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4-Fluorophenylhydrazine hydrochloride

4-Fluorophenylhydrazine hydrochloride structure

CAS No.: 823-85-8

Chemical Name:: 4-Fluorophenylhydrazine hydrochloride

Synonyms: 1-(4-FLUOROPHENYL)HYDRAZINE HYDROCHLORIDE;BIO-FARMA BF000369;4-Fluorophenylhydraz;4-Fluorophenylhydrazinehy;P-FluoroPhenylHydrazineHcl;4-FLUOROPHENYLHYDRAZINE HCL;4-FLUOROPHENYLHYDROZINE HCL;4-fluorophenazid hydrochloride;Fluorophenylhydrazine hydrochloride;4-FLUORPHENYL HYDRAZINE HYDROCHLORIDE

CBNumber:: CB2746728

Molecular Formula:: C6H8ClFN2

Molecular Weight:: 162.59

MDL Number:: MFCD00012942

MOL File:: 823-85-8.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-07-17 18:55:08

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4-Fluorophenylhydrazine hydrochloride Properties

Melting point	≥300 °C(lit.)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
form	Powder
color	White to brownish
Water Solubility	soluble
BRN	3627721
InChI	InChI=1S/C6H7FN2.ClH/c7-5-1-3-6(9-8)4-2-5;/h1-4,9H,8H2;1H
InChIKey	FEKUXLUOKFSMRO-UHFFFAOYSA-N
SMILES	N(C1=CC=C(F)C=C1)N.[H]Cl
CAS DataBase Reference	823-85-8(CAS DataBase Reference)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06,GHS08,GHS09

Signal word

Danger

Hazard statements

H301+H311+H331-H317-H350-H410

Precautionary statements

P202-P273-P280-P301+P310-P302+P352+P312-P304+P340+P311

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Xi,Xn

Risk Statements

36/37/38-43-40-20/21/22

Safety Statements

26-36-36/37/39-22

RIDADR

2811

WGK Germany

HazardClass

IRRITANT

HS Code

29280090

Storage Class

6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects

Hazard Classifications

Acute Tox. 3 Dermal
Acute Tox. 3 Inhalation
Acute Tox. 3 Oral
Aquatic Acute 1
Aquatic Chronic 1
Carc. 1B
Skin Sens. 1

NFPA 704

	0
2		0

4-Fluorophenylhydrazine hydrochloride price More Price(90)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	F14203	4-Fluorophenylhydrazine hydrochloride 97%	823-85-8	10g	$82.8	2026-04-30	Buy
Sigma-Aldrich	F14203	4-Fluorophenylhydrazine hydrochloride 97%	823-85-8	50g	$331	2026-04-30	Buy
TCI Chemical	F0246	4-Fluorophenylhydrazine Hydrochloride >97.0%(HPLC)(T)	823-85-8	5g	$38	2026-04-30	Buy
TCI Chemical	F0246	4-Fluorophenylhydrazine Hydrochloride >97.0%(HPLC)(T)	823-85-8	25g	$181	2026-04-30	Buy
Usbiological	276014	4-Fluorophenylhydrazine HCl Asreported	823-85-8	100g	$375	2026-06-03	Buy

Product number	Packaging	Price	Buy
F14203	10g	$82.8	Buy
F14203	50g	$331	Buy
F0246	5g	$38	Buy
F0246	25g	$181	Buy
276014	100g	$375	Buy

4-Fluorophenylhydrazine hydrochloride Chemical Properties,Uses,Production

Chemical Properties

light red powde

Uses

4-Fluorophenylhydrazine hydrochloride is used as a chemical intermediate in the pharmaceutica1ls particularly of tryptamine drugs used in the treatment of migraine and cluster headaches. It is used to prepare agrochemical, and other chemical. It is used to detect sugars and aldehydes in analytical chemistry.

