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6,6'-Ureylene-bis(1-naphthol-3-sulfonic acid)

6,6'-Ureylene-bis(1-naphthol-3-sulfonic acid) structure

CAS No.: 134-47-4

Chemical Name:: 6,6'-Ureylene-bis(1-naphthol-3-sulfonic acid)

Synonyms: H)-dione;phosgenated;Urea J Acid;-bicarbazole;AMI-1,freeacid;-tetrasulfonic Acid;J ACID UREA, FREE ACID;Scarletacidlowsodiumsalt;-Tetrabromo bisphenol a 99+%;-Methylenebis-1,3-benzodioxol-5-ol

CBNumber:: CB2855268

Molecular Formula:: C21H16N2O9S2

Molecular Weight:: 504.49

MDL Number:: MFCD00035715

MOL File:: 134-47-4.mol

Last updated:2025-06-18 14:25:26

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6,6'-Ureylene-bis(1-naphthol-3-sulfonic acid) Properties

Density	1.798±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
solubility	DMSO: 83.33 mg/mL (165.18 mM)
pka	-0.17±0.40(Predicted)
form	Solid
color	Light brown to brown
CAS DataBase Reference	134-47-4(CAS DataBase Reference)
FDA UNII	2QJN9485J7
EPA Substance Registry System	7,7'-(Carbonyldiimino)bis[4-hydroxy-2-naphthalenesulfonic acid] (134-47-4)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS08
Signal word	Warning
Hazard statements	H334
Precautionary statements	P261-P285-P304+P341-P342+P311-P403-P501c

6,6'-Ureylene-bis(1-naphthol-3-sulfonic acid) price More Price(28)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	C177258	7,7''-(Carbonylbis(azanediyl))bis(4-hydroxynaphthalene-2-sulfonicacid)	134-47-4	500mg	$75	2021-12-16	Buy
Usbiological	162198	6,6'-	134-47-4	10mg	$460	2021-12-16	Buy
American Custom Chemicals Corporation	CHM0077681	6,6'-UREYLENE-BIS(1-NAPHTHOL-3-SULFONIC ACID) 95.00%	134-47-4	1G	$704.55	2021-12-16	Buy
American Custom Chemicals Corporation	CHM0077681	6,6'-UREYLENE-BIS(1-NAPHTHOL-3-SULFONIC ACID) 95.00%	134-47-4	5G	$1081.08	2021-12-16	Buy
Matrix Scientific	076104	7,7'-(Carbonylbis(azanediyl))bis(4-hydroxynaphthalene-2-sulfonic acid) 95+%	134-47-4	1g	$116	2021-12-16	Buy

Product number	Packaging	Price	Buy
C177258	500mg	$75	Buy
162198	10mg	$460	Buy
CHM0077681	1G	$704.55	Buy
CHM0077681	5G	$1081.08	Buy
076104	1g	$116	Buy

6,6'-Ureylene-bis(1-naphthol-3-sulfonic acid) Chemical Properties,Uses,Production

Uses

7,7''-(Carbonylbis(azanediyl))bis(4-hydroxynaphthalene-2-sulfonic acid) (cas# 134-47-4) is a pharmacologically active compound capable of selective nonbisphosphonate inhibition of human geranylgeranyl diphosphate synthase, and inhibition of shikimate dehydrogenase and shikimate kinase in shikimate pathway of Helicobacter pylori.

Preparation

7,7' -Urylenebis(4-hydroxynaphthalene-2- sulfonic acid) [134-47-4] , J acid urea, carbonyl J acid, is produced by reacting the sodium salt of J acid with phosgene in aqueous solution at 30℃ and maintaining alkalinity with sodium carbonate. After being heated to 80℃, the product is salted out with sodium chloride (yield ca. 100 %). It is used to produce C.I. Direct Orange 26; C.I. Direct Reds 4, 14, 23, and 80; and C.I. Direct Brown 112.

in vivo

AMI-1 free acid (0.5 mg; intratumorally; daily; for 7 days) inhibits S180 viability in vivo^[4].
AMI-1 free acid (0.5 mg; intratumorally; daily; for 7 days) downregulates PRMT5 but does not regulate the expression of PRMT7 in a tumor xenograft model^[4].
AMI-1 free acid (0.5 mg; intratumorally; daily; for 7 days) decreases the levels of H4R3me2s and H3R8me2s in a tumor xenograft model^[4].

