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ChemicalBook >> CAS DataBase List >>1,2:5,6-Bis-O-(1-methylethylidene)-D-mannitol

1,2:5,6-Bis-O-(1-methylethylidene)-D-mannitol

1,2:5,6-Bis-O-(1-methylethylidene)-D-mannitol Structure
1,2:5,6-Bis-O-(1-methylethylidene)-D-mannitol structure
CAS No.
1707-77-3
Chemical Name:
1,2:5,6-Bis-O-(1-methylethylidene)-D-mannitol
Synonyms
(1S,2S)-1,2-bis((R)-2,2-dimethyl-1,3-dioxolan-4-yl)ethane-1,2-diol;D-MANNITOL DIACETONIDE;1,2:5,6-DI-O-ISOPROPYLIDENE-D-MANNITOL;1,2,5,6-DI-O-ISOPROPYLIDENE-D-MANNITOL;DIACETONE-D-MANNITOL;1,2-bis(2,2-dimethyl-1,3-dioxolan-4-yl)-1,2-ethanediol;NSC 47987;NSC 67545;NSC 89874;DIACETONE-D-MAN
CBNumber:
CB2741824
Molecular Formula:
C12H22O6
Molecular Weight:
262.3
MDL Number:
MFCD00003211
MOL File:
1707-77-3.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-04-24 14:58:46
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1,2:5,6-Bis-O-(1-methylethylidene)-D-mannitol Properties

Melting point 120-122 °C(lit.)
alpha 6 º (c=5, Chloroform)
Boiling point 382.0±32.0 °C(Predicted)
Density 1.175±0.06 g/cm3(Predicted)
refractive index 6.5 ° (C=8, CHCl3)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility methanol: 100 mg/mL, clear, colorless
form Crystalline Powder
pka 12.98±0.20(Predicted)
color White
optical activity [α]/D +6.0±1.0°, c = 5 in chloroform
BRN 83765
InChI 1S/C12H22O6/c1-11(2)15-5-7(17-11)9(13)10(14)8-6-16-12(3,4)18-8/h7-10,13-14H,5-6H2,1-4H3/t7-,8-,9-,10-/m1/s1
InChIKey ODYBCPSCYHAGHA-ZYUZMQFOSA-N
SMILES CC1(C)OC[C@@H](O1)[C@@H](O)[C@H](O)[C@H]2COC(C)(C)O2
CAS DataBase Reference 1707-77-3(CAS DataBase Reference)
NIST Chemistry Reference D-Mannitol, 1,2:5,6-bis-o-(1-methylethylidene)-(1707-77-3)
UNSPSC Code 12352201
NACRES NA.22

SAFETY

Risk and Safety Statements

PPE Eyeshields, Gloves, type N95 (US)
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  22-24/25-36/37-26
WGK Germany  3
F  10-21
HS Code  29329990
Storage Class 11 - Combustible Solids
NFPA 704
1
1 0

1,2:5,6-Bis-O-(1-methylethylidene)-D-mannitol price More Price(61)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 296406 1,2:5,6-Di-O-isopropylidene-D-mannitol 98% 1707-77-3 5g $72.4 2023-06-20 Buy
Sigma-Aldrich 296406 1,2:5,6-Di-O-isopropylidene-D-mannitol 98% 1707-77-3 25g $182 2023-06-20 Buy
TCI Chemical D2024 1,2:5,6-Di-O-isopropylidene-D-mannitol >97.0%(GC) 1707-77-3 5g $22 2026-04-30 Buy
TCI Chemical D2024 1,2:5,6-Di-O-isopropylidene-D-mannitol >97.0%(GC) 1707-77-3 25g $59 2026-04-30 Buy
TRC TRC-D458955-5G 1,2:5,6-Di-O-isopropylidene-D-mannitol 1707-77-3 5g $59 2026-06-03 Buy
Product number Packaging Price Buy
296406 5g $72.4 Buy
296406 25g $182 Buy
D2024 5g $22 Buy
D2024 25g $59 Buy
TRC-D458955-5G 5g $59 Buy

1,2:5,6-Bis-O-(1-methylethylidene)-D-mannitol Chemical Properties, Uses, Production

Synthesis

The unsaturated ester 20 d-mannitol (19) (20 g, 0.11 mol) was added to a stirred solution of molten zinc chloride (30 g, 0.22 mol) in dry acetone (200 mL). Stirring continued until the d-mannitol was completely dissolved (22 hours). The reaction mixture was then poured into a stirred and cooled aqueous solution of K₂CO₃ (30 g, 0.22 mol) (320 mL). The precipitate was removed by filtration and thoroughly washed with DCM (200 mL). The aqueous filtrate was evaporated to remove acetone, and the extract was extracted with DCM (3 x 200 mL). The organic washes and extract were washed with cold water (100 mL), dried with MgSO₄, evaporated to a solid residue, and recrystallized to give diacetone-D-mannitol 19A as a white needle (18.3 g, 60%).

