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ChemicalBook >> CAS DataBase List >>1H-Indole-2-carboxamide, 6-fluoro-N-[6-[4-(1-methylethyl)-4H-1,2,4-triazol-3-yl]-2-pyridinyl]-

1H-Indole-2-carboxamide, 6-fluoro-N-[6-[4-(1-methylethyl)-4H-1,2,4-triazol-3-yl]-2-pyridinyl]-

1H-Indole-2-carboxamide, 6-fluoro-N-[6-[4-(1-methylethyl)-4H-1,2,4-triazol-3-yl]-2-pyridinyl]- Structure
1H-Indole-2-carboxamide, 6-fluoro-N-[6-[4-(1-methylethyl)-4H-1,2,4-triazol-3-yl]-2-pyridinyl]- structure
CAS No.
2541792-70-3
Chemical Name:
1H-Indole-2-carboxamide, 6-fluoro-N-[6-[4-(1-methylethyl)-4H-1,2,4-triazol-3-yl]-2-pyridinyl]-
Synonyms
ASK1-IN-2;ASK1-IN-2, 10 mM in DMSO;6-fluoro-N-(6-(4-isopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-1H-indole-2-carboxamide;1H-Indole-2-carboxamide, 6-fluoro-N-[6-[4-(1-methylethyl)-4H-1,2,4-triazol-3-yl]-2-pyridinyl]-;colitis,ulcerative,signal-regulating,ASK1 IN 2,ASK1IN2,inhibit,MAP kinase kinase kinase, MEKK, MAPKKK,Apoptosis,ASK1,Inhibitor,ASK-1-IN-2,MAP3K
CBNumber:
CB28239271
Molecular Formula:
C19H17FN6O
Molecular Weight:
364.38
MDL Number:
MFCD33548891
MOL File:
2541792-70-3.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-27 17:00:41
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1H-Indole-2-carboxamide, 6-fluoro-N-[6-[4-(1-methylethyl)-4H-1,2,4-triazol-3-yl]-2-pyridinyl]- Properties

Density 1.41±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 250 mg/mL (686.10 mM; Need ultrasonic)
pka 12.33±0.70(Predicted)
form Solid
color White to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319
Precautionary statements  P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

1H-Indole-2-carboxamide, 6-fluoro-N-[6-[4-(1-methylethyl)-4H-1,2,4-triazol-3-yl]-2-pyridinyl]- price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth RBE79270 ASK1-IN-2 2541792-70-3 25mg $1382.75 2026-06-05 Buy
Biosynth RBE79270 ASK1-IN-2 2541792-70-3 50mg $1923.5 2026-06-05 Buy
ChemScene CS-0145639 ASK1-IN-2 99.37% 2541792-70-3 5mg $217 2026-06-04 Buy
ChemScene CS-0145639 ASK1-IN-2 99.37% 2541792-70-3 10mg $347 2026-06-04 Buy
ChemScene CS-0145639 ASK1-IN-2 99.37% 2541792-70-3 25mg $624 2026-06-04 Buy
Product number Packaging Price Buy
RBE79270 25mg $1382.75 Buy
RBE79270 50mg $1923.5 Buy
CS-0145639 5mg $217 Buy
CS-0145639 10mg $347 Buy
CS-0145639 25mg $624 Buy

1H-Indole-2-carboxamide, 6-fluoro-N-[6-[4-(1-methylethyl)-4H-1,2,4-triazol-3-yl]-2-pyridinyl]- Chemical Properties, Uses, Production

Uses

ASK1-IN-2 is a potent and orally active inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with an IC50 of 32.8 nM. ASK1-IN-2 can be used for the research of ulcerative colitis[1].

in vivo

ASK1-IN-2 (25 mg/kg; p.o. daily for 7 d) improves dextran sulphate sodium (DSS)-induced ulcerative colitis (UC) in mice[1].
ASK1-IN-2 (25 mg/kg; p.o. daily for 7 d) blocks ASK1-p38/JNK signaling pathways and reduces inflammatory cytokine levels in DSS-induced mouse colon tissues[1].
ASK1-IN-2 (1 mg/kg; i.v.) shows low clearance (CL=1.38 L/h/kg) and moderate half-life (T1/2=1.45 h) in rats[1].
ASK1-IN-2 (10 mg/kg; p.o.) shows high oral exposure (AUClast=4517 hng/mL), 62.2% oral bioavailability and acceptable terminal half-life (T1/2=2.31 h) in rats[1].

