3,3',4',5,6,7-Hexahydroxyflavone
- CAS No.
- 90-18-6
- Chemical Name:
- 3,3',4',5,6,7-Hexahydroxyflavone
- Synonyms
- QUERCETAGETIN;6-Hydroxyquercetin;QUERCETAGIN;QUERCETAGENIN;6,7,4'-Quercetagetin;QUEBRACHITOL, (-)-(RG);Quercetagetin 7-glucoside;Quercetagetin, 10 mM in DMSO;3,5,6,7,3',4'-HEXAHYDROXYFLAVONE;3,3',4',5,6,7-Hexahydroxyflavone
- CBNumber:
- CB2737863
- Molecular Formula:
- C15H10O8
- Molecular Weight:
- 318.24
- MDL Number:
- MFCD00017428
- MOL File:
- 90-18-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | >300°C |
|---|---|
| Boiling point | 732.4±60.0 °C(Predicted) |
| Density | 1.912±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO : 125 mg/mL (392.79 mM; Need ultrasonic) |
| form | A crystalline solid |
| pka | 6.12±0.40(Predicted) |
| color | Light yellow to yellow |
| Cosmetics Ingredients Functions | SKIN PROTECTING |
| InChI | InChI=1S/C15H10O8/c16-6-2-1-5(3-7(6)17)15-14(22)13(21)10-9(23-15)4-8(18)11(19)12(10)20/h1-4,16-20,22H |
| InChIKey | ZVOLCUVKHLEPEV-UHFFFAOYSA-N |
| SMILES | C1(C2=CC=C(O)C(O)=C2)OC2=CC(O)=C(O)C(O)=C2C(=O)C=1O |
| LogP | 2.230 (est) |
| FDA UNII | SV68G507VO |
| UNSPSC Code | 41116107 |
| NACRES | NA.77 |
3,3',4',5,6,7-Hexahydroxyflavone price More Price(29)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PHL85766 | Quercetagetin phyproof® Reference Substance | 90-18-6 | 5 mg | $588 | 2026-04-30 | Buy |
| Sigma-Aldrich | 551590 | Quercetagetin - CAS 90-18-6 - Calbiochem A cell-permeable flavanol compound that acts a potent, ATP-competitive, and reversible inhibitor of PIM1 kinase (IC?? = 340 nM). | 90-18-6 | 5MG | $362 | 2022-05-15 | Buy |
| Cayman Chemical | 18645 | Quercetagetin ≥98% | 90-18-6 | 500μg | $81 | 2026-04-30 | Buy |
| Cayman Chemical | 18645 | Quercetagetin ≥98% | 90-18-6 | 1mg | $145 | 2026-04-30 | Buy |
| Cayman Chemical | 18645 | Quercetagetin ≥98% | 90-18-6 | 5mg | $357 | 2026-04-30 | Buy |
3,3',4',5,6,7-Hexahydroxyflavone Chemical Properties, Uses, Production
Uses
Quercetagetin (6-Hydroxyquercetin) is a flavonoid[1]. Quercetagetin is a moderately potent and selective, cell-permeable pim-1 kinase inhibitor (IC50, 0.34 μM)[2]. Anti-inflammatory and anticancer properties.
Definition
ChEBI: A hexahydroxyflavone that is flavone substituted by hydroxy groups at positions 3, 5, 6, 7, 3' and 4' respectively.
Biological Activity
Cell permeable: yes', 'Primary Target
PIM1 kinase', 'Product competes with ATP.', 'Reversible: yes', 'Target IC50: 340 nM against PIM1 kinase
in vivo
Quercetagetin significantly inhibits UVB-induced skin cancer development. Topical application of 4 or 20 nmol of Quercetagetin to mouse skin reduces tumor incidence by 32.0% and 46.7%, respectively[3].
| Animal Model: | SKH-1 hairless mice model[3] |
| Dosage: | 4 or 20 nmol |
| Administration: | Topical application; 28 weeks |
| Result: | Inhibited UVB-induced skin tumorigenesis in SKH-1 hairless mice models. Delayed the development of tumors and reduced tumor volumes in an SKH-1 hairless mice model. |
IC 50
PIM1: 0.34 μM (IC50); PIM2: 3.45 μM (IC50); RSK2: 2.82 μM (IC50); PKA: 21.2 μM (IC50)
References
[1] Yang X, et al. Isolation and identification of an antioxidant flavonoid compound from citrus-processing by-product. J Sci Food Agric. 2011 Aug 15;91(10):1925-7. DOI:10.1002/jsfa.4402
[2] Holder S, et al. Characterization of a potent and selective small-molecule inhibitor of the PIM1 kinase. Mol Cancer Ther. 2007 Jan;6(1):163-72. DOI:10.1158/1535-7163.MCT-06-0397
[3] Baek S, et al. Structural and functional analysis of the natural JNK1 inhibitor quercetagetin. J Mol Biol. 2013 Jan 23;425(2):411-23. DOI:10.1016/j.jmb.2012.10.019
3,3',4',5,6,7-Hexahydroxyflavone Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chengdu RefMedic Biotech Co Ltd | 028-82253651 18140204969 | sales@refmedic.com | China | 2258 | 58 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| ShangHai YuanYe Biotechnology Co., Ltd. | 15026964105 | shyysw007@163.com | China | 4998 | 60 |
| Chengdu Biopurify Phytochemicals Ltd. | +86-028-82633397 18982077548 | cwb1@biopurify.cn | China | 2376 | 60 |
| Shanghai Tauto Biotech Co., Ltd. | 021-51320588 | tauto@tautobiotech.com | China | 3984 | 66 |
| TargetMol Chemicals Inc. | 021-021-33632979 15002134094 | marketing@targetmol.com | China | 7993 | 58 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Wuhan ChemFaces Biochemical Co., Ltd. | 18607101326 15172504745 | aileen@chemfaces.com | China | 6904 | 55 |
| Shanghai Haozhixiang Biotechnology Co., Ltd | 526763801 13301653310 | 526763801@qq.com | China | 7983 | 55 |
| Shandong Xiya Chemical Co., Ltd. | 4009903999 13395398332 | sales@xiyashiji.com | China | 20788 | 60 |
View Latest Price from 3,3',4',5,6,7-Hexahydroxyflavone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-10 | Quercetagetin
90-18-6
|
$90.00-318.00 | 99.91% | 10g | TargetMol Chemicals Inc. | ||
 |
2019-07-06 | 3,3',4',5,6,7-HEXAHYDROXYFLAVONE
90-18-6
|
$1.00 | 1g | 99% | 100KG | Career Henan Chemical Co |
-
- Quercetagetin
90-18-6
- $90.00-318.00
- 99.91%
- TargetMol Chemicals Inc.
-
- 3,3',4',5,6,7-HEXAHYDROXYFLAVONE
90-18-6
- $1.00
- 99%
- Career Henan Chemical Co
