4-Fluoro-3-nitrobenzenesulfonamide
- CAS No.
- 406233-31-6
- Chemical Name:
- 4-Fluoro-3-nitrobenzenesulfonamide
- Synonyms
- 4-FLUORO-3-NITRO-BENZENESULFONAMIDE;4-Fluoro-3-nitrobenzensulfonaMide;4-Fluoro-3-nitrobenzenesulphonamide;BenzenesulfonaMide, 4-fluoro-3-nitro-;4-fluoro-3-nitrobenzene-1-sulfonaMide;2-Bromo-6-(2-methyl-1,3-dioxolane-2-yl)-pyridine
- CBNumber:
- CB2790105
- Molecular Formula:
- C6H5FN2O4S
- Molecular Weight:
- 220.18
- MDL Number:
- MFCD08703185
- MOL File:
- 406233-31-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 137.0 to 141.0 °C |
|---|---|
| Boiling point | 411.1±55.0 °C(Predicted) |
| Density | 1.637 |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform, Dimethylformamide, DMSO, Methanol |
| form | Solid |
| pka | 9.39±0.60(Predicted) |
| color | Pale Yellow |
| InChI | InChI=1S/C6H5FN2O4S/c7-5-2-1-4(14(8,12)13)3-6(5)9(10)11/h1-3H,(H2,8,12,13) |
| InChIKey | FAYVDRRKPVJSPE-UHFFFAOYSA-N |
| SMILES | C1(S(N)(=O)=O)=CC=C(F)C([N+]([O-])=O)=C1 |
| CAS DataBase Reference | 406233-31-6 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| HS Code | 2935909099 | |||||||||
| NFPA 704 |
|
4-Fluoro-3-nitrobenzenesulfonamide price More Price(52)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | F1172 | 4-Fluoro-3-nitrobenzenesulfonamide >98.0%(HPLC)(N) | 406233-31-6 | 1g | $110 | 2026-04-30 | Buy |
| TCI Chemical | F1172 | 4-Fluoro-3-nitrobenzenesulfonamide >98.0%(HPLC)(N) | 406233-31-6 | 5g | $438 | 2026-04-30 | Buy |
| Usbiological | 012315 | 4-Fluoro-3-nitrobenzenesulfonamide | 406233-31-6 | 100mg | $531 | 2026-06-03 | Buy |
| Apolloscientific | PC501637 | 4-Fluoro-3-nitrobenzenesulphonamide >98% | 406233-31-6 | 5g | $21 | 2026-06-04 | Buy |
| Apolloscientific | PC501637 | 4-Fluoro-3-nitrobenzenesulphonamide >98% | 406233-31-6 | 25g | $67 | 2026-06-04 | Buy |
4-Fluoro-3-nitrobenzenesulfonamide Chemical Properties, Uses, Production
Chemical Properties
4-Fluoro-3-nitrobenzenesulfonamide is Pale Yellow Solid
Uses
Reagent used to synthesize substituted arylsulfonamide derivatives
Uses
4-Fluoro-3-nitrobenzenesulfonamide used to synthesize substituted arylsulfonamide derivatives
Synthesis
1493-27-2
406233-31-6
General procedure for the synthesis of 4-fluoro-3-nitrobenzenesulfonamide from 1-fluoro-2-nitrobenzene: 1-fluoro-2-nitrobenzene (4.0 g, 28.4 mmol) was dissolved in chlorosulfonic acid (25 mL), and the reaction was stirred at 120°C overnight. Upon completion of the reaction, it was cooled to room temperature and quenched by slow pouring into ice water. The reaction mixture was extracted with ethyl acetate (50 mL x 3), the organic layers were combined and concentrated under reduced pressure to remove the solvent. The crude product was redissolved in isopropanol and cooled to -60°C. At this temperature, ammonium hydroxide solution was added dropwise and stirring was continued for 1 hour. Subsequently, 6M hydrochloric acid (8 mL) was added to neutralize the reaction and the reaction mixture was warmed to room temperature and concentrated to dryness. The intermediate 4-fluoro-3-nitrobenzenesulfonamide (5.1 g, 82% yield) was finally obtained as a white solid.1H NMR (400 MHz, DMSO-d6) δ: 8.52 (dd, 1H), 8.20 (dq, 1H), 7.84 (dt, 1H), 7.73 (s, 2H).
References
[1] Patent: WO2017/123616, 2017, A1. Location in patent: Paragraph 00160
[2] Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 21, p. 5207 - 5211
[3] Chemistry - A European Journal, 2018, vol. 24, # 52, p. 13762 - 13766
[4] Journal of Medicinal Chemistry, 2006, vol. 49, # 3, p. 1165 - 1181
[5] Patent: US2011/237553, 2011, A1. Location in patent: Page/Page column 19
4-Fluoro-3-nitrobenzenesulfonamide Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing Habo Medical Technology Co., Ltd. | 13376080562 13376090521 | sales@habotech.com | China | 724 | 60 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Ark Pharm, Inc. | 847-367-3680 | sales@arkpharminc.com | United States | 1669 | 56 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Heterochem | 027-88041443 13072715837 | sales@hetero-chem.com | China | 695 | 58 |
| Tianjin Jinyuda Chemical Co., Ltd. | 022-58013646 13011382049 | sales@jinyudachem.com | China | 1976 | 55 |
View Latest Price from 4-Fluoro-3-nitrobenzenesulfonamide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-13 | 4-Fluoro-3-nitrobenzenesulfonamide
406233-31-6
|
$1.00 | 1g | 99% | 10000KGS | Career Henan Chemical Co |
-
- 4-Fluoro-3-nitrobenzenesulfonamide
406233-31-6
- $1.00
- 99%
- Career Henan Chemical Co