Animal Model:Male ICR mice (18-22 g, 6-8 weeks) were given 3% DSS (w/v) orally in drinking water[1]
Dosage:25 mg/kg
Administration:P.o. daily for 7 days
Result:Induced a significant recovery of body weight loss, with an increase of +11.2%.
Decreased the disease activity index (DAI) score about a 2 unit.
Significantly prevented colon shortening.
Attenuated a severe colonic tissue damage and infiltration of inflammatory cells.
Animal Model:Male SD rats [1]
Dosage:1 mg/kg for i.v.; 10 mg/kg for p.o. (Pharmacokinetic Analysis)
Administration:I.v. and p.o. administration
Result:I.v.: CL=1.38 L/h/kg; T1/2=1.45 h.
P.o.: AUClast=4517 hng/mL; F=62.2%; T1/2=2.31 h.

IC 50

ASK1: 32.8 nM (IC50)

References

[1] Hou S, et, al. Structure-based discovery of 1H-indole-2-carboxamide derivatives as potent ASK1 inhibitors for potential treatment of ulcerative colitis. Eur J Med Chem. 2020 Dec 24;211:113114. DOI:10.1016/j.ejmech.2020.113114

1H-Indole-2-carboxamide, 6-fluoro-N-[6-[4-(1-methylethyl)-4H-1,2,4-triazol-3-yl]-2-pyridinyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

1H-Indole-2-carboxamide, 6-fluoro-N-[6-[4-(1-methylethyl)-4H-1,2,4-triazol-3-yl]-2-pyridinyl]- Suppliers

Global Suppliers ( 24)
Supplier Tel Email Country ProdList Advantage
Zhengzhou HSH Science & Technology Co., Ltd. 0371-55932928 18937192232; 1282296214@qq.com China 497 55
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4859 55
Shanghai Beckham Medical Technology Co., Ltd 13816613772 huahero21@sina.com China 2996 55
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
ShangHai Biochempartner Co.,Ltd 177-54423994 17754423994 2853530910@QQ.com China 8000 62
Shanghai Chaolan Chemical Technology Center QQ：65489617 13301690235 Sales@ATKchemical.com China 9699 58
BOC Sciences 16314854226; +8616314854226 inquiry@bocsci.com United States 19852 58
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
Shandong Jirun Biomedical Technology Co., Ltd. 0539-0539-8613587 17661611089 2639273505@qq.com China 237 58
Bide Pharmatech Ltd. 400-1647117 13681763483 product02@bidepharm.com China 59929 58
Supplier Advantage
Zhengzhou HSH Science & Technology Co., Ltd. 55
Shanghai Lollane Biological Technology Co.,Ltd. 55
Shanghai Beckham Medical Technology Co., Ltd 55
Shanghai YuanYe Biotechnology Co., Ltd. 60
ShangHai Biochempartner Co.,Ltd 62
Shanghai Chaolan Chemical Technology Center 58
BOC Sciences 58
TargetMol Chemicals Inc. 58
Shandong Jirun Biomedical Technology Co., Ltd. 58
Bide Pharmatech Ltd. 58

View Latest Price from 1H-Indole-2-carboxamide, 6-fluoro-N-[6-[4-(1-methylethyl)-4H-1,2,4-triazol-3-yl]-2-pyridinyl]- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
ASK1-IN-2 pictures 2026-07-27 ASK1-IN-2
2541792-70-3
 $68.00-263.00 99.36% 10g TargetMol Chemicals Inc.
  • ASK1-IN-2 pictures
  • ASK1-IN-2
    2541792-70-3
  • $68.00-263.00
  • 99.36%
  • TargetMol Chemicals Inc.

1H-Indole-2-carboxamide, 6-fluoro-N-[6-[4-(1-methylethyl)-4H-1,2,4-triazol-3-yl]-2-pyridinyl]- Spectrum

1H-Indole-2-carboxamide, 6-fluoro-N-[6-[4-(1-methylethyl)-4H-1,2,4-triazol-3-yl]-2-pyridinyl]-(2541792-70-3)1HNMR

2541792-70-3 (1H-Indole-2-carboxamide, 6-fluoro-N-[6-[4-(1-methylethyl)-4H-1,2,4-triazol-3-yl]-2-pyridinyl]-) Related Search:

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1H-Indole-2-carboxamide, 6-fluoro-N-[6-[4-(1-methylethyl)-4H-1,2,4-triazol-3-yl]-2-pyridinyl]- 6-fluoro-N-(6-(4-isopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-1H-indole-2-carboxamide ASK1-IN-2 colitis,ulcerative,signal-regulating,ASK1 IN 2,ASK1IN2,inhibit,MAP kinase kinase kinase, MEKK, MAPKKK,Apoptosis,ASK1,Inhibitor,ASK-1-IN-2,MAP3K ASK1-IN-2, 10 mM in DMSO 2541792-70-3