Urea, N-(3,4-dichlorophenyl)-N'-[3-[(4-quinazolinylamino)methyl]phenyl]-
![Urea, N-(3,4-dichlorophenyl)-N'-[3-[(4-quinazolinylamino)methyl]phenyl]- Structure](CAS/20210305/GIF/1648546-79-5.gif)
- CAS No.
- 1648546-79-5
- Chemical Name:
- Urea, N-(3,4-dichlorophenyl)-N'-[3-[(4-quinazolinylamino)methyl]phenyl]-
- Synonyms
- CAY10773;CAY-10773,CAY10773;Anticancer agent 251;N-(3,4-dichlorophenyl)-N′-[3-[(4-quinazolinylamino)methyl]phenyl]-urea;Urea, N-(3,4-dichlorophenyl)-N'-[3-[(4-quinazolinylamino)methyl]phenyl]-
- CBNumber:
- CB28433343
- Molecular Formula:
- C22H17Cl2N5O
- Molecular Weight:
- 438.31
- MDL Number:
- MOL File:
- 1648546-79-5.mol
- MSDS File:
- SDS
Urea, N-(3,4-dichlorophenyl)-N'-[3-[(4-quinazolinylamino)methyl]phenyl]- price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 31806 | CAY10773 ≥98% | 1648546-79-5 | 1mg | $75 | 2026-04-30 | Buy |
| Cayman Chemical | 31806 | CAY10773 ≥98% | 1648546-79-5 | 5mg | $278 | 2026-04-30 | Buy |
| Cayman Chemical | 31806 | CAY10773 ≥98% | 1648546-79-5 | 10mg | $516 | 2026-04-30 | Buy |
| ChemScene | CS-0182853 | Anticancer agent 251 | 1648546-79-5 | 1mg | $233 | 2026-06-04 | Buy |
| ChemScene | CS-0182853 | Anticancer agent 251 | 1648546-79-5 | 5mg | $699 | 2026-06-04 | Buy |
Urea, N-(3,4-dichlorophenyl)-N'-[3-[(4-quinazolinylamino)methyl]phenyl]- Chemical Properties, Uses, Production
Uses
Anticancer agent 251 (compound 7j) can induce cell death of bladder cancer cell T24 by inducing apoptosis, autophagy or ferroptosis[1].
Biological Activity
CAY10773 is a derivative of the ferroptosis inducer sorafenib .1 It selectively inhibits proliferation of BEL-7402, MGC803, and T24 bladder cancer cells (IC50s = 5.77, 5.21 and 3.97 μM, respectively) over non-cancerous HCV-29 cells (IC50 = 23.19 μM). CAY10773 induces apoptosis in T24 cells when used at concentrations ranging from 2 to 6 μM but induces ferroptosis at concentrations greater than or equal to 6 μM with 10 hour or longer incubation times. It increases the production of reactive oxygen species (ROS) and decreases the mitochondrial membrane potential in T24 cells. CAY10773 (≥6 μM) also induces autophagy with incubation times longer than eight hours.
References
1.Chen, J.-N., Li, T., Cheng, L., et al.Synthesis and in vitro anti-bladder cancer activity evaluation of quinazolinyl-arylurea derivativesEur. J. Med. Chem.205112661(2020)
Urea, N-(3,4-dichlorophenyl)-N'-[3-[(4-quinazolinylamino)methyl]phenyl]- Preparation Products And Raw materials
Raw materials
Preparation Products
Urea, N-(3,4-dichlorophenyl)-N'-[3-[(4-quinazolinylamino)methyl]phenyl]- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Jinan Jiuli Biotechnology Co. , Ltd. | 15865264761 | 486064515@qq.com | China | 5000 | 58 |
| ChemeGen | 18818260767 | 2625930290@qq.com | China | 6966 | 58 |
| Beijing Biocreative Technology Co., Ltd. | 15522676233 | 3007606172@qq.com | China | 1246 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Shanghai Yiyan Biotechnology Co. , Ltd. | 021-69985186 13611928337 | 3427709316@qq.com | China | 7982 | 58 |
