DOTAGA-Anhydride
- CAS No.
- 1375475-53-8
- Chemical Name:
- DOTAGA-Anhydride
- Synonyms
- 2,2',2''-(10-(2,6-Dioxotetrahydro-2H-pyran-3-yl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid;DOTAGA-Anhydride;10-(Tetrahydro-2,6-dioxo-2H-pyran-3-yl)-1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid;1,4,7,10-Tetraazacyclododecane-1,4,7-triacetic acid, 10-(tetrahydro-2,6-dioxo-2H-pyran-3-yl)-
- CBNumber:
- CB14813614
- Molecular Formula:
- C19H30N4O9
- Molecular Weight:
- 458.46
- MDL Number:
- MFCD33403099
- MOL File:
- 1375475-53-8.mol
- MSDS File:
- SDS
| Boiling point | 752.4±60.0 °C(Predicted) |
|---|---|
| Density | 1.356±0.06 g/cm3(Predicted) |
| form | Solid |
| pka | 2.46±0.10(Predicted) |
| color | White to off-white |
| InChI | InChI=1S/C19H30N4O9/c24-15(25)11-20-3-5-21(12-16(26)27)7-9-23(14-1-2-18(30)32-19(14)31)10-8-22(6-4-20)13-17(28)29/h14H,1-13H2,(H,24,25)(H,26,27)(H,28,29) |
| InChIKey | BYBCIVKIWIFVFD-UHFFFAOYSA-N |
| SMILES | N1(CC(O)=O)CCN(C2CCC(=O)OC2=O)CCN(CC(O)=O)CCN(CC(O)=O)CC1 |
DOTAGA-Anhydride price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0120847 | DOTAGA-anhydride ≥98% | 1375475-53-8 | 5mg | $100 | 2026-06-04 | Buy |
| ChemScene | CS-0120847 | DOTAGA-anhydride ≥98% | 1375475-53-8 | 10mg | $166 | 2026-06-04 | Buy |
| ChemScene | CS-0120847 | DOTAGA-anhydride ≥98% | 1375475-53-8 | 25mg | $350 | 2026-06-04 | Buy |
| ChemScene | CS-0120847 | DOTAGA-anhydride ≥98% | 1375475-53-8 | 50mg | $563 | 2026-06-04 | Buy |
| ChemScene | CS-0120847 | DOTAGA-anhydride ≥98% | 1375475-53-8 | 100mg | $877 | 2026-06-04 | Buy |
DOTAGA-Anhydride Chemical Properties,Uses,Production
Uses
DOTAGA-anhydride is a DOTA-based metal chelator that can bind to radionuclides and is used to prepare radionuclide drug conjugates (RDCs). DOTAGA-anhydride can be used to label monoclonal antibodies (mAbs) such as trastuzumab (targeting HER2/neu receptor with an affinity of 5.5 nM) under mild conditions (PBS pH 7.4, 25 °C, 30 minutes) after chelation with indium-111. [111In-DOTAGA]-trastuzumab showed a tumor uptake of 65% ID/g in mice bearing breast cancer BT-474 xenografts 72 hours after injection, which is valuable for SPECT/CT imaging and biodistribution studies.
IC 50
RDC Bifunctional Chelator
DOTAGA-Anhydride Preparation Products And Raw materials
Raw materials
Preparation Products
DOTAGA-Anhydride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Changzhou Hopschain Chemical Co.,Ltd. | 85528066 13775048983 | sales@hopschem.com | China | 31548 | 55 |
| Shanghai Youde Chemical Technology Co., Ltd. | 021-37910267 15821801668 | sales@udchem.com | China | 1216 | 58 |
| Nanchang Tianzhen Biotechnology Co., Ltd | 13758194781 13173652190 | 522013271@qq.com | China | 2447 | 58 |
| Nantong Hi-Future Biotechnology Co., Ltd | +86-0513; 18051384581 | sales@chemhifuture.com | China | 3075 | 58 |
| Xi'an Kaixin Biotechnology Co., Ltd | 029-68881181 13619217766 | 3495811982@qq.com | China | 2816 | 58 |
| Xi'an Qiyue Biotechnology Co., Ltd. | 400-400-6966-012-012 17778955912 | 2957605606@qq.com | China | 3988 | 58 |
| Unibest Pharmaceutical Technology Co., Ltd. | 13735578103 | jzyz@unibestpharma.com | China | 138 | 58 |
| Lianhe Aigen Pharmatech Co.,Ltd. | 18918657159 | sales-Aigen@lianhetech.com | China | 2998 | 58 |
| Jilin Chinese Academy of Sciences-yanshen Technology | 18143011203 | ET-market@chemextension.com | China | 38862 | 58 |
| Henan Yinuokai New Materials Co., Ltd | 15565215982 15565215982 | 15565215982@163.com | China | 3744 | 58 |
