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ChemicalBook >> CAS DataBase List >>Disodium 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate)

Disodium 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate)

Disodium 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate) Structure
Disodium 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate) structure
CAS No.
20324-87-2
Chemical Name:
Disodium 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate)
Synonyms
AMI-1;AMI 1;AMI1;AMI-1 disodium salt;AMI-1, 10 mM in DMSO;AMI-1 - AMI-1 sodium salt;J acid urea,disodiuM salt 70%;Disodium 6,6'-ureylenebis[1-naphthol-3-sulfonate];AMI 1, protein arginine methyltransferase inhibitor;Sodium 6,6'-(1,3-ureylene) bis(1-naphthol-3-sulfonate);SODIUM 6,6'-(1,3-UREYLENE) BIS(1,1'-NAPHTHOL)-3,3'-SULFONATE;Dinatrium-7,7'-(carbonyldiimino)bis(4-hydroxynaphthalin-2-sulfonat)
CBNumber:
CB3855058
Molecular Formula:
C21H17N2NaO9S2
Molecular Weight:
528.48
MDL Number:
MFCD00068249
MOL File:
20324-87-2.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-16 07:06:08
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Disodium 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate) Properties

storage temp. under inert gas (nitrogen or Argon) at 2-8°C
solubility insoluble in EtOH; insoluble in DMSO; ≥19.1 mg/mL in H2O
form Brown solid.
color Light brown to brown
EPA Substance Registry System 2-Naphthalenesulfonic acid, 7,7'-(carbonyldiimino)bis[4-hydroxy-, disodium salt (20324-87-2)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P301+P312-P302+P352-P304+P340-P305+P351+P338
TSCA  TSCA listed
REACH Registrations Active

Disodium 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate) price More Price(53)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-5013 AMI-1 98.0% 20324-87-2 10mg $32 2026-06-04 Buy
ChemScene CS-5013 AMI-1 98.0% 20324-87-2 25mg $54 2026-06-04 Buy
ChemScene CS-5013 AMI-1 98.0% 20324-87-2 50mg $92 2026-06-04 Buy
ChemScene CS-5013 AMI-1 98.0% 20324-87-2 100mg $157 2026-06-04 Buy
Matrix Scientific 304486 Sodium 7,7'-(carbonylbis(azanediyl))bis(4-hydroxynaphthalene-2-sulfonate) 20324-87-2 50.00mg $71 2026-05-19 Buy
Product number Packaging Price Buy
CS-5013 10mg $32 Buy
CS-5013 25mg $54 Buy
CS-5013 50mg $92 Buy
CS-5013 100mg $157 Buy
304486 50.00mg $71 Buy

Disodium 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate) Chemical Properties, Uses, Production

Chemical Properties

Light grey paste. Soluble in water and easily soluble in alkaline solution.

Uses

AMI-1 is a Histone Methyltransferase (HMT) inhibitor.

Biological Activity

potent, cell permeable and specific protein arginine n-methyltransferase 1 (prmt1) inhibitor (ic50 = 8, 8 μm), does not compete for the adomet (s-adenosyl-l-methionine, sam) binding site, blocks peptide substrate binding, hiv-1 rt polymerase inhibitor (ic50 = 5, 0 μm).

in vivo

AMI-1 (0.5 mg; intratumorally; daily; for 7 days) inhibits S180 viability in vivo[4].
AMI-1 (0.5 mg; intratumorally; daily; for 7 days) downregulates PRMT5 but does not regulate the expression of PRMT7 in a tumor xenograft model[4].
AMI-1 (0.5 mg; intratumorally; daily; for 7 days) decreases the levels of H4R3me2s and H3R8me2s in a tumor xenograft model[4].

Animal Model:6-7 weeks old male Kunming mice (18-22 g), with S180 cells xenograft[4]
Dosage:0.5 mg
Administration:Intratumorally, daily, for 7 days
Result:Decreased tumor weight.

