ChemicalBook >> CAS DataBase List >>XY028-133

XY028-133

XY028-133 structure

CAS No.: 2229974-73-4

Chemical Name:: XY028-133

Synonyms: XY028-133;XY028-133, 10 mM in DMSO;MS 28 New;L-Prolinamide, N-[7-[4-[6-[(6-acetyl-8-cyclopentyl-7,8-dihydro-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl)amino]-3-pyridinyl]-1-piperazinyl]-1,7-dioxoheptyl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-;(2S,4R)-1-((S)-2-(7-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)-7-oxoheptanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide;(2S,4R)-1-[(2S)-2-(7-{4-[6-({6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7H,8H-pyrido[2,3-d]pyrimidin-2-yl}amino)pyridin-3-yl]piperazin-1-yl}-7-oxoheptanamido)-3,3-dimethylbutanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide

CBNumber:: CB28054582

Molecular Formula:: C53H67N11O7S

Molecular Weight:: 1002.23

MDL Number:: MFCD34469555

MOL File:: 2229974-73-4.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 00:45:10

Request For Quotation

XY028-133 Properties

Density	1.307±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C, sealed storage, away from moisture and light
solubility	DMSO : 50 mg/mL (49.89 mM; Need ultrasonic)
form	Solid
pka	14.08±0.40(Predicted)
color	Light yellow to green yellow

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319
Precautionary statements	P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

XY028-133 price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	43040	MS28 ≥95%	2229974-73-4	1mg	$87	2026-04-30	Buy
Cayman Chemical	43040	MS28 ≥95%	2229974-73-4	5mg	$392	2026-04-30	Buy
Cayman Chemical	43040	MS28 ≥95%	2229974-73-4	10mg	$653	2026-04-30	Buy
Biosynth	EPD97473	XY028-133	2229974-73-4	10mg	$853.8	2026-06-04	Buy
Biosynth	EPD97473	XY028-133	2229974-73-4	25mg	$1392	2026-06-04	Buy

Product number	Packaging	Price	Buy
43040	1mg	$87	Buy
43040	5mg	$392	Buy
43040	10mg	$653	Buy
EPD97473	10mg	$853.8	Buy
EPD97473	25mg	$1392	Buy

XY028-133 Chemical Properties, Uses, Production

Uses

XY028-133 (example 14) is a PROTAC-based CDK4/6 degrader with anti-tumor activity, which consists of ligands for von Hippel-Lindau and CDK[1].

Biological Activity

XY028-133 (example 14) is a PROTAC-based CDK4/6 degrader with anti-tumor activity[1]. XY028-133 (1 and 3 μM, 24 h) significantly decreases CDK4/6, Cyclin A, PLK1 and pRb protein levels in A375 cells[1].

IC 50

CDK4; CDK6

References

[1]. JIN, Jian, et al. COMPOSITIONS AND METHODS FOR TREATING CDK4/6-MEDIATED CANCER. Patent. US2017/065027.

XY028-133 Preparation Products And Raw materials

Raw materials

Preparation Products

XY028-133 Suppliers

Global Suppliers ( 17)

Supplier	Tel	Email	Country	ProdList	Advantage
ShangHai Caerulum Pharma Discovery Co., Ltd.	18149758185 18149758185	sales-cpd@caerulumpharma.com	China	3493	58
Shanghai YuanYe Biotechnology Co., Ltd.	15026964105	2881489226@qq.com	China	89667	60
Shanghai Chaolan Chemical Technology Center	QQ：65489617 13301690235	Sales@ATKchemical.com	China	9699	58
Jilin Province Woda Biotechnology Co., Ltd.	13504435624	1927928688@qq.com	China	1644	58
TargetMol Chemicals Inc.	+1-781-999-5354; +1-00000000000	marketing@targetmol.com	United States	32431	58
Hubei wei shi reagent group ltd., company	027-59102966 18717199209	2853877583@qq.com	China	2896	58
Henan Alpha Chemical Co., Ltd.	0371-55013243 15324716602	2232176231@qq.com	China	9997	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	9067	58
Nantong QuanYi Biotechnology Co., Ltd	0513-66337626 18051384581	sales@chemhifuture.com	China	5985	58
Shanghai Aladdin Biochemical Technology Co.,Ltd.	6206333 13167063860	anhua.mao@aladdin-e.com	China	43439	58

Supplier	Advantage
ShangHai Caerulum Pharma Discovery Co., Ltd.	58
Shanghai YuanYe Biotechnology Co., Ltd.	60
Shanghai Chaolan Chemical Technology Center	58
Jilin Province Woda Biotechnology Co., Ltd.	58
TargetMol Chemicals Inc.	58
Hubei wei shi reagent group ltd., company	58
Henan Alpha Chemical Co., Ltd.	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	58
Nantong QuanYi Biotechnology Co., Ltd	58
Shanghai Aladdin Biochemical Technology Co.,Ltd.	58

XY028-133 Spectrum

XY028-133(2229974-73-4)¹HNMR

2229974-73-4 (XY028-133) Related Search:

XY028-133 Acetamide, N-[7-[(3R)-3-[[5-chloro-4-[[2-[(1-methylethyl)sulfonyl]phenyl]amino]-2-pyrimidinyl]amino]-1-piperidinyl]heptyl]-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]- Gefitinib-based PROTAC 3 VZ185 2-Pyrazinecarboxamide, 3-[[4-[1-[[1-[6-[[[(3S)-2,6-dioxo-3-piperidinyl]amino]carbonyl]-3-pyridinyl]-4-piperidinyl]methyl]-4-piperidinyl]phenyl]amino]-5-[(3R)-3-(3-methyl-2-oxo-1-imidazolidinyl)-1-piperidinyl]-

A1874

1of2

XY028-133 L-Prolinamide, N-[7-[4-[6-[(6-acetyl-8-cyclopentyl-7,8-dihydro-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl)amino]-3-pyridinyl]-1-piperazinyl]-1,7-dioxoheptyl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)- (2S,4R)-1-((S)-2-(7-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)-7-oxoheptanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (2S,4R)-1-[(2S)-2-(7-{4-[6-({6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7H,8H-pyrido[2,3-d]pyrimidin-2-yl}amino)pyridin-3-yl]piperazin-1-yl}-7-oxoheptanamido)-3,3-dimethylbutanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide MS 28 New XY028-133, 10 mM in DMSO 2229974-73-4