5-Fluoro-3-methylindole
- CAS No.
- 392-13-2
- Chemical Name:
- 5-Fluoro-3-methylindole
- Synonyms
- 5-Fluoro-3-methyl-1H-indole;5-FLUORO-3-METHYLINDOLE;1H-5-Fluoro-3-methyindole;1H-5-FLUORO-3-METHYLINDOLE;1H-Indole, 5-fluoro-3-methyl-
- CBNumber:
- CB4170831
- Molecular Formula:
- C9H8FN
- Molecular Weight:
- 149.16
- MDL Number:
- MFCD03095377
- MOL File:
- 392-13-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 83.0 to 87.0 °C |
|---|---|
| Boiling point | 269.2±20.0 °C(Predicted) |
| Density | 1.219±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| form | powder to crystal |
| pka | 16.46±0.30(Predicted) |
| color | White to Light yellow to Light orange |
| InChI | InChI=1S/C9H8FN/c1-6-5-11-9-3-2-7(10)4-8(6)9/h2-5,11H,1H3 |
| InChIKey | CSDHAGJNOQIBHZ-UHFFFAOYSA-N |
| SMILES | N1C2=C(C=C(F)C=C2)C(C)=C1 |
| CAS DataBase Reference | 392-13-2(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P271-P280 | |||||||||
| Hazard Codes | Xi,T | |||||||||
| Risk Statements | 25 | |||||||||
| Safety Statements | 36/37/39-45 | |||||||||
| HS Code | 2933998090 | |||||||||
| NFPA 704 |
|
5-Fluoro-3-methylindole price More Price(59)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | F1053 | 5-Fluoro-3-methylindole >98.0%(GC) | 392-13-2 | 200mg | $50 | 2026-04-30 | Buy |
| TCI Chemical | F1053 | 5-Fluoro-3-methylindole >98.0%(GC) | 392-13-2 | 1g | $148 | 2026-04-30 | Buy |
| Biosynth | FF52320 | 5-Fluoro-3-methylindole | 392-13-2 | 2g | $150 | 2026-06-04 | Buy |
| Biosynth | FF52320 | 5-Fluoro-3-methylindole | 392-13-2 | 1g | $150 | 2026-06-04 | Buy |
| Biosynth | FF52320 | 5-Fluoro-3-methylindole | 392-13-2 | 0.5g | $150 | 2026-06-04 | Buy |
5-Fluoro-3-methylindole Chemical Properties, Uses, Production
Chemical Properties
Off-white powder
Uses
5-Fluoro-3-methylindole is used to study its ionization potential and the origin of nonexponential tryptophan fluorescnece decay in proteins.
Synthesis
2338-71-8
392-13-2
5-Fluoro-1H-indole-3-carboxaldehyde (3.2 g, 19.6 mmol) was used as raw material and dissolved in 10 mL of anhydrous tetrahydrofuran. Subsequently, lithium aluminum hydride (2.61 g, 68.6 mmol) was added to this solution. The reaction mixture was stirred at 70 °C for 2 hours. Upon completion of the reaction, the mixture was cooled to room temperature and the reaction was quenched with 18 mL of 20% sodium hydroxide aqueous solution. The mixture was extracted by adding 60 mL of dichloromethane to the mixture and the organic layer was washed with 40 mL of saturated aqueous sodium chloride solution. The organic phase was dried over anhydrous sodium sulfate and filtered, and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography with petroleum ether/ethyl acetate (V/V=50/1) as eluent to afford 5-fluoro-3-methylindole as a light yellow solid (2.41 g, 82.3% yield). The structure of the compound was confirmed by the following spectral data: mass spectrum (ESI, positive ion mode) m/z: 150.2 [M+H]+; 1H NMR (400 MHz, CDCl3) δ: 7.30-7.23 (m, 2H), 7.04 (s, 1H), 6.97 (td, J=9.0,2.0 Hz, 1H), 2.33 (s, 3H).
References
[1] Patent: WO2015/90233, 2015, A1. Location in patent: Paragraph 00362
[2] Angewandte Chemie - International Edition, 2013, vol. 52, # 11, p. 3250 - 3254
[3] Angew. Chem., 2013, vol. 125, # 11, p. 3332 - 3336,5
[4] Organic Letters, 2015, vol. 17, # 11, p. 2652 - 2655
5-Fluoro-3-methylindole Preparation Products And Raw materials
Raw materials
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Preparation Products
5-Fluoro-3-methylindole Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Wulechem Co., Ltd. | 13761914825 | wulesian@wulechem.com | China | 285 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| China DongFan Chemical Co.,LTD | 86-0571-85151182 | China | 5681 | 66 | |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
| China Langchem Inc. | 0086-21-58956006 | China | 7798 | 57 |
View Latest Price from 5-Fluoro-3-methylindole manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-12-24 | 5-Fluoro-3-methylindole
392-13-2
|
1KG | 99.0% | 1000 tons | Shaanxi Dideu Medichem Co. Ltd | ||
 |
2020-02-26 | 5-Fluoro-3-Methylindole
392-13-2
|
$1.00 | 1KG | 99%+ | 100 tons | Shaanxi Dideu Medichem Co. Ltd | |
 |
2020-02-26 | 5-Fluoro-3-methyl-1H-indole
392-13-2
|
1KG | 99.0%+ | 100 tons | Shaanxi Dideu Medichem Co. Ltd |
-
- 5-Fluoro-3-methylindole
392-13-2
- $0.10
- 99.0%
- Shaanxi Dideu Medichem Co. Ltd
-
- 5-Fluoro-3-Methylindole
392-13-2
- $1.00
- 99%+
- Shaanxi Dideu Medichem Co. Ltd
-
- 5-Fluoro-3-methyl-1H-indole
392-13-2
- 99.0%+
- Shaanxi Dideu Medichem Co. Ltd
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