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2-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

2-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER structure

CAS No.: 170491-63-1

Chemical Name:: 2-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

Synonyms: tert-butyl 2-(hydroxymethyl)pyrrolidine-1-carboxylate;AKOS 92835;BOC-DL-PRO-AL;Boc-DL-Pro-OL;N-Boc-Prolinol;Boc-DL-Prolinol;CAS:170491-63-1;N-Boc-DL-prolinol;N-Boc-2-pyrrolidineMethanol;1-Boc-2-pyrrolidineMethanol

CBNumber:: CB0476463

Molecular Formula:: C10H19NO3

Molecular Weight:: 201.26

MDL Number:: MFCD01456556

MOL File:: 170491-63-1.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-27 22:53:06

Product description	Number	Pack Size	Price
N-(tert-Butoxycarbonyl)-DL-prolinol >98.0%(GC)	B3273	1g	$30
N-(tert-Butoxycarbonyl)-DL-prolinol >98.0%(GC)	B3273	5g	$86
tert-Butyl 2-(hydroxymethyl)pyrrolidine-1-carboxylate 97%	OR321308	5g	$55
tert-Butyl 2-(hydroxymethyl)pyrrolidine-1-carboxylate 97%	OR321308	25g	$204
N-(tert-Butoxycarbonyl)-DL-prolinol ≥98%(GC)	43814	1G	$33.45
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2-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Properties

Melting point	52-54℃
Boiling point	290℃
Density	1.084
Flash point	129℃
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
solubility	soluble in Methanol
pka	14.77±0.10(Predicted)
form	powder to crystal
color	White to Almost white
InChIKey	BFFLLBPMZCIGRM-UHFFFAOYSA-N
CAS DataBase Reference	170491-63-1

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P280a-P304+P340-P305+P351+P338-P405-P501a-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313

Risk Statements

36/37/38

Safety Statements

26-37

HS Code

29339900

NFPA 704

	1
2		0

2-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER price More Price(72)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	B3273	N-(tert-Butoxycarbonyl)-DL-prolinol >98.0%(GC)	170491-63-1	1g	$30	2026-04-30	Buy
TCI Chemical	B3273	N-(tert-Butoxycarbonyl)-DL-prolinol >98.0%(GC)	170491-63-1	5g	$86	2026-04-30	Buy
Apolloscientific	OR321308	tert-Butyl 2-(hydroxymethyl)pyrrolidine-1-carboxylate 97%	170491-63-1	5g	$55	2026-06-04	Buy
Apolloscientific	OR321308	tert-Butyl 2-(hydroxymethyl)pyrrolidine-1-carboxylate 97%	170491-63-1	25g	$204	2026-06-04	Buy
Chem-Impex	43814	N-(tert-Butoxycarbonyl)-DL-prolinol ≥98%(GC)	170491-63-1	1G	$33.45	2026-05-19	Buy

Product number	Packaging	Price	Buy
B3273	1g	$30	Buy
B3273	5g	$86	Buy
OR321308	5g	$55	Buy
OR321308	25g	$204	Buy
43814	1G	$33.45	Buy

2-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Chemical Properties,Uses,Production

Uses

N-(tert-Butoxycarbonyl)pyrrolidine-2-methanol is used to prepare 1,3-thiazolidin-2-imines derivatives as inhibitors of nitric oxide synthase.

Synthesis

24424-99-5

498-63-5

2-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

170491-63-1

Step 1. Synthesis of tert-butyl 2-hydroxymethylpyrrolidine-1-carboxylate Pyrrolidine-2-methanol (0.300 g, 1.98 mmol) was dissolved in dichloromethane (5.0 mL) and di-tert-butyl dicarbonate (0.650 g, 1.98 mmol) was added. The reaction mixture was stirred at room temperature for 16 hours. Upon completion of the reaction, the residue was purified by post-processing using Isco Combi-Flash Companion column chromatography (eluent: dichloromethane solution in 0-10% methanol) to afford tert-butyl 2-hydroxymethylpyrrolidine-1-carboxylate (0.590 g, 98% yield). 1H NMR (CDCl3, 300 MHz) δ 4.78 (br d, 1H), 4.05-3.90 (br, 1H), 3.67-3.53 (m, 2H), 3.49-3.41 (m, 1H), 3.34-3.26 (m, 1H), 2.00 (dddd, 1H), 1.85-1.72 (m, 2H). 1.60-1.50 (m, 1H), 1.46 (s, 9H).

