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SNIPER(ABL)-039

SNIPER(ABL)-039 Structure
SNIPER(ABL)-039 structure
CAS No.
2222354-29-0
Chemical Name:
SNIPER(ABL)-039
Synonyms
SNIPER(ABL)-039;5-Thiazolecarboxamide, N-(2-chloro-6-methylphenyl)-2-[[6-[4-[2-[2-[2-[2-[3-[[2-[(2S)-1-[(2S)-2-cyclohexyl-2-[[(2S)-2-(methylamino)-1-oxopropyl]amino]acetyl]-2-pyrrolidinyl]-4-thiazolyl]carbonyl]phenoxy]ethoxy]ethoxy]ethoxy]acetyl]-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-
CBNumber:
CB28054825
Molecular Formula:
C54H68ClN11O9S2
Molecular Weight:
1114.77
MDL Number:
MFCD32062728
MOL File:
2222354-29-0.mol
TDS File:
TDS
Last updated:2026-04-24 14:59:15
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SNIPER(ABL)-039 Properties

Density 1.331±0.06 g/cm3(Predicted)
pka 10.94±0.70(Predicted)

SNIPER(ABL)-039 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth XND35429 SNIPER(ABL)-039 2222354-29-0 5mg $1670.55 2026-06-05 Buy
Biosynth XND35429 SNIPER(ABL)-039 2222354-29-0 10mg $2672.8 2026-06-05 Buy
Biosynth XND35429 SNIPER(ABL)-039 2222354-29-0 25mg $5011.5 2026-06-05 Buy
Biosynth XND35429 SNIPER(ABL)-039 2222354-29-0 50mg $8018.5 2026-06-05 Buy
Product number Packaging Price Buy
XND35429 5mg $1670.55 Buy
XND35429 10mg $2672.8 Buy
XND35429 25mg $5011.5 Buy
XND35429 50mg $8018.5 Buy

SNIPER(ABL)-039 Chemical Properties,Uses,Production

Description

DAS-IAP is a novel PROTAC targeting drug-resistant BCR-ABL.

Uses

SNIPER(ABL)-039, conjugating Dasatinib (ABL inhibitor) to LCL161 derivative (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 of 10 nM. IC50s are 0.54 nM, 10 nM, 12 nM, and 50 nM for ABL, cIAP1, cIAP2, XIAP, respectively[1].

IC 50

Abl: 0.54 nM (IC50); cIAP1: 10 nM (IC50); cIAP2: 12 nM (IC50); XIAP: 50 nM (IC50); SNIPER; Abl: 10 nM (DC50)

References

[1] Shibata N, et al. Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands. Cancer Sci. 2017 Aug;108(8):1657-1666. DOI:10.1111/cas.13284

SNIPER(ABL)-039 Preparation Products And Raw materials

Raw materials

Preparation Products

SNIPER(ABL)-039 Suppliers

Global( 8)Suppliers
Supplier Tel Email Country ProdList Advantage
Sichuan Wei Keqi Biological Technology Co., Ltd. 028-81700200 18116577057 3003855609@qq.com China 7717 56
Shanghai Rlavie Technology Co., Ltd. 021-67759270 17717059219 sales@rlavie.com China 1850 55
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
Suzhou Hosyn Pharm Ltd. 17621975170; 17621975170 sales@hosynpharm.com China 1725 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 29874 58
Henan Inokai New Materials Co., Ltd 15090072163 3921118937@qq.com China 2676 58
Supplier Advantage
Sichuan Wei Keqi Biological Technology Co., Ltd. 56
Shanghai Rlavie Technology Co., Ltd. 55
TargetMol Chemicals Inc. 58
Suzhou Hosyn Pharm Ltd. 58
TargetMol Chemicals Inc. 58
Henan Inokai New Materials Co., Ltd 58

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SNIPER(ABL)-039 5-Thiazolecarboxamide, N-(2-chloro-6-methylphenyl)-2-[[6-[4-[2-[2-[2-[2-[3-[[2-[(2S)-1-[(2S)-2-cyclohexyl-2-[[(2S)-2-(methylamino)-1-oxopropyl]amino]acetyl]-2-pyrrolidinyl]-4-thiazolyl]carbonyl]phenoxy]ethoxy]ethoxy]ethoxy]acetyl]-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]- 2222354-29-0