1H-Pyrazole-1-pentanoic acid, 5-(2-chloro-7-ethoxy-3-quinolinyl)-4,5-dihydro-3-(4-iodophenyl)-δ-oxo-
- CAS No.
- 1644626-43-6
- Chemical Name:
- 1H-Pyrazole-1-pentanoic acid, 5-(2-chloro-7-ethoxy-3-quinolinyl)-4,5-dihydro-3-(4-iodophenyl)-δ-oxo-
- Synonyms
- TDRL551;TDRL 551;TDRL-551;TDRL 551,TDRL551;TDRL-551, 10 mM in DMSO;1H-Pyrazole-1-pentanoic acid, 5-(2-chloro-7-ethoxy-3-quinolinyl)-4,5-dihydro-3-(4-iodophenyl)-δ-oxo-;5-(5-(2-Chloro-7-ethoxyquinolin-3-yl)-3-(4-iodophenyl)-4,5-dihydro-1H-pyrazol-1-yl)-5-oxopentanoic acid
- CBNumber:
- CB28693460
- Molecular Formula:
- C25H23ClIN3O4
- Molecular Weight:
- 591.83
- MDL Number:
- MOL File:
- 1644626-43-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
1H-Pyrazole-1-pentanoic acid, 5-(2-chloro-7-ethoxy-3-quinolinyl)-4,5-dihydro-3-(4-iodophenyl)-δ-oxo- Properties
| Boiling point | 704.0±70.0 °C(Predicted) |
|---|---|
| Density | 1.62±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO : 62.5 mg/mL (105.60 mM; Need ultrasonic) |
| pka | 4.65±0.10(Predicted) |
| form | Solid |
| color | Off-white to light yellow |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319 |
| Precautionary statements | P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330 |
1H-Pyrazole-1-pentanoic acid, 5-(2-chloro-7-ethoxy-3-quinolinyl)-4,5-dihydro-3-(4-iodophenyl)-δ-oxo- price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0064451 | TDRL-551 99.84% | 1644626-43-6 | 5mg | $227 | 2026-06-04 | Buy |
| ChemScene | CS-0064451 | TDRL-551 99.84% | 1644626-43-6 | 10mg | $368 | 2026-06-04 | Buy |
| ChemScene | CS-0064451 | TDRL-551 99.84% | 1644626-43-6 | 25mg | $737 | 2026-06-04 | Buy |
| ChemScene | CS-0064451 | TDRL-551 99.84% | 1644626-43-6 | 50mg | $1170 | 2026-06-04 | Buy |
| ChemScene | CS-0064451 | TDRL-551 99.84% | 1644626-43-6 | 100mg | $1874 | 2026-06-04 | Buy |
1H-Pyrazole-1-pentanoic acid, 5-(2-chloro-7-ethoxy-3-quinolinyl)-4,5-dihydro-3-(4-iodophenyl)-δ-oxo- Chemical Properties, Uses, Production
Uses
TDRL-551 is a potent replication protein A (RPA) inhibitor (IC50=18 μM). TDRL-551 inhibits RPA-DNA interaction and increases the efficacy of Platinum (Pt)-based chemotherapy in lung and ovarian cancer. RPA plays essential roles in both nucleotide excision repair (NER) and homologous recombination (HR), along with its role in DNA replication and DNA damage checkpoint activation[1].
Biological Activity
TDRL-551 is a potent replication protein A (RPA) inhibitor (IC50=18 μM). TDRL-551 inhibits RPA-DNA interaction and increases the efficacy of Platinum (Pt)-based chemotherapy in lung and ovarian cancer. RPA plays essential roles in both nucleotide excision repair (NER) and homologous recombination (HR), along with its role in DNA replication and DNA damage checkpoint activation[1].
References
[1]. Mishra AK, et al. Chemical inhibitor targeting the replication protein A-DNA interaction increases the efficacy of Pt-based chemotherapy in lung and ovarian cancer. Biochem Pharmacol. 2015;93(1):25-33.
1H-Pyrazole-1-pentanoic acid, 5-(2-chloro-7-ethoxy-3-quinolinyl)-4,5-dihydro-3-(4-iodophenyl)-δ-oxo- Preparation Products And Raw materials
Raw materials
Preparation Products
1H-Pyrazole-1-pentanoic acid, 5-(2-chloro-7-ethoxy-3-quinolinyl)-4,5-dihydro-3-(4-iodophenyl)-δ-oxo- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Wuhan TCASChem Technology Co., Ltd. | 027-86697669 13986148687 | sales@tcaschem.com | China | 3999 | 55 |
| Block Chemical Technology (Shanghai) Co., Ltd. | 021-20432219 13918097649 | li_jinfei@acblock-lab.com | China | 10032 | 58 |
| Block Chemical Technology (Shanghai) Co., Ltd. | 021-20432219 13918097649 | li_jinfei@acblock-lab.com | China | 10000 | 58 |
| Bide Pharmatech Ltd. | 400-1647117 13681763483 | product02@bidepharm.com | China | 59929 | 58 |
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 5985 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
| Beijing Boorsen Biotechnology Co., Ltd | 400-901-9800 18611424007 | cis@bioss.com.cn | China | 9185 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| Shanghai Amole Biotechnology Co., Ltd. | 13370042665 18916960931 | 2596183085@qq.com | China | 17234 | 58 |
| Shanghai Anbida Biotechnology Co., Ltd. | 021-61629020 18201956406 | sales@ambeed.cn | China | 7032 | 58 |
