1-Boc-3-hydroxymethylpyrrolidine
- CAS No.
- 114214-69-6
- Chemical Name:
- 1-Boc-3-hydroxymethylpyrrolidine
- Synonyms
- TERT-BUTYL 3-(HYDROXYMETHYL)PYRROLIDINE-1-CARBOXYLATE;N-Boc-DL-beta-prolinol;N-Boc-DL-^b-prolinol, 97+%;1-Boc-3-(hydroxyMethyl)py...;N-Boc-DL-beta-prolinol, 97+%;1-BOC-3-Pyrrolidinemethanol 97%;1-BOC-3-HYDROXYMETHYLPYRROLIDINE;N-BOC--3-hydrozyMethyl-pyrroidine;3-HYDROXYMETHYL-1-BOC-PYRROLIDINE;N-Boc-3-(hydroxymethyl)pyrrolidine
- CBNumber:
- CB2737227
- Molecular Formula:
- C10H19NO3
- Molecular Weight:
- 201.26
- MDL Number:
- MFCD02179040
- MOL File:
- 114214-69-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 285-291℃ |
|---|---|
| Density | 1.089 |
| refractive index | 1.4680 to 1.4720 |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| form | clear liquid |
| pka | 14.93±0.10(Predicted) |
| color | Colorless to Light orange to Yellow |
| InChI | InChI=1S/C10H19NO3/c1-10(2,3)14-9(13)11-5-4-8(6-11)7-12/h8,12H,4-7H2,1-3H3 |
| InChIKey | HKIGXXRMJFUUKV-UHFFFAOYSA-N |
| SMILES | N1(C(OC(C)(C)C)=O)CCC(CO)C1 |
| CAS DataBase Reference | 114214-69-6(CAS DataBase Reference) |
| UNSPSC Code | 12352200 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS06,GHS09 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H410 | |||||||||
| Precautionary statements | P264-P270-P273-P301+P310-P391-P405 | |||||||||
| Hazard Codes | Xi,N,T | |||||||||
| Risk Statements | 25-50 | |||||||||
| Safety Statements | 24/25-61-45 | |||||||||
| RIDADR | 2811 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| PackingGroup | Ⅲ | |||||||||
| HS Code | 2933998090 | |||||||||
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
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| Hazard Classifications | Acute Tox. 3 Oral Aquatic Acute 1 Aquatic Chronic 1 |
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| Limited Quantities | 5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
1-Boc-3-hydroxymethylpyrrolidine price More Price(76)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | ADE000016 | 3-Hydroxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester Aldrich | 114214-69-6 | 1g | $230 | 2026-04-30 | Buy |
| TCI Chemical | B4249 | 1-(tert-Butoxycarbonyl)-3-pyrrolidinemethanol >95.0%(GC) | 114214-69-6 | 1g | $68 | 2026-04-30 | Buy |
| TCI Chemical | B4249 | 1-(tert-Butoxycarbonyl)-3-pyrrolidinemethanol >95.0%(GC) | 114214-69-6 | 5g | $237 | 2026-04-30 | Buy |
| Usbiological | 228681 | 1-Boc-3-hydroxymethylpyrrolidine | 250mg | $200 | 2026-06-03 | Buy | |
| Usbiological | 228681 | 1-Boc-3-hydroxymethylpyrrolidine | 1g | $245 | 2026-06-03 | Buy |
1-Boc-3-hydroxymethylpyrrolidine Chemical Properties, Uses, Production
Uses
1-Boc-3-hydroxymethylpyrrolidine is an intermediate of SR 9009 (S684255). SR 9009 is a synthetic REV-ERB agonist that regulates circadian behavior and metabolism; has potential use in the treatment of sleep disorders and metabolic diseases.
Synthesis
85310-69-6
24424-99-5
114214-69-6
General procedure for the synthesis of 1-Boc-3-hydroxymethylpyrrolidine from 3-pyrrolidine methanol and di-tert-butyl dicarbonate: 900 g of 3-pyrrolidine methanol was dissolved in 4.5 L of dichloromethane, and 900 g of di-tert-butyl dicarbonate and 1.8 kg of triethylamine were added in slow batch. The reaction mixture was stirred at room temperature for about 5 hours. Upon completion of the reaction, the reaction was quenched by the addition of water. The product 1-Boc-3-hydroxymethylpyrrolidine was isolated and purified by conventional post-treatment methods in 95% yield.
References
[1] Patent: CN106588738, 2017, A. Location in patent: Paragraph 0035; 0037; 0040; 0045
[2] Synlett, 2017, vol. 28, # 4, p. 425 - 428
[3] Bioorganic and medicinal chemistry letters, 2002, vol. 12, # 13, p. 1785 - 1789
[4] Bioorganic and Medicinal Chemistry Letters, 2002, vol. 12, # 21, p. 3235 - 3238
[5] Bioorganic and Medicinal Chemistry, 2004, vol. 12, # 5, p. 1151 - 1175
1-Boc-3-hydroxymethylpyrrolidine Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ITIC MEDCHEM(SUZHOU) CO.,LTD. | 0512-68323967 18015559028 | sales@iticmedchem.com | China | 528 | 61 |
| Shanghai Hobor Chemical Co., Ltd | 13918007836 | sales@hoborchem.com | China | 434 | 60 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| INTATRADE GmbH | +49 3493/605464 | sales@intatrade.de | Germany | 3563 | 66 |
| ChemFuture PharmaTech (Jiangsu) Ltd | 5108538618 | suger.wang@chemfuture.com | China | 832 | 65 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| ShangHai DEMO Chemical Co.,Ltd | 400-021-7337 2355568890 | sales@demochem.com | China | 2569 | 57 |
| Ark Pharm, Inc. | 847-367-3680 | sales@arkpharminc.com | United States | 1669 | 56 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
View Latest Price from 1-Boc-3-hydroxymethylpyrrolidine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-06-30 | 1-Boc-3-hydroxymethylpyrrolidine
114214-69-6
|
1kg | 98% | 1000kg | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2019-07-06 | 1-Boc-3-hydroxymethylpyrrolidine
114214-69-6
|
$1.00 | 1KG | 98% | 100KG | Career Henan Chemical Co |
-
- 1-Boc-3-hydroxymethylpyrrolidine
114214-69-6
- $0.00
- 98%
- Shaanxi Dideu New Materials Co. Ltd
-
- 1-Boc-3-hydroxymethylpyrrolidine
114214-69-6
- $1.00
- 98%
- Career Henan Chemical Co