Synthesis of 1707-77-3

A solution of acetal 6a (210 mg, 0.57 mmol) in pyrrolidine (8 mL) was heated to 90°C for 48 hours. After solvent removal, the residue was purified by “rapid” column chromatography (hexane-EtOAc) to give 1,2:5,6-Bis-O-(1-methylethylidene)-D-mannitol (129 mg, 91%, 94%).

Chemical Properties

White Solid

Uses

Nebivolol intermediate.

Purification Methods

Although quite soluble in H2O, it gives a purer product when crystallised from this solvent, forming needles [Baer J Am Chem Soc 67 338 1945, NMR: Curtis et al. J Chem Soc, Perkin Trans 1 1756 1977]. [Beilstein 19/11 V 589.]

1,2:5,6-Bis-O-(1-methylethylidene)-D-mannitol synthesis

69-65-8
77-76-9
1707-77-3
Synthesis of 1,2:5,6-Bis-O-(1-methylethylidene)-D-mannitol from D-Mannitol and 2,2-Dimethoxypropane

1,2:5,6-Bis-O-(1-methylethylidene)-D-mannitol Preparation Products And Raw materials

Raw materials

D-Mannitol, 1,2:5,6-bis-O-(1-methylethylidene)-, diacetate (9CI) 2-Methoxypropene Acetone 2,2-Dimethoxypropane D-Mannitol

Preparation Products

(R)-(-)-2,2-Dimethyl-1,3-dioxolane-4-methanol (S)-(+)-(2,2-Dimethyl-[1,3]-dioxolan-4-yl)-methylamine (S)-4-Benzyloxymethyl-2,2-dimethyl-1,3-dioxolane D-Glyceraldehyde (S)-4,5-Isopropylidene-2-pentenylbromide

1,2:5,6-Bis-O-(1-methylethylidene)-D-mannitol Suppliers

Global Suppliers ( 417)
Supplier Tel Email Country ProdList Advantage
AILY INTL CHEMICAL CORP LTD 025-83208295 18913388297 ben@ailychem.com China 132 50
Zhengzhou KeYulong chemical products Co., Ltd 17319789407 17319789407 Keyulongchem@163.com China 1996 55
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TAIYUAN RHF CO.,LTD. +86 351 7031519 sales@RHFChem.com China 2334 56
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Ark Pharm, Inc. 847-367-3680 sales@arkpharminc.com United States 1669 56
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Beijing Ouhe Technology Co., Ltd 13552068683 13522913783 2355560935@qq.com China 11777 60
Supplier Advantage
AILY INTL CHEMICAL CORP LTD 50
Zhengzhou KeYulong chemical products Co., Ltd 55
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Alfa Aesar 84
TAIYUAN RHF CO.,LTD. 56
TCI (Shanghai) Development Co., Ltd. 81
Ark Pharm, Inc. 56
Energy Chemical 61
Beijing Ouhe Technology Co., Ltd 60

View Latest Price from 1,2:5,6-Bis-O-(1-methylethylidene)-D-mannitol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Diisopropylidene Mannitol pictures 2026-05-28 Diisopropylidene Mannitol
1707-77-3
 $2.00-5.00 1KG 99% 10000kg Hebei Chuanghai Biotechnology Co,.LTD
1,2:5,6-Bis-O-(1-methylethylidene)-D-mannitol pictures 2026-03-20 1,2:5,6-Bis-O-(1-methylethylidene)-D-mannitol
1707-77-3
 $10.00 1KG 99% 10 mt Hebei Chuanghai Biotechnology Co., Ltd
1,2:5,6-Bis-O-(1-methylethylidene)-D-mannitol pictures 2025-05-23 1,2:5,6-Bis-O-(1-methylethylidene)-D-mannitol
1707-77-3
 $10.00 1kg 99% 20 ton Hebei Zhuanglai Chemical Trading Co Ltd

1,2:5,6-Bis-O-(1-methylethylidene)-D-mannitol Spectrum

1,2:5,6-Bis-O-(1-methylethylidene)-D-mannitol(1707-77-3)IR1,2:5,6-Bis-O-(1-methylethylidene)-D-mannitol(1707-77-3)FT-IR1,2:5,6-Bis-O-(1-methylethylidene)-D-mannitol(1707-77-3)Raman