References

[1] Patent: US2017/253569, 2017, A1. Location in patent: Paragraph 0994-0995
[2] Tetrahedron, 2005, vol. 61, # 10, p. 2631 - 2643
[3] Patent: US2016/168090, 2016, A1. Location in patent: Paragraph 0823-0824
[4] Patent: WO2011/22508, 2011, A2. Location in patent: Page/Page column 59; 60
[5] Patent: EP2202223, 2010, A1. Location in patent: Page/Page column 72-73

2-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER synthesis

Synthesis of 2-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER from Di-tert-butyl dicarbonate and 2-(Hydroxymethyl)pyrrolidine

2-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Preparation Products And Raw materials

Raw materials

1-Boc-3-hydroxymethylpyrrolidine homoproline D(-)Prolinol 2-FORMYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 1-N-BOC-2,3-DIHYDRO-PYRROLE

Methyl 1-Boc-5-oxopyrrolidine-2-carboxylate 2-(Hydroxymethyl)pyrrolidine carbon monoxide Di-tert-butyl dicarbonate DL-Proline

L-(+)-Prolinol Bromochloromethane 1-Boc-Pyrrolidine BOC-L-Proline

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Preparation Products

1-Methylpyrrolidine-2-methanol

2-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Suppliers

Global( 173)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Yanxi Chemical Co., Ltd.	+8618531123677	faithe@yan-xi.com	China	5853	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615531151365	mina@chuanghaibio.com	China	18126	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29640	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
GenicBio Limited	+86-21-37621270	service@genicbio.com	CHINA	991	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29792	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	+8613580539051	joe@yuhengpharm.com	CHINA	21142	58
GL Biochem (Shanghai) Ltd.	+86-021-61263370 +86-18901917034		CHINA	3904	58

Supplier	Advantage
Hebei Yanxi Chemical Co., Ltd.	58
Hebei Chuanghai Biotechnology Co., Ltd	58
Capot Chemical Co.,Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
GenicBio Limited	58
Accela ChemBio Inc.	58
Alchem Pharmtech,Inc.	58
career henan chemical co	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	58
GL Biochem (Shanghai) Ltd.	58

View Lastest Price from 2-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-06-27	1-Boc-2-pyrrolidinemethanol 170491-63-1		1KG	99%	500000kg	Hebei Chuanghai Biotechnology Co., Ltd
2025-06-20	1-Boc-2-pyrrolidinemethanol 170491-63-1	$2.00-100.00	1kgkg	99%	20tons	Hebei Yanxi Chemical Co., Ltd.
2019-12-26	2-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 170491-63-1	$1.00	1KG	99%	100KG	Career Henan Chemical Co

1-Boc-2-pyrrolidinemethanol
170491-63-1
$0.00
99%
Hebei Chuanghai Biotechnology Co., Ltd

1-Boc-2-pyrrolidinemethanol
170491-63-1
$2.00-100.00
99%
Hebei Yanxi Chemical Co., Ltd.

2-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
170491-63-1
$1.00
99%
Career Henan Chemical Co

2-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Spectrum

2-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(170491-63-1)¹HNMR

170491-63-1(2-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER)Related Search:

1-N-Boc-2-(hydroxymethyl)piperazine BOC-PRO-OSU BOC-L-Proline BOC-HYP(BZL)-OH N-Boc-cis-4-Hydroxy-L-proline methyl ester

N-Boc-D-proline BOC-D-PRO-OME Boc-Hyp-OH BOC-L-Prolinol (3S)-1-(tert-Butoxycarbonyl)-3-pyrrolidinecarboxylic acid

N-Boc-trans-4-Hydroxy-L-proline methyl ester BOC-OIC-OH BOC-D-PRO-OSU 3(S)-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER,(S)-3-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 3-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

(R)-3-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER,3(R)-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER (R)-2-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER BOC-HYP-OH DCHA

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AKOS 92835 2-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 1-N-BOC-2-HYDROXYMETHYLPYRROLIDINE (±)-1-Boc-pyrrolidine-2-Methanol 1-Boc-(2-HydroxyMethyl)pyrrolidine N-(tert-Butoxycarbonyl)pyrrolidine-2-methanol N-Boc-2-pyrrolidineMethanol (S)-2-(hydroxyMethyl)-1-pyrrolidinecarboxylic acid,1,1-diMethylethyl ester N-(tert-Butoxycarbonyl)-DL-prolinol 1-Boc-2-pyrrolidineMethanol Boc-DL-Prolinol 1-Boc-(2-HydroxyMethyl)pyrrolidine/Boc-DL-Pro-ol (^+)-1-Boc-pyrrolidine-2-methanol,98% 1-N-Boc-pyrrolidin-2-yl-methanol N-Boc-Prolinol BOC-DL-PRO-AL 1-Pyrrolidinecarboxylicacid, 2-(hydroxymethyl)-, 1,1-dimethylethyl ester Boc-DL-Pro-OL (^+)-1-Boc-pyrrolidine-2-methanol, 98% white powder N-(tert-Butoxycarbonyl)-DL-prolinol > 1-(tert-Butoxycarbonyl)-2-pyrrolidinemethanol N-Boc-DL-prolinol 2-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER USP/EP/BP CAS:170491-63-1 tert-butyl 2-(hydroxymethyl)pyrrolidine-1-carboxylate 170491-63-1 17049-63-1 pharmacetical