24,25,26-Trinoroleana-1,3,5(10),7-tetraen-29-oic acid, 2,3-dihydroxy-9,13-dimethyl-, (9β,13α,14β,20α)-
- CAS No.
- 193957-88-9
- Chemical Name:
- 24,25,26-Trinoroleana-1,3,5(10),7-tetraen-29-oic acid, 2,3-dihydroxy-9,13-dimethyl-, (9β,13α,14β,20α)-
- Synonyms
- Triptohypol C;Dihydrocelastrol;DHCE. (-)-Triptohypol C;24,25,26-Trinoroleana-1,3,5(10),7-tetraen-29-oic acid, 2,3-dihydroxy-9,13-dimethyl-, (9β,13α,14β,20α)-
- CBNumber:
- CB28125802
- Molecular Formula:
- C29H40O4
- Molecular Weight:
- 452.64
- MDL Number:
- MOL File:
- 193957-88-9.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319 |
| Precautionary statements | P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330 |
24,25,26-Trinoroleana-1,3,5(10),7-tetraen-29-oic acid, 2,3-dihydroxy-9,13-dimethyl-, (9β,13α,14β,20α)- price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0066075 | Triptohypol C 96.56% | 193957-88-9 | 5mg | $336 | 2026-06-04 | Buy |
| ChemScene | CS-0066075 | Triptohypol C 96.56% | 193957-88-9 | 10mg | $542 | 2026-06-04 | Buy |
| aablocks | AA024RUE | Triptohypol C >98% | 193957-88-9 | 5mg | $380 | 2026-06-01 | Buy |
| aablocks | AA024RUE | Triptohypol C >98% | 193957-88-9 | 10mg | $591 | 2026-06-01 | Buy |
| Arctom | HY-117469 | Triptohypol C 96.56% | 193957-88-9 | 5mg | $295 | 2026-05-26 | Buy |
24,25,26-Trinoroleana-1,3,5(10),7-tetraen-29-oic acid, 2,3-dihydroxy-9,13-dimethyl-, (9β,13α,14β,20α)- Chemical Properties, Uses, Production
Uses
Triptohypol C, a Tripterin (HY-13067) derivative, is a potent Nur77-targeting anti-inflammatory agent with an Kd value of 0.87 μM. Triptohypol C inhibits inflammatory response by promoting the interactions of Nur77 with TRAF2 and p62/SQSTM1[1].
Definition
ChEBI: Triptohypol C is a pentacyclic triterpenoid with formula C29H40O4, originally isolated from the root bark of Tripterygium regelii. It has a role as a plant metabolite and an apoptosis inducer. It is a pentacyclic triterpenoid, a monocarboxylic acid and a member of benzenediols.
in vivo
Caused 3.12% apoptosis in cells, which was less cytotoxic than Tripterin (>10%).
| Animal Model: | Zebrafish[1] |
| Dosage: | 0.5μM, 1μM and 1.25μM |
| Administration: | 72 h |
| Result: | Had less effect than Tripterin on the death rate and malformation of zebrafish either at a concentration of 1.25μM for 24h or at a concentration of 0.5μM for 72h. |
IC 50
Nur77/NR4A1
References
[1] Chen Z, et al. SAR study of celastrol analogs targeting Nur77-mediated inflammatory pathway. Eur J Med Chem. 2019 Sep 1;177:171-187. DOI:10.1016/j.ejmech.2019.05.009
24,25,26-Trinoroleana-1,3,5(10),7-tetraen-29-oic acid, 2,3-dihydroxy-9,13-dimethyl-, (9β,13α,14β,20α)- Preparation Products And Raw materials
Raw materials
Preparation Products
24,25,26-Trinoroleana-1,3,5(10),7-tetraen-29-oic acid, 2,3-dihydroxy-9,13-dimethyl-, (9β,13α,14β,20α)- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
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| Chengdu Push Bio-Technology Co., Ltd. | 028-85370565-229 18080489829 | 18080489829@163.com | China | 8379 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Shanghai Taopu Industrial Co., LTD | 15900573766 18018507602 | 3165608826@qq.com | China | 4404 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Naturewill Biotechnology Co., Ltd. | 028-82632533 18113192475 | 3157321941@qq.com | China | 4993 | 58 |
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| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
| Hubei CuiRan Biotechnology Co., Ltd. | 18162795156 18162795156 | 3391961471@qq.com | China | 4967 | 58 |
| RENI Pharmaceutical Technology Co., Ltd | 028-87865381 18108190480 | 3961643053@qq.com | China | 4321 | 58 |