1707-77-3 (1,2:5,6-Bis-O-(1-methylethylidene)-D-mannitol) Related Search:

Dimethyl sulfate Dacthal Hydroxyacetone Mannitol Dimethyl sulfide
Dimethyl ether D-Mannitol Dimethyl fumarate Dimethyl carbonate Diacetone acrylamide
Diacetone Alcohol Diacetone-D-glucose Dimethyl sulfoxide N,N-Dimethylformamide Ethane
1,2,6-Hexanetriol 4-Methyl-1,3-dioxolane 3-Methoxy-1-butanol

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DIACETONE-D-MAN 1,2:5,6-ISOPROPYLIDENE-D-MANNITOL 1,2:5,6-bis-o-(1-methylethylidene)-d-mannitol 1,2:5,6-BIS-O-(1-METHYLETHYLIDENE)-D-MARNITOL 1,2-bis(2,2-dimethyl-1,3-dioxolan-4-yl)-1,2-ethanediol 1,2:5,6-Bis-O-(1-met 1,2,5,6-Di-O-isopropylidene-D-mannitol ,98% 1,2:5,6-Di-O-isopropylidene-D-maitol 1,2,5,6-Diacetone-D-Mannitol (Mannitol diacetonide) D-(+)-1,2:5,6-Di-O-isopropylideneMannitol D-Mannitol 1,2:5,6-Bis-acetonide NSC 47987 NSC 67545 NSC 89874 (1R,2R)-1,2-bis[(4S)-2,2-diMethyl-1,3-dioxolan-4-yl]ethane-1,2-diol D-Mannitol diaceton 1,2:5,6-Di-O-isopropylidene-D-Mannitol, 96%, 96% 1,2:5,6-Bis-O-(1-methylethylide (1S,2S)-1,2-bis[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]ethane-1,2-diol 5,6-Bis-O-(1-methylethylidene)-D-mannitol 1,2,5,6-DI-O-ISOPROPYLLIDINE-D-MANITOL Diacetone-D-mannitol, ≥98%,GC N'-(6-chloro-2-methoxy-9-acridinyl)ethane-1,2-diamine 1,2:5,6-Bis-o-(1-methylidene)-D-mannitol 1,2,5,6-Diisopropylidene-D-mannitol 1,2-5,6-Diacetone D-mannitol Diisopropylidene mannitol Mannitol, 1,2:5,6-di-O-isopropylidene-, D 1,2,5,6-DI-Isopopylidene-D-Mannitol Isopropylidene-D-Mannitol (2,2,2',2'-TETRAMETHYL-[4,4']BI[[1,3]DIOXOLANYL]-5-YL)-METHANOL 1 2:5 6-DI-O-ISOPROPYLIDENE-D-MANNITOL 98% 1,2:5,6-DI-O-ISOPROPYLIDINE-D-MANNITOL D-Mannitol, 1,2:5,6-bis-O-(1-methylethylidene)- (1S,2S)-1,2-Bis[(4R)-2,2-dimethyl-1,3-dioxolane-4-yl]-1,2-ethanediol (1S,2S)-1,2-Bis[(4R)-2,2-dimethyl-1,3-dioxolane-4-yl]ethylene glycol (1S,2S)-1,2-Bis[(4R)-2,2-dimethyl-1,3-dioxolane-4β-yl]ethylene glycol 1-O,2-O:5-O,6-O-Bis(1-methylethylidene)-D-mannitol Mannitol diacetonide 1,2:5,6-Di-O-isopropylidene-D-mannitol> 1,2:5,6-Di-O-isopropyL idene-D-mannitoL 1,2:5,6-Bis-O-(1-methylethylidene)-D-mannitol USP/EP/BP (+)-1,2:5,6-di-O-isopropylidene-D-mannitol 1,2:5,6- Di-o- Isopropyide- D- Manitol 1,2:5,6-Di-O-isopropylidene-D-mannitol (1S,2S)-1,2-bis((R)-2,2-dimethyl-1,3-dioxolan-4-yl)ethane-1,2-diol 1,2,5,6-DI-O-ISOPROPYLIDENE-D-MANNITOL 1,2:5,6-DI-O-ISOPROPYLIDENE-D-MANNITOL DIACETONE-D-MANNITOL D-MANNITOL DIACETONIDE 1707-77-3 C12H22O6 Specialty Synthesis Monosaccharides O-Substituted Sugars Sugar Alcohols Dioxanes & Dioxolanes