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ChemicalBook >> CAS DataBase List >>1H-Indole-2-carboxamide, 6-fluoro-N-[6-[4-(1-methylethyl)-4H-1,2,4-triazol-3-yl]-2-pyridinyl]-

1H-Indole-2-carboxamide, 6-fluoro-N-[6-[4-(1-methylethyl)-4H-1,2,4-triazol-3-yl]-2-pyridinyl]-

1H-Indole-2-carboxamide, 6-fluoro-N-[6-[4-(1-methylethyl)-4H-1,2,4-triazol-3-yl]-2-pyridinyl]- Structure
1H-Indole-2-carboxamide, 6-fluoro-N-[6-[4-(1-methylethyl)-4H-1,2,4-triazol-3-yl]-2-pyridinyl]- structure
CAS No.
2541792-70-3
Chemical Name:
1H-Indole-2-carboxamide, 6-fluoro-N-[6-[4-(1-methylethyl)-4H-1,2,4-triazol-3-yl]-2-pyridinyl]-
Synonyms
ASK1-IN-2;ASK1-IN-2, 10 mM in DMSO;6-fluoro-N-(6-(4-isopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-1H-indole-2-carboxamide;1H-Indole-2-carboxamide, 6-fluoro-N-[6-[4-(1-methylethyl)-4H-1,2,4-triazol-3-yl]-2-pyridinyl]-;colitis,ulcerative,signal-regulating,ASK1 IN 2,ASK1IN2,inhibit,MAP kinase kinase kinase, MEKK, MAPKKK,Apoptosis,ASK1,Inhibitor,ASK-1-IN-2,MAP3K
CBNumber:
CB28239271
Molecular Formula:
C19H17FN6O
Molecular Weight:
364.38
MDL Number:
MFCD33548891
MOL File:
2541792-70-3.mol
Last updated:2025-04-18 09:51:55
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1H-Indole-2-carboxamide, 6-fluoro-N-[6-[4-(1-methylethyl)-4H-1,2,4-triazol-3-yl]-2-pyridinyl]- Properties

Density 1.41±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 250 mg/mL (686.10 mM; Need ultrasonic)
form Solid
pka 12.33±0.70(Predicted)
color White to off-white

1H-Indole-2-carboxamide, 6-fluoro-N-[6-[4-(1-methylethyl)-4H-1,2,4-triazol-3-yl]-2-pyridinyl]- price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0145639 ASK1-IN-2 98.49% 2541792-70-3 5mg $350 2021-12-16 Buy
ChemScene CS-0145639 ASK1-IN-2 98.49% 2541792-70-3 10mg $580 2021-12-16 Buy
ChemScene CS-0145639 ASK1-IN-2 98.49% 2541792-70-3 25mg $1100 2021-12-16 Buy
ChemScene CS-0145639 ASK1-IN-2 98.49% 2541792-70-3 50mg $1700 2021-12-16 Buy
ChemScene CS-0145639 ASK1-IN-2 98.49% 2541792-70-3 100mg $2500 2021-12-16 Buy
Product number Packaging Price Buy
CS-0145639 5mg $350 Buy
CS-0145639 10mg $580 Buy
CS-0145639 25mg $1100 Buy
CS-0145639 50mg $1700 Buy
CS-0145639 100mg $2500 Buy

1H-Indole-2-carboxamide, 6-fluoro-N-[6-[4-(1-methylethyl)-4H-1,2,4-triazol-3-yl]-2-pyridinyl]- Chemical Properties,Uses,Production

Uses

ASK1-IN-2 is a potent and orally active inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with an IC50 of 32.8 nM. ASK1-IN-2 can be used for the research of ulcerative colitis[1].

in vivo

ASK1-IN-2 (25 mg/kg; p.o. daily for 7 d) improves dextran sulphate sodium (DSS)-induced ulcerative colitis (UC) in mice[1].
ASK1-IN-2 (25 mg/kg; p.o. daily for 7 d) blocks ASK1-p38/JNK signaling pathways and reduces inflammatory cytokine levels in DSS-induced mouse colon tissues[1].
ASK1-IN-2 (1 mg/kg; i.v.) shows low clearance (CL=1.38 L/h/kg) and moderate half-life (T1/2=1.45 h) in rats[1].
ASK1-IN-2 (10 mg/kg; p.o.) shows high oral exposure (AUClast=4517 h?ng/mL), 62.2% oral bioavailability and acceptable terminal half-life (T1/2=2.31 h) in rats[1].

