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ChemicalBook >> CAS DataBase List >>6,6'-Ureylene-bis(1-naphthol-3-sulfonic acid)

6,6'-Ureylene-bis(1-naphthol-3-sulfonic acid)

6,6'-Ureylene-bis(1-naphthol-3-sulfonic acid) Structure
6,6'-Ureylene-bis(1-naphthol-3-sulfonic acid) structure
CAS No.
134-47-4
Chemical Name:
6,6'-Ureylene-bis(1-naphthol-3-sulfonic acid)
Synonyms
H)-dione;phosgenated;Urea J Acid;-bicarbazole;AMI-1,freeacid;-tetrasulfonic Acid;J ACID UREA, FREE ACID;Scarletacidlowsodiumsalt;-Tetrabromo bisphenol a 99+%;-Methylenebis-1,3-benzodioxol-5-ol
CBNumber:
CB2855268
Molecular Formula:
C21H16N2O9S2
Molecular Weight:
504.49
MDL Number:
MFCD00035715
MOL File:
134-47-4.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 00:50:26
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6,6'-Ureylene-bis(1-naphthol-3-sulfonic acid) Properties

Density 1.798±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
solubility DMSO: 83.33 mg/mL (165.18 mM)
pka -0.17±0.40(Predicted)
form Solid
color Light brown to brown
CAS DataBase Reference 134-47-4(CAS DataBase Reference)
FDA UNII 2QJN9485J7
EPA Substance Registry System 7,7'-(Carbonyldiimino)bis[4-hydroxy-2-naphthalenesulfonic acid] (134-47-4)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Health Hazard (GHS08)
GHS08
Signal word  Warning
Hazard statements  H334
Precautionary statements  P261-P285-P304+P341-P342+P311-P403-P501c
TSCA  TSCA listed
REACH Registrations Active

6,6'-Ureylene-bis(1-naphthol-3-sulfonic acid) price More Price(57)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Usbiological 289419 Scarlet acid Asreported 134-47-4 1g $388 2026-06-03 Buy
Usbiological 289419 Scarlet acid Asreported 134-47-4 2g $591 2026-06-03 Buy
Usbiological 289419 Scarlet acid Asreported 134-47-4 5g $832 2026-06-03 Buy
ChemScene CS-0010165 AMI-1 free acid 99.53% 134-47-4 5mg $27 2026-06-04 Buy
ChemScene CS-0010165 AMI-1 free acid 99.53% 134-47-4 10mg $32 2026-06-04 Buy
Product number Packaging Price Buy
289419 1g $388 Buy
289419 2g $591 Buy
289419 5g $832 Buy
CS-0010165 5mg $27 Buy
CS-0010165 10mg $32 Buy

6,6'-Ureylene-bis(1-naphthol-3-sulfonic acid) Chemical Properties, Uses, Production

Uses

7,7''-(Carbonylbis(azanediyl))bis(4-hydroxynaphthalene-2-sulfonic acid) (cas# 134-47-4) is a pharmacologically active compound capable of selective nonbisphosphonate inhibition of human geranylgeranyl diphosphate synthase, and inhibition of shikimate dehydrogenase and shikimate kinase in shikimate pathway of Helicobacter pylori.

Preparation

7,7' -Urylenebis(4-hydroxynaphthalene-2- sulfonic acid) [134-47-4] , J acid urea, carbonyl J acid, is produced by reacting the sodium salt of J acid with phosgene in aqueous solution at 30℃ and maintaining alkalinity with sodium carbonate. After being heated to 80℃, the product is salted out with sodium chloride (yield ca. 100 %). It is used to produce C.I. Direct Orange 26; C.I. Direct Reds 4, 14, 23, and 80; and C.I. Direct Brown 112.

in vivo

AMI-1 free acid (0.5 mg; intratumorally; daily; for 7 days) inhibits S180 viability in vivo[4].
AMI-1 free acid (0.5 mg; intratumorally; daily; for 7 days) downregulates PRMT5 but does not regulate the expression of PRMT7 in a tumor xenograft model[4].
AMI-1 free acid (0.5 mg; intratumorally; daily; for 7 days) decreases the levels of H4R3me2s and H3R8me2s in a tumor xenograft model[4].

