AMI-193
- CAS No.
- 510-74-7
- Chemical Name:
- AMI-193
- Synonyms
- spiramide;R 5808;AMI-193;Fluroxyspiramine;AMI-193, 10 mM in DMSO;8-[3-(4-FLUOROPHENOXY)PROPYL]-1-PHENYL-1,3,8-TRIAZASPIRO[4.5]-DECANONE;8-[3-(4-FLUOROPHENOXY)PROPYL]-1-PHENYL-1,3,8-TRIAZASPIRO[4.5]DECAN-4-ONE;1-Phenyl-8-[3-(4-fluorophenoxy)propyl]-1,3,8-triazaspiro[4.5]decane-4-one;1,3,8-Triazaspiro[4.5]decan-4-one, 8-[3-(4-fluorophenoxy)propyl]-1-phenyl-
- CBNumber:
- CB2728009
- Molecular Formula:
- C22H26FN3O2
- Molecular Weight:
- 383.46
- MDL Number:
- MFCD00673878
- MOL File:
- 510-74-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 176 - 179°C |
|---|---|
| storage temp. | Store at RT |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | White solid. |
| color | Off-White to Pale Yellow |
| FDA UNII | 471LF4O004 |
AMI-193 price More Price(27)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 43100 | AMI-193 ≥98% | 510-74-7 | 5mg | $80 | 2026-04-30 | Buy |
| Cayman Chemical | 43100 | AMI-193 ≥98% | 510-74-7 | 10mg | $151 | 2026-04-30 | Buy |
| Cayman Chemical | 43100 | AMI-193 ≥98% | 510-74-7 | 25mg | $317 | 2026-04-30 | Buy |
| Cayman Chemical | 43100 | AMI-193 ≥98% | 510-74-7 | 50mg | $515 | 2026-04-30 | Buy |
| Usbiological | 441342 | AMI-193 | 510-74-7 | 25mg | $638 | 2026-06-03 | Buy |
AMI-193 Chemical Properties, Uses, Production
Uses
AMI-193 is a selective 5-HT2A and D2DR receptor antagonist. Endoplasmic reticulum (ER) stress inducer; Also, it is derived from 4-Fluorophenol (F595325), which is a fluorinated phenolic compound with various applications as an starting reagent for the synthesis of pharmaceutical goods.
Definition
ChEBI: An azaspiro compound that consists of 1,3,8-triazaspiro[4.5]decan-4-one having a phenyl group attached to N-1 and a 3-(4-fluorophenoxy)propyl attached to N-8. Selective 5-HT antagonist, which binds to 5-HT2 sites as potently as spipero e but has lower affinity for 5-HT2C receptors. Also a high affinity D2 receptor antagonist (Ki = 3 nM). Lacks the disruptive effect of spiperone on animal behaviour.
Biological Activity
Selective 5-HT antagonist, which binds to 5-HT 2 sites as potently as spiperone but has lower affinity for 5-HT 2C receptors. Also a high affinity D 2 receptor antagonist (K i = 3 nM). Lacks the disruptive effect of spiperone on animal behavior.
in vivo
AMI-193 (0.003-0.01 mg/kg; i.m.) dose-dependently decreases response rate in monkeys under a fixed-interval (FI) schedule of stimulus termination[2].
AMI-193 (0.003-0.01 mg/kg; i.m.) attenuates the discriminative-stimulus effects of cocaine in drug-discrimination experiments[2].
AMI-193 (0.003-0.01 mg/kg; i.m.) reduces response rate under a second-order schedule of i.v. self-administration of cocaine (0.1 mg/infusion)[2].
| Animal Model: | Adult male squirrel monkeys (850-1300 g)[2] |
| Dosage: | 0.003, 0.01 mg/kg |
| Administration: | I.m. on Tuesday, Wednesday, and Thursday the following week |
| Result: | Decreased the response rate. The rate-decreasing effects were reversed by cocaine. |
IC 50
5-HT2 Receptor: 2 nM (Ki); D2 Receptor: 3 nM (Ki); 5-HT1A Receptor: 50 nM (Ki); D1 Receptor: 2530 nM (Ki); 5-HT1C Receptor: 4300 nM (Ki)
References
[1]. czoty pw, howell ll. behavioral effects of ami-193, a 5-ht(2a)- and dopamine d(2)-receptor antagonist, in the squirrel monkey. pharmacol biochem behav, 2000, 67(2): 257-264.
[2]. ismaiel am, de los angeles j, teitler m, et al. antagonism of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane stimulus with a newly identified 5-ht2- versus 5-ht1c-selective antagonist. j med chem, 1993, 36(17): 2519-2525.
[3]. luparini mr, garrone b, pazzagli m, et al. a cortical gaba-5ht interaction in the mechanism of action of the antidepressant trazodone. prog neuropsychopharmacol biol psychiatry, 2004, 28(7): 1117-1127.
AMI-193 Preparation Products And Raw materials
Raw materials
Preparation Products
AMI-193 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4860 | 55 | |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8435 | 60 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Shanghai Chaolan Chemical Technology Center | QQ：65489617 13301690235 | Sales@ATKchemical.com | China | 9699 | 58 |
| Shanghai Jizhi Biochemical Technology Co. Ltd. | 021-4009004166/18616739031 18616739031 | 3007523370@qq.com | China | 40000 | 58 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569266 +86-17392581500 | 1015@dideu.com | China | 3861 | 58 |
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