AES-350
- CAS No.
- 847249-57-4
- Chemical Name:
- AES-350
- Synonyms
- AES-350;4-(4-tert-butylbenzamido)-N-hydroxybenzamide;4-[[4-(1,1-dimethylethyl)benzoyl]amino]-N-hydroxy-benzamide;Benzamide, 4-[[4-(1,1-dimethylethyl)benzoyl]amino]-N-hydroxy-;Histone deacetylases,AES 350,MV4-11,AES-350,Apoptosis,acute myeloid leukemia,AML,Inhibitor,inhibit,AES350,HDAC
- CBNumber:
- CB28571007
- Molecular Formula:
- C18H20N2O3
- Molecular Weight:
- 312.36
- MDL Number:
- MFCD34180323
- MOL File:
- 847249-57-4.mol
- MSDS File:
- SDS
| Density | 1.218±0.06 g/cm3(Predicted) |
|---|---|
| storage temp. | 4°C, protect from light |
| solubility | DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml,Ethanol: 1 mg/ml |
| form | A crystalline solid |
| pka | 8.93±0.10(Predicted) |
| color | Off-white to light yellow |
| FDA UNII | 8ZGC21O8KI |
AES-350 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 30607 | AES-350 ≥98% | 847249-57-4 | 500μg | $174 | 2026-04-30 | Buy |
| Cayman Chemical | 30607 | AES-350 ≥98% | 847249-57-4 | 1mg | $268 | 2026-04-30 | Buy |
| Cayman Chemical | 30607 | AES-350 ≥98% | 847249-57-4 | 5mg | $667 | 2026-04-30 | Buy |
| Biosynth | XIB24957 | AES-350 | 847249-57-4 | 5mg | $1212.85 | 2026-06-05 | Buy |
| Biosynth | XIB24957 | AES-350 | 847249-57-4 | 10mg | $1687.4 | 2026-06-05 | Buy |
AES-350 Chemical Properties, Uses, Production
Uses
AES-350 is a potent and orally active HDAC6 inhibitor with an IC50 and a Ki of 0.0244 μM and 0.035 μM, respectively. AES-350 is also against HDAC3, HDAC8 in an enzymatic activity assay with IC50 values of 0.187 μM and 0.245 μM, respectively. AES-350 triggers apoptosis in AML cells through HDAC inhibition and can be used for acute myeloid leukemia (AML) research[1].
in vivo
AES-350 (oral gavage; 20 mg/kg; single dose) exhibits a relative good pharmacokinetic (PK) properties in CD-1 mice. The single dose oral bioavailability (F%) of 51 is 19.8%. In comparison, the reported F% for SAHA in mice is significantly lower (8%)[1].
IC 50
HDAC6: 24.4 nM (IC50); HDAC3: 187 nM (IC50); HDAC11: 245 nM (IC50)
References
[1] Andrew E Shouksmith, et al. Class I/IIb-Selective HDAC Inhibitor Exhibits Oral Bioavailability and Therapeutic Efficacy in Acute Myeloid Leukemia. DOI:10.1021/acsmedchemlett.9b00471
AES-350 Preparation Products And Raw materials
Raw materials
Preparation Products
AES-350 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4859 | 55 | |
| Shanghai Beckham Medical Technology Co., Ltd | 13816613772 | huahero21@sina.com | China | 2994 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Shanghai Rechem science Co., Ltd. | 021-31433387 15618786686 | sales@rechemscience.com | China | 2969 | 58 |
| Shanghai SuperLan Chemcial Technique Centre | 0-2022843681 15618226720 | chaolaichem@foxmail.com | China | 9996 | 58 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6378 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
847249-57-4 (AES-350) Related Search:
1of2