Synthesis

371-40-4

823-85-8

The general procedure for the synthesis of 4-fluorophenylhydrazine hydrochloride from 4-fluoroaniline was as follows: 4-fluoroaniline (127.6 g, 1 mol) was dissolved in concentrated hydrochloric acid (293 mL) and stirred for 2 hours at room temperature. Subsequently, the above solution was slowly added dropwise to a solution of sodium nitrite (72.5 g, 1.05 mol) in water (145 mL) at a temperature controlled below 5 °C. After the dropwise addition, stirring was continued for 1 hour, and then the filtrate was separated by filtration to obtain the filtrate. A solution of NaHSO3 (213.2 g, 2.05 mol) in water (500 mL) was slowly added dropwise to the filtrate over a temperature range of 0-10 °C while the pH was adjusted with 25% NaOH solution to maintain between 6-7. The reaction mixture was heated to 80 °C and maintained at this temperature for 1 hour. Upon completion of the reaction, the mixture was cooled to room temperature and then concentrated hydrochloric acid (600 mL) was added dropwise. Next, the mixture was heated to 90-100°C for 1 hour. Finally, the mixture was cooled to 10 °C and the precipitate was collected by filtration to give the light red solid product 4-fluorophenylhydrazine hydrochloride (129.3 g, 60% yield).

References

[1] European Journal of Medicinal Chemistry, 2011, vol. 46, # 7, p. 3149 - 3157
[2] Archiv der Pharmazie (Weinheim, Germany), 1994, vol. 327, # 2, p. 99 - 104
[3] Die Pharmazie, 1985, vol. 40, # 1, p. 21 - 22
[4] European Journal of Medicinal Chemistry, 2010, vol. 45, # 10, p. 4692 - 4696
[5] Angewandte Chemie - International Edition, 2010, vol. 49, # 50, p. 9769 - 9772

4-Fluorophenylhydrazine hydrochloride synthesis

Synthesis of 4-Fluorophenylhydrazine hydrochloride from 4-Bromofluorobenzene

4-Fluorophenylhydrazine hydrochloride Preparation Products And Raw materials

Raw materials

4-Bromofluorobenzene 4-Fluoroaniline 4-Fluorophenylhydrazine Hydrochloric acid Sodium nitrite

Preparation Products

5-Fluoro-2-methylindole Ethyl 1-(4-fluorophenyl)-5-methyl-1H-pyrazole-4-carboxylate 1-(4-Fluorophenyl)-5-methyl-1H-pyrazole-4-carbaldehyde 4-Fluorophenylhydrazine [1-(4-Fluorophenyl)-5-methyl-1H-pyrazol-4-yl]methanol

5-Fluoro-3-methylindole 1H-Pyrazolo[4,3-b]pyridine, 1-(4-fluorophenyl)-3-methyl- 5-Fluoro-3-isopropyl-1H-indole 1-(4-fluorophenyl)-6,7-dihydro-5H-indazol-4-one 3-tert-Butyl-1-(4-fluorophenyl)-1H-pyrazol-5-amine

Benzyl 5-fluorospiro[indoline-3,4'-piperidine]-1'-carboxylate 5-Fluoro-N,N-dimethyltryptamine 6-Fluoro-2,3,4,9-tetrahydro-1H-carbazole-3-carboxylic acid ethyl ester 6-Fluoro-2,3,4,9-tetrahydro-1H-carbazole-3-carboxylic acid 8-fluoro-2-methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole

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4-Fluorophenylhydrazine hydrochloride Suppliers

Global( 434)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Huaihua Baohua Biological Technology Co. LTD	0519-82698292	info@hhbhswkj.com	China	158	58
Taixing Kaitai Chemical Co., Ltd.	17321603069	hancheng@keytech-kt.com	China	110	58
Fuxin Kaituo Fine Chemical Technology Co., Ltd	15714082442	15714082442@163.com	China	241	58
Changshu New Venture	13776233393	janeabc@163.com	China	241	58
Chemyouth Life Science（Suzhou）Co.,Ltd	18605123100	kaiyuezhang@chemyouth.com	China	153	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
INTATRADE GmbH	+49 3493/605464	sales@intatrade.de	Germany	3563	66
future industrial shanghai co., ltd	400-0066400 13621662912	sales@jonln.com	China	1989	65
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84

Supplier	Advantage
Huaihua Baohua Biological Technology Co. LTD	58
Taixing Kaitai Chemical Co., Ltd.	58
Fuxin Kaituo Fine Chemical Technology Co., Ltd	58
Changshu New Venture	58
Chemyouth Life Science（Suzhou）Co.,Ltd	58
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
INTATRADE GmbH	66
future industrial shanghai co., ltd	65
Alfa Aesar	84