IC 50

PRMT1

Disodium 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate) Preparation Products And Raw materials

Raw materials

Preparation Products

Disodium 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate) Suppliers

Global Suppliers ( 137)
Supplier Tel Email Country ProdList Advantage
Shanghai Boyle Chemical Co., Ltd. sales@boylechem.com China 2915 55
Spectrum Chemical Manufacturing Corp. 021-021-021-67601398-809-809-809 15221380277 marketing_china@spectrumchemical.com China 9643 60
Dalian Meilun Biotech Co., Ltd. 0411-62910999 13889544652 sales@meilune.com China 4765 58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 025-66113011 13913916777 cfzhang@aikonchem.com China 19902 55
Haoyuan Chemexpress Co., Ltd. 021-58950125 info@chemexpress.com China 7545 61
MedChemexpress LLC 021-58955995 sales@medchemexpress.cn United States 4853 58
Nanjing Dulai Biotechnology Co., Ltd. 025-84699383-8003;025-846993838003-8003 18013301590 njduly@126.com China 3293 55
Quzhou Juhua Friendship Co., Ltd 0570-3066667 China 3922 58
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
D&C Chemicals +86-21-58447131 1724405207@qq.com China 470 55
Supplier Advantage
Shanghai Boyle Chemical Co., Ltd. 55
Spectrum Chemical Manufacturing Corp. 60
Dalian Meilun Biotech Co., Ltd. 58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 55
Haoyuan Chemexpress Co., Ltd. 61
MedChemexpress LLC 58
Nanjing Dulai Biotechnology Co., Ltd. 55
Quzhou Juhua Friendship Co., Ltd 58
Bide Pharmatech Ltd. 60
D&C Chemicals 55

View Latest Price from Disodium 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate) manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
AMI 1 pictures 2026-08-25 AMI 1
20324-87-2
 $2.00-5.00 1kg 99% 100kg ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
AMI-1 pictures 2026-07-15 AMI-1
20324-87-2
 $40.00-118.00 99.98% 10g TargetMol Chemicals Inc.
Disodium 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate) pictures 2020-01-09 Disodium 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate)
20324-87-2
 $3.00 1KG 98% 200KG Career Henan Chemical Co
  • AMI 1 pictures
  • AMI 1
    20324-87-2
  • $2.00-5.00
  • 99%
  • ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
  • AMI-1 pictures
  • AMI-1
    20324-87-2
  • $40.00-118.00
  • 99.98%
  • TargetMol Chemicals Inc.

Disodium 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate) Spectrum

Disodium 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate)(20324-87-2)1HNMR

20324-87-2 (Disodium 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate)) Related Search:

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Folic acid 8-Amino-1-naphthol-3,6-disulfonic acid monosodium salt monohydrate Trisodium citrate dihydrate Citric acid Chlorophosphonazo III
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1of4

4-hydroxy-7-[(5-hydroxy-7-sulfonatonaphthalen-2-yl)carbamoylamino]naphthalene-2-sulfonate AMI-1 - AMI-1 sodium salt AMI-1;AMI 1;AMI1 disodium 4-hydroxy-7-[(5-hydroxy-7-sulfonato-2-naphthyl)carbamoylamino]naphthalene-2-sulfonate disodium 4-hydroxy-7-[(5-hydroxy-7-sulfonato-naphthalen-2-yl)carbamoylamino]naphthalene-2-sulfonate disodium 4-hydroxy-7-[(5-hydroxy-7-sulfonatonaphthalen-2-yl)carbamoylamino]naphthalene-2-sulfonate J acid urea,disodiuM salt 70% 7,7'-(carbonyldiimino)bis(4-hydroxy-2-naphthalenesulfonic acid) disodium salt Disodium 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate) Sodium 6,6'-(1,3-ureylene) bis(1-naphthol-3-sulfonate) Disodium 6,6'-ureylenebis[1-naphthol-3-sulfonate] SODIUM 6,6'-(1,3-UREYLENE) BIS(1,1'-NAPHTHOL)-3,3'-SULFONATE AMI-1 disodium salt Dinatrium-7,7'-(carbonyldiimino)bis(4-hydroxynaphthalin-2-sulfonat) protein arginine N-methyltransferases,AMI 1,Hmt1p,Inhibitor,AMI-1,inhibit,PRMT1,yeast-Hmt1p,AMI1,Histone Methyltransferase,PRMTs Sodium 7,7'-(carbonylbis(azanediyl))bis(4-hydroxynaphthalene-2-sulfonate) Disodium 7,7'-(Carbonyldiimino)Bis(4-Hydroxynaphthalené-2-Sulphonate) AMI 1, protein arginine methyltransferase inhibitor AMI-1, 10 mM in DMSO 20324-87-2 C21H14N2Na2O9S2 C21H14O9N2S2Na2 C21H14N2O9S2Na2 Inhibitors