Gefarnate
- CAS No.
- 51-77-4
- Chemical Name:
- Gefarnate
- Synonyms
- DA 688;Arsanyl;Terpanil;Gefarnyl;Arsanate;GEFRNATE;Alsanate;Gifarnate;gefarnate;Dixnalate
- CBNumber:
- CB2875370
- Molecular Formula:
- C27H44O2
- Molecular Weight:
- 400.64
- MDL Number:
- MFCD00129086
- MOL File:
- 51-77-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 25°C |
|---|---|
| Boiling point | bp0.05 165-168° |
| Density | 1.0044 (rough estimate) |
| refractive index | nD20 1.4900 |
| storage temp. | 2-8°C |
| solubility | DMSO:31.25(Max Conc. mg/mL);78.0(Max Conc. mM) |
| form | Oil |
| color | Clear Colourless |
| Stability | Light Sensitive |
| InChI | 1S/C27H44O2/c1-22(2)12-8-14-24(5)16-10-17-25(6)18-11-19-27(28)29-21-20-26(7)15-9-13-23(3)4/h12-13,16,18,20H,8-11,14-15,17,19,21H2,1-7H3/b24-16+,25-18+,26-20+ |
| InChIKey | ZPACYDRSPFRDHO-ROBAGEODSA-N |
| SMILES | CC(C)=CCC/C(C)=C/COC(CC/C=C(CC/C=C(CCC=C(C)C)\C)\C)=O |
| FDA UNII | 1ISE2Y6ULA |
| ATC code | A02BX07 |
| EPA Substance Registry System | 4,8,12-Tetradecatrienoic acid, 5,9,13-trimethyl-, (2E)-3,7-dimethyl-2,6-octadienyl ester, (4E,8E)- (51-77-4) |
| UNSPSC Code | 51111800 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| WGK Germany | WGK 3 |
| TSCA | TSCA listed |
| Storage Class | 10 - Combustible liquids |
Gefarnate price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | TRC-G303500-500MG | Gefarnate (Mixture of Isomers) | 51-77-4 | 500mg | $249 | 2026-06-03 | Buy |
| TRC | TRC-G303500-250MG | Gefarnate (Mixture of Isomers) | 51-77-4 | 250mg | $208 | 2026-06-03 | Buy |
| TRC | TRC-G303500-2.5G | Gefarnate (Mixture of Isomers) | 51-77-4 | 2.5g | $944 | 2026-06-03 | Buy |
| Biosynth | FG40726 | Gefarnate | 51-77-4 | 100mg | $150 | 2026-06-04 | Buy |
| ChemScene | CS-7652 | Gefarnate 98.0% | 51-77-4 | 50mg | $54 | 2026-06-04 | Buy |
Gefarnate Chemical Properties, Uses, Production
Uses
Gefarnate is a synthetic isoprenoid that is used to treat chronic gastric and duodenic ulcers. Gerfarnate is also used for gastric ulcer prophylaxis.
Definition
ChEBI: Gefarnate is an organic molecular entity.
Biological Activity
Gefarnate is an anti-ulcer drug th at stimulates gastric mucin secretion. Also gefarnate increase secretion of mucin-like glycoprotein in rabbit conjunctival tissue. It appears to be effective in animal dry-eye models. It is approved in Japan, where it is used to tre at gastritis and gastric ulcer. Gefarnate is structurally similar to anti-ulcer drug teprenone (geranyl farnesylacetate), which induces expression of HSP70, HSPB8, and HSPB1.
Synthesis
106-24-1
6040-06-8
51-77-4
The general procedure for the synthesis of (4E,8E)-(E)-3,7-dimethylocta-2,6-dien-1-yl 5,9,13-trimethyltetradeca-4,8,12-trienoate from geraniol and (4E,8E)-5,9,13-trimethyltetradeca-4,8,12-trienoate was performed as follows: 10.3 g farnesyl acetic acid, 15.0 g g geraniol, 25.0 mL xylene and 0.43 g hydroquinone were mixed and refluxed for about 10 hours. The progress of the reaction was monitored during the reaction using thin layer chromatography (TLC with a spreader ratio of petroleum ether/ethyl acetate = 25:1) and the complete reaction of farnesylacetic acid was confirmed by TLC (spreader ratio of petroleum ether/ethyl acetate = 5:1). Upon completion of the reaction, an orange-yellow transparent mixed solution was obtained, which was slightly cooled and xylene was removed by distillation under reduced pressure. The residue was extracted 2-3 times with hexane and 1% (w/w) sodium hydroxide solution, the organic phase was separated, dried and some of the solvent was removed by rotary evaporation. The residue was dried over anhydrous calcium chloride and the mixture was stirred overnight at room temperature and the filtrate was collected by filtration. The filtrate was concentrated to give the crude product of gefarnate ester. The crude product was purified by reduced pressure distillation and the 186-200 °C fraction was collected to give the pure gefarnate ester product.
References
[1] Patent: CN103012140, 2016, B. Location in patent: Paragraph 0071; 0074; 0093
Gefarnate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Shanghai Ennopharm Co., Ltd. | +86 (21) 6435-5022 | China | 4263 | 65 | |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| AdooQ BioScience, LLC | +1 (866) 930-6790 | info@adooq.com | United States | 2774 | 58 |
| Shanghai Yongye Biotechnology Co., Ltd. | 86-021-61559134 15921386130 | 3423497944@qq.com | China | 8135 | 55 |
| AdooQ Bioscience CHINA | 025-58849295 | info@adooq.cn | China | 2981 | 60 |
| Chizhou Kailong Import and Export Trade Co., Ltd. | xg01_gj@163.com | China | 9413 | 50 | |
| Nanjing Chempioneer Pharmaceutical Co., Ltd. | 18068075658 | sales@chempioneer.com | China | 1803 | 58 |
| Pharmacodia (Beijing) Co.,Ltd | +86-400-851-9921 | sales@pharmacodia.com | China | 2308 | 55 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
View Latest Price from Gefarnate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-22 | Gefarnate
51-77-4
|
$38.00-56.00 | 98.36% | 10g | TargetMol Chemicals Inc. | ||
 |
2021-07-02 | Gefarnate
51-77-4
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2019-07-06 | Gefarnate
51-77-4
|
$7.00 | 1KG | 99% | 1000KG | Career Henan Chemical Co |