Animal Model:	6-7 weeks old male Kunming mice (18-22 g), with S180 cells xenograft^[4]
Dosage:	0.5 mg
Administration:	Intratumorally, daily, for 7 days
Result:	Decreased tumor weight.

6,6'-Ureylene-bis(1-naphthol-3-sulfonic acid) Preparation Products And Raw materials

Raw materials

Sodium bisulfite Sodium metabisulfite

Preparation Products

trisodium [mu-[2-[[1-hydroxy-6-[[[[5-hydroxy-6-[(2-hydroxy-5-sulphophenyl)azo]-7-sulpho-2-naphthyl]amino]carbonyl]amino]-3-sulpho-2-naphthyl]azo]benzoato(7-)]]dicuprate(3-) Direct Red 23 Direct Orange S Leather Black Copper, 2,2'-[carbonylbis[imino(1-hydroxy-3-sulfo-6,2-naphthalenediyl)azo]]bis[benzoic acid] complex

tetrasodium [mu-[[7,7'-(carbonyldiimino)bis[4-hydroxy-3-[(2-hydroxy-5-sulphophenyl)azo]naphthalene-2-sulphonato]](8-)]]dicuprate(4-) DIRECT ORANGE 118 DIRECT RED 26 7,7'-(Carbonyldiimino)bis[4-hydroxy-3-[(2-hydroxy-5-nitrophenyl)azo]-2-naphthalenesulfonic acid]disodium salt DIRECT ORANGE 26

DIRECT RED 4 trisodium [mu-[2-[[1-hydroxy-6-[[[[5-hydroxy-6-[(2-hydroxy-5-sulphophenyl)azo]-7-sulpho-2-naphthyl]amino]carbonyl]amino]-3-sulpho-2-naphthyl]azo]benzoato(7-)]]dicuprate(3-) Direct Violet 89 Direct red 72 C.I. Direct Red 36, tetrasodium salt

Direct Red 264 DIRECT RED 80 Direct red 194 (C.I. 35785) 7,7'-[Ureylenebis[(1-hydroxy-3-sodiosulfonaphthalene-6,2-diyl)azo(4,1-phenylene)azo]]bis[naphthalene-1,3-disulfonic acid disodium] salt Direct Red 23

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6,6'-Ureylene-bis(1-naphthol-3-sulfonic acid) Suppliers

Global( 136)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Yanxi Chemical Co., Ltd.	+8618531123677	faithe@yan-xi.com	China	5853	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615531151365	mina@chuanghaibio.com	China	18126	58
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD	+86-13017695106 +86-13676922317	jiuyitime@fdachem.com	China	9029	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28172	58
Xiamen AmoyChem Co., Ltd	+86-86-5926051114 +8615060885618	sales@amoychem.com	China	6369	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29800	58
SIMAGCHEM CORP	+86-5922680277 +86-13806087780	sale@simagchem.com	China	17346	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34563	58

Supplier	Advantage
Hebei Yanxi Chemical Co., Ltd.	58
Hebei Chuanghai Biotechnology Co., Ltd	58
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD	58
Hubei Jusheng Technology Co.,Ltd.	58
Xiamen AmoyChem Co., Ltd	58
Hubei xin bonus chemical co. LTD	58
Alchem Pharmtech,Inc.	58
career henan chemical co	58
SIMAGCHEM CORP	58
Hefei TNJ Chemical Industry Co.,Ltd.	58

View Lastest Price from 6,6'-Ureylene-bis(1-naphthol-3-sulfonic acid) manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-06-27	Scarlet acid 134-47-4	US $0.00 / KG	1KG	99%	500000kg	Hebei Chuanghai Biotechnology Co., Ltd
2025-06-20	Scarlet acid 134-47-4	US $60.00-9.00 / kg	1kg	0.99	25 tons	Hebei Yanxi Chemical Co., Ltd.
2025-06-18	6,6'-Ureylene-bis(1-naphthol-3-sulfonic acid) 134-47-4	US $2.00-5.00 / kg	1kg	99%	100kg	ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Scarlet acid
134-47-4
US $0.00 / KG
99%
Hebei Chuanghai Biotechnology Co., Ltd

Scarlet acid
134-47-4
US $60.00-9.00 / kg
0.99
Hebei Yanxi Chemical Co., Ltd.

