ester	4815-24-1	2.5g	$403	2026-06-03	Buy
Apolloscientific	OR6145	Ethyl 2-amino-4,5-dimethylthiophene-3-carboxylate >98%	4815-24-1	5g	$21	2026-06-04	Buy

Product number	Packaging	Price	Buy
TMT00191	1g	$443	Buy
E1005	5g	$273	Buy
E1005	25g	$1018	Buy
159371	2.5g	$403	Buy
OR6145	5g	$21	Buy

Ethyl 2-amino-4,5-dimethylthiophene-3-carboxylate Chemical Properties, Uses, Production

Chemical Properties

Yellow solid

Uses

2-Amino-4,5-dimethyl-3-thiophenecarboxylic Acid Ethyl Ester is used in the preparation triazine and pyrimidine derivatives as anti-inflammatory and analgesic agents. Also used in the synthesis of antioxidants through heteroaryl amines as well as CB2 cannabinoid receptor partial agonists.

Synthesis

105-56-6

78-93-3

ETHYL 2-AMINO-4,5-DIMETHYLTHIOPHENE-3-CARBOXYLATE

4815-24-1

To a 100-mL round-bottomed flask were added 2-butanone (20 g, 0.28 mol, 1.0 eq.), ethyl cyanoacetate (31.4 g, 0.28 mol, 1.0 eq.), and sulfur powder (8.9 g, 0.28 mol, 1.0 eq.), followed by ethanol as a solvent. Diethylamine (21 g, 0.28 mol, 1.0 eq.) was added dropwise to the above mixture. The reaction system was stirred continuously for 8 hours at room temperature. After completion of the reaction, the reaction mixture was diluted with water and the resulting precipitate was collected by filtration. Purification by ethanol recrystallization afforded ethyl 2-amino-4,5-dimethylthiophene-3-carboxylate as a yellow solid (41 g, 75% yield).

References

[1] Synthetic Communications, 2012, vol. 42, # 16, p. 2367 - 2374
[2] Bulletin of the Korean Chemical Society, 2011, vol. 32, # 6, p. 2091 - 2092
[3] Organic and Biomolecular Chemistry, 2014, vol. 12, # 24, p. 4233 - 4242
[4] Journal of Sulfur Chemistry, 2014, vol. 35, # 3, p. 261 - 269
[5] Journal of Heterocyclic Chemistry, 2014, vol. 51, # SUPPL. 1, p. E216-E221

Ethyl 2-amino-4,5-dimethylthiophene-3-carboxylate Preparation Products And Raw materials

Raw materials

Sulfur N,N-Dimethylformamide 2-Butanone Triethylamine Ethyl cyanoacetate

Ethanol Diethylamine

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Preparation Products

5,6-Dimethylthieno[2,3-d]pyrimidine-4(3H)-thione 5,6-dimethyl-3-(4-methylphenyl)-2-sulfanylidene-1H-thieno[2,3-d]pyrimidin-4-one ethyl 2-(acetylamino)-4,5-dimethylthiophene-3-carboxylate Ethyl 2-isothiocyanato-4,5-dimethylthiophene-3-carboxylate (4,5-dimethyl-3-thienyl)methanol(SALTDATA: FREE)

3-Amino-5,6-dimethyl-3H-thieno[2,3-d]pyrimidin-4-one

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Ethyl 2-amino-4,5-dimethylthiophene-3-carboxylate Suppliers

Global Suppliers ( 169)

Supplier	Tel	Email	Country	ProdList	Advantage
Yancheng Orgunion Pharmaceutical Sci & Tech Co., Ltd.	0515-89701588 13770166955	orgunion@orgunion.com	China	620	55
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
INTATRADE GmbH	+49 3493/605464	sales@intatrade.de	Germany	3563	66
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
Wuhan Chemwish Technology Co., Ltd	86-027-67849912	sales@chemwish.com	China	35884	56
Beijing Ouhe Technology Co., Ltd	13552068683 13522913783	2355560935@qq.com	China	11777	60
Shanghai Sinch Parmaceuticals Tech. Co. Ltd.	+86-21-54098501	sales@sinch.com.cn	China	11592	64
Pure Chemistry Scientific Inc.	001-857-928-2050 or 1-888-588-9418	sales@chemreagents.com	United States	10174	62
Adamas Reagent, Ltd.	400-6009262 15618770481	yhx@titansci.com	China	14098	59
Tianjin heowns Biochemical Technology Co., Ltd.	400 638 7771	sales@heowns.com	China	14412	57

