SK33
- CAS No.
- 1928724-23-5
- Chemical Name:
- SK33
- Synonyms
- SK33;SK33, 10 mM in DMSO;3-(3,5-Bis(trifluoromethyl)phenoxy)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide;Propanamide, 3-[3,5-bis(trifluoromethyl)phenoxy]-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methyl-;Androgen Receptor,inhibit,androgen,PC3,cancer,prostate,SK 33,SK-33,Inhibitor,tissue,LNCaP,SK33,analogues,cells
- CBNumber:
- CB28054542
- Molecular Formula:
- C20H13F9N2O3
- Molecular Weight:
- 500.31
- MDL Number:
- MFCD32174353
- MOL File:
- 1928724-23-5.mol
- MSDS File:
- SDS
| Boiling point | 540.5±50.0 °C(Predicted) |
|---|---|
| Density | 1.53±0.1 g/cm3(Predicted) |
| storage temp. | 4°C, protect from light |
| solubility | DMSO : 100 mg/mL (199.88 mM; Need ultrasonic) |
| form | Solid |
| pka | 12.12±0.29(Predicted) |
| color | White to off-white |
| InChI | 1S/C20H13F9N2O3/c1-17(33,16(32)31-13-3-2-10(8-30)15(7-13)20(27,28)29)9-34-14-5-11(18(21,22)23)4-12(6-14)19(24,25)26/h2-7,33H,9H2,1H3,(H,31,32) |
| InChIKey | VJIVKRQGSGBLFP-UHFFFAOYSA-N |
| SMILES | OC(C(NC1=CC(C(F)(F)F)=C(C#N)C=C1)=O)(C)COC2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2 |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SK33 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML2460 | SK33 ≥98% (HPLC) | 1928724-23-5 | 5 mg | $95.7 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML2460 | SK33 ≥98% (HPLC) | 1928724-23-5 | 25 mg | $261.8 | 2026-04-30 | Buy |
| Biosynth | DCD72423 | SK33 | 1928724-23-5 | 5mg | $250 | 2026-06-04 | Buy |
| Biosynth | DCD72423 | SK33 | 1928724-23-5 | 10mg | $287.9 | 2026-06-04 | Buy |
| Biosynth | DCD72423 | SK33 | 1928724-23-5 | 25mg | $539.5 | 2026-06-04 | Buy |
SK33 Chemical Properties, Uses, Production
Uses
SK33, a trifluoromethylated enobosarm analog, is a potent, and tissue selective anti-androgen. SK33reduces androgen receptor (AR) transcriptional activity[1].
Biological Activity
SK33, a trifluoromethylated enobosarm analog, is a potent, and tissue selective anti-androgen. SK33reduces androgen receptor (AR) transcriptional activity[1]. In LNCaPAR+ cells, SK33, demonstrates a significantly potent activity with IC50=0.2 μM. SK33 decreases cells entering S-phase in LNCaP cells. Treatment of LNCaP/BicR cells with increasing concentrations of SK33 for 96 hours results in a dose-dependent response and an inhibition of cell growth, with IC50 of approximately 5 μM for SK33[1]. SK33 (50 mg/kg; s.c.; 24 hours) inhibits AR transcriptional activity[1].
in vivo
SK33 (50 mg/kg; s.c.; 24 hours) inhibits AR transcriptional activity[1].
| Animal Model: | ARE-Luc mice[1] |
| Dosage: | 50 mg/kg |
| Administration: | Subcutaneously; 24 hours |
| Result: | Inhibited AR transcriptional activity. |
References
[1]. Dart DA, et al. Novel Trifluoromethylated Enobosarm Analogues with Potent Antiandrogenic Activity In Vitro and Tissue Selectivity In Vivo.Mol Cancer Ther. 2018 Sep;17(9):1846-1858.
SK33 Preparation Products And Raw materials
Raw materials
Preparation Products
SK33 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 9792 | 55 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Zhejiang Huida Biotech Co., LTD | 0571-89903022 18679456698 | zilong@hizyme.com | China | 8001 | 58 |
| JinOu Biomedical (Nanjing) Co., Ltd. | 13000000000 | jinoupharma@163.com | China | 11706 | 58 |
| Bide Pharmatech Ltd. | 400-1647117 13681763483 | product02@bidepharm.com | China | 59929 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Suzhou Haiben Pharmaceutical Co., Ltd | 19353112242 | 1816280386@qq.com | China | 8041 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
| Shanghai?Medlife?Pharm-Tech?Co.,?Ltd | 4000862158 18117107507 | vip@med-life.cn | China | 4999 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 025-85560043 15850508050 | cindy.huang@synzest.com | China | 11975 | 58 |
