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ChemicalBook >> CAS DataBase List >>L-Threonine, N-[2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl]acetyl]-D-phenylalanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-threonyl-L-cysteinyl-, cyclic (2→7)-disulfide

L-Threonine, N-[2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl]acetyl]-D-phenylalanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-threonyl-L-cysteinyl-, cyclic (2→7)-disulfide

L-Threonine, N-[2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl]acetyl]-D-phenylalanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-threonyl-L-cysteinyl-, cyclic (2→7)-disulfide Structure
L-Threonine, N-[2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl]acetyl]-D-phenylalanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-threonyl-L-cysteinyl-, cyclic (2→7)-disulfide structure
CAS No.
177943-88-3
Chemical Name:
L-Threonine, N-[2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl]acetyl]-D-phenylalanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-threonyl-L-cysteinyl-, cyclic (2→7)-disulfide
Synonyms
24Dotatate;Synonyms: Oxodotreotide;Polypeptide Impurity 32;DOTA-TATE, DOTA-[Tyr3]-Octreotate;L-Threonine, N-[2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl]acetyl]-D-phenylalanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-threonyl-L-cysteinyl-, cyclic (2→7)-disulfide
CBNumber:
CB28182283
Molecular Formula:
C65H90N14O19S2
Molecular Weight:
1435.63
MDL Number:
MFCD19443981
MOL File:
177943-88-3.mol
MSDS File:
SDS
Last updated:2025-06-18 16:39:24
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L-Threonine, N-[2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl]acetyl]-D-phenylalanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-threonyl-L-cysteinyl-, cyclic (2→7)-disulfide Properties

Boiling point 1738.9±65.0 °C(Predicted)
Density 1.48±0.1 g/cm3(Predicted)
solubility DMSO (Slightly, Heated), Methanol (Slightly)
pka 1.83±0.10(Predicted)
form Solid
color White to Off-White
Sequence {DOTA}-{d-Phe}-Cys-Tyr-{d-Trp}-Lys-Thr-Cys-Thr (Disulfide bridge:Cys2-Cys7)
Stability Hygroscopic
FDA UNII MRL3739G66

L-Threonine, N-[2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl]acetyl]-D-phenylalanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-threonyl-L-cysteinyl-, cyclic (2→7)-disulfide price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemPep 180909-5MG DOTA-TATE 177943-88-3 5mg $500 2026-06-04 Buy
ChemPep 180909-25MG DOTA-TATE 177943-88-3 25mg $800 2026-06-04 Buy
ChemPep 180909-1MG DOTA-TATE 177943-88-3 1mg $200 2026-06-04 Buy
ChemPep 180909-100MG DOTA-TATE 177943-88-3 100mg $1050 2026-06-04 Buy
ChemScene CS-0025403 DOTATATE 99.95% 177943-88-3 1mg $87 2026-06-04 Buy
Product number Packaging Price Buy
180909-5MG 5mg $500 Buy
180909-25MG 25mg $800 Buy
180909-1MG 1mg $200 Buy
180909-100MG 100mg $1050 Buy
CS-0025403 1mg $87 Buy

L-Threonine, N-[2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl]acetyl]-D-phenylalanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-threonyl-L-cysteinyl-, cyclic (2→7)-disulfide Chemical Properties, Uses, Production

Uses

DOTATATE is a DOTA-conjugated peptide. DOTATATE can be labelled with radionuclides for positron emission tomography (PET) imaging and peptide receptor radionuclide research (PRRT)[1][2][3][4]. DOTATATE can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).

in vivo

177Lu-DOTATATE shows excellent antitumor effects in rats[1].