Supplier	Advantage
Yancheng Orgunion Pharmaceutical Sci & Tech Co., Ltd.	55
J & K SCIENTIFIC LTD.	76
INTATRADE GmbH	66
Alfa Aesar	84
Wuhan Chemwish Technology Co., Ltd	56
Beijing Ouhe Technology Co., Ltd	60
Shanghai Sinch Parmaceuticals Tech. Co. Ltd.	64
Pure Chemistry Scientific Inc.	62
Adamas Reagent, Ltd.	59
Tianjin heowns Biochemical Technology Co., Ltd.	57

View Latest Price from Ethyl 2-amino-4,5-dimethylthiophene-3-carboxylate manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-08-20	ETHYL 2-AMINO-4,5-DIMETHYLTHIOPHENE-3-CARBOXYLATE 4815-24-1	$1.10	1g	99.00%	100 Tons	Dideu Industries Group Limited
	2019-08-06	ETHYL 2-AMINO-4,5-DIMETHYLTHIOPHENE-3-CARBOXYLATE 4815-24-1	$1.00	1KG	98%	10KG	Career Henan Chemical Co

ETHYL 2-AMINO-4,5-DIMETHYLTHIOPHENE-3-CARBOXYLATE
4815-24-1
$1.10
99.00%
Dideu Industries Group Limited

ETHYL 2-AMINO-4,5-DIMETHYLTHIOPHENE-3-CARBOXYLATE
4815-24-1
$1.00
98%
Career Henan Chemical Co

Ethyl 2-amino-4,5-dimethylthiophene-3-carboxylate Spectrum

ETHYL 2-AMINO-4,5-DIMETHYLTHIOPHENE-3-CARBOXYLATE(4815-24-1)¹HNMR

4815-24-1 (Ethyl 2-amino-4,5-dimethylthiophene-3-carboxylate) Related Search:

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2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylic acid ethyl ester Ethyl 2-acetamido-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate Ethyl 2-[(2-chloroacetyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate ethyl 5-acetyl-2-amino-4-methyl-thiophene-3-carboxylate 2-Amino-4-ethyl-5-methyl-thiophene-3-carboxylic acid methyl ester

BUTTPARK 128\48-16 AKOS AUF1322 AKOS 93369 Ethyl 2-[2-(2,4-dichlorophenoxy)acetamido]-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate Ethyl 2-(((1,3-dioxoindan-2-ylidene)methyl)amino)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate

2-(3-Carboxy-propionylamino)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylic acid ethyl ester Ethyl 2-((thioxo((4-(trifluoromethoxy)phenyl)amino)methyl)amino)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate Ethyl 2-(((4-chlorophenyl)amino)carbonylamino)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate

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IFLAB-BB F0777-0822 ETHYL 2-AMINO-4,5-DIMETHYL-3-THIOPHENECARBOXYLATE ART-CHEM-BB B000515 BUTTPARK 30\06-10 AURORA 4294 2-AMINO-4,5-DIMETHYL-THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER AKOS MSC-0423 AKOS B000515 AKOS 92580 AKOS BBS-00002580 3-THIOPHENECARBOXYLIC ACID, 2-AMINO-4,5-DIMETHYL-, ETHYL ESTER OTAVA-BB BB0125270012 TIMTEC-BB SBB005519 ethyl 2-amino-4,5-dimethyl3-thenoate 2-Amino-4-ethyl-5-methyl-thiophene-3-carboxylic acid methyl ester ,97% Ethyl 2-amino-4,5-dimethylthiophene-3-carboxylate ,97% 5-diMethylthiophene-3-carboxylate Ethyl 2-aMino-4 2-Amino-4,5-dimethyl-3-(ethoxycarbonyl)thiophene, Ethyl 2-amino-4,5-dimethyl-3-thenoate 2-Amino-4,5-dimethyl-thiophen-3-carbonsaeureethylester 2-Amino-4,5-dimethyl-3-thiophenecarboxylic acid ethyl ester 4,5-Dimethyl-2-aminothiophene-3-carboxylic acid ethyl ester 2-AMINO-4,5-DIMETHYLTHIOPHENE-3-CARBOXYLATE ETHYL ESTER 2-Amino-3-(ethoxycarbonyl)-4,5-dimethylthiophene Ethyl 2-Amino-4,5-dimethylthiophene-3-carboxylate > ETHYL 2-AMINO-4,5-DIMETHYLTHIOPHENE-3-CARBOXYLATE ISO 9001：2015 REACH 2-Amini-4,5-dimethylthiophene-3-carboxylic acid ethyl ester Ethyl 2-amino-4,5-dimethylthiophene-3-carboxylate 4815-24-1 Thiophene