Animal Model:6-7 weeks old male Kunming mice (18-22 g), with S180 cells xenograft[4]
Dosage:0.5 mg
Administration:Intratumorally, daily, for 7 days
Result:Decreased tumor weight.

6,6'-Ureylene-bis(1-naphthol-3-sulfonic acid) Preparation Products And Raw materials

Raw materials

Sodium bisulfite Sodium metabisulfite

Preparation Products

trisodium [mu-[2-[[1-hydroxy-6-[[[[5-hydroxy-6-[(2-hydroxy-5-sulphophenyl)azo]-7-sulpho-2-naphthyl]amino]carbonyl]amino]-3-sulpho-2-naphthyl]azo]benzoato(7-)]]dicuprate(3-) Direct Red 23 Direct Orange S Leather Black Copper, 2,2'-[carbonylbis[imino(1-hydroxy-3-sulfo-6,2-naphthalenediyl)azo]]bis[benzoic acid] complex
tetrasodium [mu-[[7,7'-(carbonyldiimino)bis[4-hydroxy-3-[(2-hydroxy-5-sulphophenyl)azo]naphthalene-2-sulphonato]](8-)]]dicuprate(4-) DIRECT ORANGE 118 DIRECT RED 26 7,7'-(Carbonyldiimino)bis[4-hydroxy-3-[(2-hydroxy-5-nitrophenyl)azo]-2-naphthalenesulfonic acid]disodium salt DIRECT ORANGE 26
DIRECT RED 4 trisodium [mu-[2-[[1-hydroxy-6-[[[[5-hydroxy-6-[(2-hydroxy-5-sulphophenyl)azo]-7-sulpho-2-naphthyl]amino]carbonyl]amino]-3-sulpho-2-naphthyl]azo]benzoato(7-)]]dicuprate(3-) Direct Violet 89 Direct red 72 C.I. Direct Red 36, tetrasodium salt
Direct Red 264 DIRECT RED 80 Direct red 194 (C.I. 35785) 7,7'-[Ureylenebis[(1-hydroxy-3-sodiosulfonaphthalene-6,2-diyl)azo(4,1-phenylene)azo]]bis[naphthalene-1,3-disulfonic acid disodium] salt Direct Red 23

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6,6'-Ureylene-bis(1-naphthol-3-sulfonic acid) Suppliers

Global Suppliers ( 136)
Supplier Tel Email Country ProdList Advantage
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
TAIYUAN RHF CO.,LTD. +86 351 7031519 sales@RHFChem.com China 2334 56
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Syntechem Co.,Ltd info@syntechem.com China 12973 57
China Langchem Inc. 0086-21-58956006 China 7798 57
Shanghai Sunway Pharmaceutical Technology Co., Ltd 13761987713 hxzheng@sunwaypharm.cn China 8663 57
BOC Sciences 1-631-485-4226; 16314854226 info@bocsci.com United States 9920 65
Quzhou Juhua Friendship Co., Ltd 0570-3066667 China 3922 58
Hubei Jusheng Technology Co.,Ltd 027-59599241 18871490274 1400878000@qq.com China 9506 58
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
Supplier Advantage
3B Pharmachem (Wuhan) International Co.,Ltd. 69
TAIYUAN RHF CO.,LTD. 56
Shanghai Hanhong Scientific Co.,Ltd. 64
Syntechem Co.,Ltd 57
China Langchem Inc. 57
Shanghai Sunway Pharmaceutical Technology Co., Ltd 57
BOC Sciences 65
Quzhou Juhua Friendship Co., Ltd 58
Hubei Jusheng Technology Co.,Ltd 58
Shanghai YuanYe Biotechnology Co., Ltd. 60

View Latest Price from 6,6'-Ureylene-bis(1-naphthol-3-sulfonic acid) manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
6,6'-Ureylene-bis(1-naphthol-3-sulfonic acid) pictures 2026-08-25 6,6'-Ureylene-bis(1-naphthol-3-sulfonic acid)
134-47-4
 $2.00-5.00 1kg 99% 100kg ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Scarlet acid pictures 2025-06-27 Scarlet acid
134-47-4
 1KG 99% 500000kg Hebei Chuanghai Biotechnology Co., Ltd
Scarlet acid pictures 2025-06-20 Scarlet acid
134-47-4
 $9.00-60.00 1kg 0.99 25 tons Hebei Yanxi Chemical Co., Ltd.
  • Scarlet acid pictures
  • Scarlet acid
    134-47-4
  • $0.00
  • 99%
  • Hebei Chuanghai Biotechnology Co., Ltd
  • Scarlet acid pictures
  • Scarlet acid
    134-47-4
  • $9.00-60.00
  • 0.99
  • Hebei Yanxi Chemical Co., Ltd.