IC 50

RDC Peptide

References

[1] Jong M, et, al. Combination radionuclide therapy using 177Lu- and 90Y-labeled somatostatin analogs. J Nucl Med. 2005 Jan;46 Suppl 1:13S-7S. PMID:15653647
[2] Gains JE, et, al. 68Ga-DOTATATE and 123I-mIBG as imaging biomarkers of disease localisation in metastatic neuroblastoma: implications for molecular radiotherapy. Nucl Med Commun. 2020 Aug 10. DOI:10.1097/MNM.0000000000001265
[3] Breeman WAP, et, al. Optimising conditions for radiolabelling of DOTA-peptides with 90Y, 111In and 177Lu at high specific activities. Eur J Nucl Med Mol Imaging. 2003 Jun;30(6):917-20. DOI:10.1007/s00259-003-1142-0
[4] Reubi JC, et, al. Affinity profiles for human somatostatin receptor subtypes SST1-SST5 of somatostatin radiotracers selected for scintigraphic and radiotherapeutic use. Eur J Nucl Med. 2000 Mar;27(3):273-82. DOI:10.1007/s002590050034

L-Threonine, N-[2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl]acetyl]-D-phenylalanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-threonyl-L-cysteinyl-, cyclic (2→7)-disulfide Preparation Products And Raw materials

Raw materials

Preparation Products

L-Threonine, N-[2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl]acetyl]-D-phenylalanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-threonyl-L-cysteinyl-, cyclic (2→7)-disulfide Suppliers

Global Suppliers ( 15)
Supplier Tel Email Country ProdList Advantage
Shanghai Chaolan Chemical Technology Center QQ：65489617 13301690235 Sales@ATKchemical.com China 9729 58
Hangzhou Peptidego Biotech Co.,Ltd. 0571-87213919 15967184799 Eric@peptidego.com China 7872 58
Dideu Industries Group Limited +8617392712697 1022@dideu.com China 29089 58
BOC Sciences 16314854226; +8616314854226 inquiry@bocsci.com United States 19852 58
Hangzhou Go Top Peptide Biotech 0571-88211921 17357109671 sales3@gotopbio.com China 2988 58
Chengdu Junepharma Technology Co., Ltd 19181793067 1486288711@qq.com China 250 58
Hangzhou Sinoda Pharmaceutical Technology Co. LTD 0571-87213919 17306812703 3007955328@qq.com China 7446 58
Combio (Suzhou) Ltd. 17751201929; 17751201929 jianyang_yu@combiosz.com China 2989 58
PharmaBlock Sciences (Nanjing), Inc. 4000255188 sales@pharmablock.com China 7266 58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 025-025-66113011 15955137747 cb5@aikonchem.com China 10354 58
Supplier Advantage
Shanghai Chaolan Chemical Technology Center 58
Hangzhou Peptidego Biotech Co.,Ltd. 58
Dideu Industries Group Limited 58
BOC Sciences 58
Hangzhou Go Top Peptide Biotech 58
Chengdu Junepharma Technology Co., Ltd 58
Hangzhou Sinoda Pharmaceutical Technology Co. LTD 58
Combio (Suzhou) Ltd. 58
PharmaBlock Sciences (Nanjing), Inc. 58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 58

177943-88-3 (L-Threonine, N-[2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl]acetyl]-D-phenylalanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-threonyl-L-cysteinyl-, cyclic (2→7)-disulfide) Related Search:

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D-Tyrosinamide, 4-chloro-N-[2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl]acetyl]-L-phenylalanyl-D-cysteinyl-4-[[[(4S)-hexahydro-2,6-dioxo-4-pyrimidinyl]carbonyl]amino]-L-phenylalanyl-4-[(aminocarbonyl)amino]-D-phenylalanyl-L-lysyl-L-threonyl-L-cysteinyl-, cyclic (2→7)-disulfide

1of2

L-Threonine, N-[2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl]acetyl]-D-phenylalanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-threonyl-L-cysteinyl-, cyclic (2→7)-disulfide DOTA-TATE, DOTA-[Tyr3]-Octreotate Polypeptide Impurity 32 Synonyms: Oxodotreotide 24Dotatate 177943-88-3