Animal Model:Male ICR mice (18-22 g, 6-8 weeks) were given 3% DSS (w/v) orally in drinking water[1]
Dosage:25 mg/kg
Administration:P.o. daily for 7 days
Result:Induced a significant recovery of body weight loss, with an increase of +11.2%.
Decreased the disease activity index (DAI) score about a 2 unit.
Significantly prevented colon shortening.
Attenuated a severe colonic tissue damage and infiltration of inflammatory cells.
Animal Model:Male SD rats [1]
Dosage:1 mg/kg for i.v.; 10 mg/kg for p.o. (Pharmacokinetic Analysis)
Administration:I.v. and p.o. administration
Result:I.v.: CL=1.38 L/h/kg; T1/2=1.45 h.
P.o.: AUClast=4517 h?ng/mL; F=62.2%; T1/2=2.31 h.

IC 50

ASK1: 32.8 nM (IC50)

References

[1] Hou S, et, al. Structure-based discovery of 1H-indole-2-carboxamide derivatives as potent ASK1 inhibitors for potential treatment of ulcerative colitis. Eur J Med Chem. 2020 Dec 24;211:113114. DOI:10.1016/j.ejmech.2020.113114

1H-Indole-2-carboxamide, 6-fluoro-N-[6-[4-(1-methylethyl)-4H-1,2,4-triazol-3-yl]-2-pyridinyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

1H-Indole-2-carboxamide, 6-fluoro-N-[6-[4-(1-methylethyl)-4H-1,2,4-triazol-3-yl]-2-pyridinyl]- Suppliers

Global( 21)Suppliers
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TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32268 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38663 58
Aladdin Scientific 		tp@aladdinsci.com United States 52924 58
BOC Sciences 1-631-485-4226; 16314854226 info@bocsci.com United States 12952 65
Zhengzhou HSH Science & Technology Co., Ltd. 0371-55932928 18937192232 1282296214@qq.com China 495 55
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4611 55
Shanghai Beckham Medical Technology Co., Ltd 021-13816613772 13816613772 huahero21@sina.com China 996 55
ShangHai Biochempartner Co.,Ltd 17754423994 17754423994 2853530910@QQ.com China 8011 62
Shanghai Chaolan Chemical Technology Center 021-QQ：65489617 15618227136 Sales@ATKchemical.com China 9342 58
Shandong Jirun Biomedical Technology Co., Ltd. 0539-0539-8613587 17661611089 2639273505@qq.com China 185 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
TargetMol Chemicals Inc. 		58
Aladdin Scientific 		58
BOC Sciences 65
Zhengzhou HSH Science & Technology Co., Ltd. 55
Shanghai Lollane Biological Technology Co.,Ltd. 55
Shanghai Beckham Medical Technology Co., Ltd 55
ShangHai Biochempartner Co.,Ltd 62
Shanghai Chaolan Chemical Technology Center 58
Shandong Jirun Biomedical Technology Co., Ltd. 58

View Lastest Price from 1H-Indole-2-carboxamide, 6-fluoro-N-[6-[4-(1-methylethyl)-4H-1,2,4-triazol-3-yl]-2-pyridinyl]- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
ASK1-IN-2 pictures 2024-11-19 ASK1-IN-2
2541792-70-3
 US $68.00-263.00 / mg 98.79% 10g TargetMol Chemicals Inc.
  • ASK1-IN-2 pictures
  • ASK1-IN-2
    2541792-70-3
  • US $68.00-263.00 / mg
  • 98.79%
  • TargetMol Chemicals Inc.
1H-Indole-2-carboxamide, 6-fluoro-N-[6-[4-(1-methylethyl)-4H-1,2,4-triazol-3-yl]-2-pyridinyl]- 6-fluoro-N-(6-(4-isopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-1H-indole-2-carboxamide ASK1-IN-2 colitis,ulcerative,signal-regulating,ASK1 IN 2,ASK1IN2,inhibit,MAP kinase kinase kinase, MEKK, MAPKKK,Apoptosis,ASK1,Inhibitor,ASK-1-IN-2,MAP3K ASK1-IN-2, 10 mM in DMSO 2541792-70-3