metipranolol
- CAS No.
- 22664-55-7
- Chemical Name:
- metipranolol
- Synonyms
- Disorat;Glausyn;Glauline;VUFB-6453;Trimepranol;Methypranol;4-(2-HYDROXY-3-(ISOPROPYLAMINO)PROPOXY)-2,3,6-TRIMETHYLPHENYL ACETATE;4-[2-Hydroxy-3-[(1-methylethyl)amino]propoxy]-2,3,6-trimethylphenol 1-acetate;Phenol, 4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]-2,3,6-trimethyl-, 1-acetate;stress,Metipranolol,Beta Receptor,glaucoma,lipid,Adrenergic Receptor,antioxidant,peroxidation,inhibit,Nitrosative,Inhibitor,hypertension
- CBNumber:
- CB2880767
- Molecular Formula:
- C17H27NO4
- Molecular Weight:
- 309.4
- MDL Number:
- MFCD00864567
- MOL File:
- 22664-55-7.mol
| Product description | Number | Pack Size | Price |
| 4-(2-HYDROXY-3-(ISOPROPYLAMINO)PROPOXY)-2,3,6-TRIMETHYLPHENYL ACETATE AldrichCPR | R736139 | 1 unit | $143 |
| Metipranolol British Pharmacopoeia (BP) Reference Standard | BP642 | 100 mg | $286 |
| 4-(2-HYDROXY-3-(ISOPROPYLAMINO)PROPOXY)-2,3,6-TRIMETHYLPHENYL ACETATE Aldrich | R736139 | 10mg | $139 |
| Metipranolol 98.36% | CS-0082752 | 50mg | $380 |
| Metipranolol 98.36% | CS-0082752 | 100mg | $620 |
| Melting point | 105-107℃ |
|---|---|
| Boiling point | 458.7±45.0 °C(Predicted) |
| Density | 1.068 |
| storage temp. | 4°C, protect from light |
| solubility | DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:6): 0.14 mg/ml; DMSO: 20 mg/ml; Ethanol: 10 mg/ml |
| pka | 13.91±0.20(Predicted) |
| form | A crystalline solid |
| color | White to off-white |
| InChI | InChI=1S/C17H27NO4/c1-10(2)18-8-15(20)9-21-16-7-11(3)17(22-14(6)19)13(5)12(16)4/h7,10,15,18,20H,8-9H2,1-6H3 |
| InChIKey | BQIPXWYNLPYNHW-UHFFFAOYSA-N |
| SMILES | C1(OC(=O)C)=C(C)C=C(OCC(O)CNC(C)C)C(C)=C1C |
| FDA UNII | X39AL81KEB |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H411-H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P330-P501 | |||||||||
| Toxicity | LD50 in mice (mg/kg): 31 i.v. (Bartsch) | |||||||||
| NFPA 704 |
|
metipranolol price More Price(10)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | R736139 | 4-(2-HYDROXY-3-(ISOPROPYLAMINO)PROPOXY)-2,3,6-TRIMETHYLPHENYL ACETATE AldrichCPR | 22664-55-7 | 1 unit | $143 | 2025-07-31 | Buy |
| Sigma-Aldrich | BP642 | Metipranolol British Pharmacopoeia (BP) Reference Standard | 22664-55-7 | 100 mg | $286 | 2025-07-31 | Buy |
| Sigma-Aldrich | R736139 | 4-(2-HYDROXY-3-(ISOPROPYLAMINO)PROPOXY)-2,3,6-TRIMETHYLPHENYL ACETATE Aldrich | 22664-55-7 | 10mg | $139 | 2024-03-01 | Buy |
| ChemScene | CS-0082752 | Metipranolol 98.36% | 22664-55-7 | 50mg | $380 | 2021-12-16 | Buy |
| ChemScene | CS-0082752 | Metipranolol 98.36% | 22664-55-7 | 100mg | $620 | 2021-12-16 | Buy |
metipranolol Chemical Properties,Uses,Production
Uses
Antihypertensive (β-blocker, ophthalmic).
Definition
ChEBI: 3-(Propan-2-ylamino)propane-1,2-diol in which the hydrogen of the primary hydroxy group is substituted by a 4-acetoxy-2,3,5-trimethylphenoxy group. A non-cardioselective beta-blocker, it is used to lower intra-ocular pressure in the management of open-angl glaucoma.
brand name
OptiPranolol (Bausch & Lomb Pharmaceuticals).
in vivo
At postnatal day 35 (P35), rd10 mice given daily subcutaneous injections of 40 mg/kg of Metipranolol has reduction in markers of nitrosative stress, fewer TUNEL-positive cells, increased outer nuclear layer thickness, and substantially more staining for rhodopsin. At P50, Metipranolol-treated rd10 mice has decreased 3-nitrotyrosine staining in the retina, increased immunostaining for cone arrestin, a marker for cone photoreceptors, and significantly higher scotopic and photopic b-wave amplitudes at the highest stimulus intensity. At P65, cone density is significantly higher in Metipranolol-treated versus vehicle-injected rd10 mice[1].
IC 50
β1 adrenoceptor: 8.3 (pA2); β2 adrenoceptor: 8.4 (pA2)
metipranolol Preparation Products And Raw materials
Raw materials
Preparation Products
metipranolol Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
| AFINE CHEMICALS LIMITED | +86-0571-85134551 | sales@afinechem.com | China | 15080 | 58 |
| ChemeGen | 18818260767 | 2625930290@qq.com | China | 6973 | 58 |
| Beijing HuaMeiHuLiBiological Chemical | 010-56205725 | waley188@sohu.com | China | 12335 | 58 |
| Shanghaizehan biopharma technology co., Ltd. | 021-61350663 13052117465 | sales@zehanbiopharma.com | China | 983 | 55 |
| Heze Development Zone chuangli Chemical Co., Ltd. | 0530-+86-530-529 6766，+86-15666160102 15666160102 | info@chuangli-chem.com | China | 838 | 55 |
| Changzhou Chenhong Biotechnology Co., Ltd. | +86-0519-85788828 +86-13775037613 | sales@chemrenpharm.com | China | 4023 | 58 |
| Shanghai Luofa Biochemical Technology Co., Ltd. | 021-51111890 15317326293 | sales@molnova.com | China | 4195 | 58 |
| Zhuhai Anzhe Biotechnology Co,Ltd. | 13169972583 | 513211116@qq.com | China | 3005 | 58 |