View Lastest Price from 4-Fluorophenylhydrazine hydrochloride manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-08-25	Hydrazine, (p-fluorophenyl)-, hydrochloride 823-85-8	$2.20-8.80	1kg	99%min	100kg	ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
2026-07-17	4-Fluorophenylhydrazine hydrochloride 823-85-8		1kg	98%	1000kg	Shaanxi Dideu New Materials Co. Ltd
2026-03-20	4-Fluorophenylhydrazine hydrochloride 823-85-8		1KG	99%	20 mt	Hebei Chuanghai Biotechnology Co., Ltd

Hydrazine, (p-fluorophenyl)-, hydrochloride
823-85-8
$2.20-8.80
99%min
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

4-Fluorophenylhydrazine hydrochloride
823-85-8
$0.00
98%
Shaanxi Dideu New Materials Co. Ltd

4-Fluorophenylhydrazine hydrochloride
823-85-8
99%
Hebei Chuanghai Biotechnology Co., Ltd

4-Fluorophenylhydrazine hydrochloride Spectrum

4-Fluorophenylhydrazine hydrochloride(823-85-8)MS 4-Fluorophenylhydrazine hydrochloride(823-85-8)¹HNMR 4-Fluorophenylhydrazine hydrochloride(823-85-8)¹³CNMR 4-Fluorophenylhydrazine hydrochloride(823-85-8)IR1 4-Fluorophenylhydrazine hydrochloride(823-85-8)IR2 4-Fluorophenylhydrazine hydrochloride(823-85-8)Raman

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4-Fluorophenylhydrazinehy Hydrazine, (4-fluorophenyl)-, hydrochloride 4-Fluorophenylhydraz 1-Fluoro-4-hydrazinobenzene hydrochloride (4-Fluorophenyl)hydrazine Monohydrochloride 4-Fluorophenylhydrazine hydrochloride, 97% 10GR 4 - fluorine phenylhydrazine hydrochloride 4-Fluorophenylhydrazine hydrochloride≥ 98%(HPLC) BIO-FARMA BF000369 4-FLUORPHENYL HYDRAZINE HYDROCHLORIDE 4-FLUOROPHENYLHYDRAZINE HCL 4-FLUOROPHENYLHYDRAZINE HYDROCHLORIDE P-FLUOROPHENYLHYDRAZINE HYDROCHLORIDE P-FluoroPhenylHydrazineHcl 4-FluorophenylhydrazineHydrochloride/4-FluorPhenylHydrazineHydrochloride 4-Fluorophenylhydrazinehydrochloride,98% -FLUOR PHENYL HYDRAZINE HYDROCHLORIDE 4-Fluorophenylhydrazine hydrochloride 97% 4-Fluorophenylhydrazinehydrochloride97% 4-FLUOROPHENYLHYDROZINE HCL Hydrazine, (4-fluorophenyl)-, monohydrochloride 4-FluorophenylhydrazineHydrochloride> 4-Fluorophenylhydrazine hydrochloride ISO 9001：2015 REACH Hydrazine, (p-fluorophenyl)-, hydrochloride 4-Fluorophenylhydrazine hydrochloride 823-85-8 hydrogen (4-fluorophenyl)hydrazine chloride 4-fluorophenazid hydrochloride Fluorophenylhydrazine hydrochloride 1-(4-FLUOROPHENYL)HYDRAZINE HYDROCHLORIDE 823-85-8 823-58-8 832-85-8 Building Blocks Organic Building Blocks Hydrazines Nitrogen Compounds Aryl Fluorinated Building Blocks Building Blocks Chemical Synthesis Fluorinated Building Blocks Nitrogen Compounds Organic Building Blocks Organic Fluorinated Building Blocks Other Fluorinated Organic Building Blocks Aromatic Hydrazides, Hydrazines, Hydrazones and Oximes Phenylhydrazine Hydrazines Nitrogen Compounds Organic Building Blocks FluoroCompounds Amines blocks Chemical intermediate for Flutroline 823-85-8 C6