6,6'-Ureylene-bis(1-naphthol-3-sulfonic acid) Spectrum

6,6'-Ureylene-bis(1-naphthol-3-sulfonic acid)(134-47-4)1HNMR

134-47-4 (6,6'-Ureylene-bis(1-naphthol-3-sulfonic acid)) Related Search:

Imidazolidinyl urea Dodecylbenzenesulphonic acid Molasses Solvent Red 43 Naphthalene
Linear alkyl benzenesulphonate Sodium N-cyclohexylsulfamate Chlorophosphonazo III 1-Dodecanesulfonic acid sodium salt Calcium dodecylbenzene sulfonate
Disodium 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate) DIRECT RED 80 CALCOMINE ORANGE 2RS Direct Red 23 Linear alkylbenzene sulphonic acid
DIRECT RED 83 DIRECT ORANGE 26 sulfonaphthol

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4,4'-dihydroxy-7,7'-ureylenedi(naphthalene-2-sulphonic acid) 7,7'-(Carbonyldiimino)bis[4-hydroxy-2-naphthalenesulfonic acid] 6,6'-ureylene-bis(1-naphthol-3-sulfonic acid) phosgenated N,N'-bis(4-hydroxy-2-sulfonaphthalene-7-yl)urea 7,7'-Ureylenebis(4-hydroxy-2-naphthalenesulfonic acid) N,N'-Bis[6-(1-naphthol-3-sulfonic acid)]urea 6,6'-ureylenbis-1-naphthol-3-sulfonic acid 7,7'-(Carbonylbisimino)bis(4-hydroxynaphthalene-2-sulfonic acid) 4-hydroxy-7-[(5-hydroxy-7-sulfo-2-naphthyl)carbamoylamino]naphthalene-2-sulfonic acid 4-hydroxy-7-[(5-hydroxy-7-sulfo-naphthalen-2-yl)carbamoylamino]naphthalene-2-sulfonic acid 4-hydroxy-7-[(5-hydroxy-7-sulfonaphthalen-2-yl)carbamoylamino]naphthalene-2-sulfonic acid 7,7'-(Carbonylbis(azanediyl))bis(4-hydroxynaphthalene-2-sulfonic acid) 2-Naphthalenesulfonic acid, 7,7-(carbonyldiimino)bis4-hydroxy- J ACID UREA, FREE ACID 66UREYLENEBIS1NAPHTHOL3SULPHONICACIDDISODIUMSALT 7,7'-(carbonyldiimino)bis[4-hydroxy-2-naphthalenesulfonic aci AMI-1,freeacid -Ureylene-bis(1-naphthol-3-sulfonic acid) -(Iminosulfonyloxy)bis[6-deoxy-1,2:3,4-bis-O-(1-methylethylidene)-&alpha -Tetrakis(methoxymethoxy)-indigotin -diyl)bis(oxy))bis(3,5-diiodo-4,1-phenylene))bis(2-aminopropanoic Acid) -Oxybis(4,6-dihydro-2H-furo[3,2-c]pyran-2-one) H)-dione -Tetrakis(methoxymethoxy)-indigotin N-Isopropyl -((1s,3s,5r,7r)-Adamantane-1,3-diylbis(4-methoxy-3,1-phenylene))bis(2-naphthoic Acid Diethyl Ester -Trehalose Dimycolate (Cord-Factor, TDM) -Tetrabromo bisphenol a 99+% -Methylenebis-1,3-benzodioxol-5-ol -bicarbazole -tetrasulfonic Acid 6,6'-Ureylene-bis(1-naphthol-3-sulfonic acid) ISO 9001：2015 REACH Urea J Acid 4,4'-dihydroxy-7,7'-ureylenedi(naphthalene-2-sulphonic acid 5,5-Dihydroxy-2,2-Dinaphthyl Urea-7,7 Disulfonic Acid Scarletacidlowsodiumsalt 134-47-4 134-47-7 C21H16N2O9S2 Intermediates of Dyes and Pigments