6,6'-Ureylene-bis(1-naphthol-3-sulfonic acid)
134-47-4
US $2.00-5.00 / kg
99%
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

134-47-4(6,6'-Ureylene-bis(1-naphthol-3-sulfonic acid))Related Search:

Imidazolidinyl urea CALCIUM DODECYLBENZENE SULFONATE Dodecylbenzenesulphonic acid Molasses CHLOROPHOSPHONAZO III

Linear alkyl benzenesulphonate 1-DODECANESULFONIC ACID SODIUM SALT Naphthalene Solvent Red 43 Sodium N-cyclohexylsulfamate

Disodium 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate) LINEAR ALKYLBENZENE SULPHONIC ACID DIRECT RED 80 CALCOMINE ORANGE 2RS Direct Red 23

DIRECT RED 83 DIRECT ORANGE 26 6,6'-Ureylene-bis(1-naphthol-3-sulfonic acid)

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4,4'-dihydroxy-7,7'-ureylenedi(naphthalene-2-sulphonic acid) 7,7'-(Carbonyldiimino)bis[4-hydroxy-2-naphthalenesulfonic acid] 6,6'-ureylene-bis(1-naphthol-3-sulfonic acid) phosgenated N,N'-bis(4-hydroxy-2-sulfonaphthalene-7-yl)urea 7,7'-Ureylenebis(4-hydroxy-2-naphthalenesulfonic acid) N,N'-Bis[6-(1-naphthol-3-sulfonic acid)]urea 6,6'-ureylenbis-1-naphthol-3-sulfonic acid 7,7'-(Carbonylbisimino)bis(4-hydroxynaphthalene-2-sulfonic acid) 4-hydroxy-7-[(5-hydroxy-7-sulfo-2-naphthyl)carbamoylamino]naphthalene-2-sulfonic acid 4-hydroxy-7-[(5-hydroxy-7-sulfo-naphthalen-2-yl)carbamoylamino]naphthalene-2-sulfonic acid 4-hydroxy-7-[(5-hydroxy-7-sulfonaphthalen-2-yl)carbamoylamino]naphthalene-2-sulfonic acid 7,7'-(Carbonylbis(azanediyl))bis(4-hydroxynaphthalene-2-sulfonic acid) 2-Naphthalenesulfonic acid, 7,7-(carbonyldiimino)bis4-hydroxy- J ACID UREA, FREE ACID 66UREYLENEBIS1NAPHTHOL3SULPHONICACIDDISODIUMSALT 7,7'-(carbonyldiimino)bis[4-hydroxy-2-naphthalenesulfonic aci AMI-1,freeacid -Ureylene-bis(1-naphthol-3-sulfonic acid) -(Iminosulfonyloxy)bis[6-deoxy-1,2:3,4-bis-O-(1-methylethylidene)-&alpha -Tetrakis(methoxymethoxy)-indigotin -diyl)bis(oxy))bis(3,5-diiodo-4,1-phenylene))bis(2-aminopropanoic Acid) -Oxybis(4,6-dihydro-2H-furo[3,2-c]pyran-2-one) H)-dione -Tetrakis(methoxymethoxy)-indigotin N-Isopropyl -((1s,3s,5r,7r)-Adamantane-1,3-diylbis(4-methoxy-3,1-phenylene))bis(2-naphthoic Acid Diethyl Ester -Trehalose Dimycolate (Cord-Factor, TDM) -Tetrabromo bisphenol a 99+% -Methylenebis-1,3-benzodioxol-5-ol -bicarbazole -tetrasulfonic Acid 6,6'-Ureylene-bis(1-naphthol-3-sulfonic acid) ISO 9001：2015 REACH Urea J Acid 4,4'-dihydroxy-7,7'-ureylenedi(naphthalene-2-sulphonic acid 5,5-Dihydroxy-2,2-Dinaphthyl Urea-7,7 Disulfonic Acid Scarletacidlowsodiumsalt 134-47-4 134-47-7 C21H16N2O9S2 Intermediates of Dyes and Pigments