ChemicalBook >> CAS DataBase List >>2,4-Pyrimidinediamine, 5-chloro-N2-[2,3-dihydro-7-methyl-8-(4-piperidinyl)-1,4-benzodioxin-5-yl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-

2,4-Pyrimidinediamine, 5-chloro-N2-[2,3-dihydro-7-methyl-8-(4-piperidinyl)-1,4-benzodioxin-5-yl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-

2,4-Pyrimidinediamine, 5-chloro-N2-[2,3-dihydro-7-methyl-8-(4-piperidinyl)-1,4-benzodioxin-5-yl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]- structure

CAS No.: 1893419-37-8

Chemical Name:: 2,4-Pyrimidinediamine, 5-chloro-N2-[2,3-dihydro-7-methyl-8-(4-piperidinyl)-1,4-benzodioxin-5-yl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-

Synonyms: 5-chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(7-methyl-8-(piperidin-4-yl)-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrimidine-2,4-diamine;2,4-Pyrimidinediamine, 5-chloro-N2-[2,3-dihydro-7-methyl-8-(4-piperidinyl)-1,4-benzodioxin-5-yl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-

CBNumber:: CB28851255

Molecular Formula:: C27H32ClN5O4S

Molecular Weight:: 558.09

MDL Number:

MOL File:: 1893419-37-8.mol

Last updated:2025-04-17 18:22:24

Request For Quotation

2,4-Pyrimidinediamine, 5-chloro-N2-[2,3-dihydro-7-methyl-8-(4-piperidinyl)-1,4-benzodioxin-5-yl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]- Properties

Boiling point	717.6±70.0 °C(Predicted)
Density	1.336±0.06 g/cm3(Predicted)
pka	10.11±0.10(Predicted)

2,4-Pyrimidinediamine, 5-chloro-N2-[2,3-dihydro-7-methyl-8-(4-piperidinyl)-1,4-benzodioxin-5-yl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]- Chemical Properties, Uses, Production

Uses

Dirozalkib (Compound 4) is the inhibitor for ALK with an IC50 of 0.9 nM. Dirozalkib exhibits anti-proliferative activity in cancer cells NCI-H3122, Karpas-299 and NCI-H2228 with IC50s of 130.4, 0.71 and 15.11 nM, respectively. Dirozalkib exhibits good pharmacokinetics characteristics with an bioavailbility of 30%~50%[1].

References

[1] Wu Y, et al., Polycyclic anaplastic lymphoma kinase inhibitor. WO2016050171

2,4-Pyrimidinediamine, 5-chloro-N2-[2,3-dihydro-7-methyl-8-(4-piperidinyl)-1,4-benzodioxin-5-yl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

2,4-Pyrimidinediamine, 5-chloro-N2-[2,3-dihydro-7-methyl-8-(4-piperidinyl)-1,4-benzodioxin-5-yl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]- Suppliers

Global Suppliers ( 3)

Supplier	Tel	Email	Country	ProdList	Advantage
ChemShuttle, Inc.	0510-83588313-811 18800520310	sales@chemshuttle.com	China	2999	62
Nantong Hi-Future Biotechnology Co., Ltd	+86-0513; 18051384581	sales@chemhifuture.com	China	3075	58
Afflon Pharmaceutical (Sichuan) Co., Ltd.	17336178085	1684779048@qq.com	China	2263	58

Supplier	Advantage
ChemShuttle, Inc.	62
Nantong Hi-Future Biotechnology Co., Ltd	58
Afflon Pharmaceutical (Sichuan) Co., Ltd.	58

1893419-37-8 (2,4-Pyrimidinediamine, 5-chloro-N2-[2,3-dihydro-7-methyl-8-(4-piperidinyl)-1,4-benzodioxin-5-yl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-) Related Search:

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2,4-Pyrimidinediamine, 5-chloro-N2-[2,3-dihydro-7-methyl-8-(4-piperidinyl)-1,4-benzodioxin-5-yl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]- 5-chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(7-methyl-8-(piperidin-4-yl)-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrimidine-2,4-diamine 1893419-37-8 C27H32ClN5O4S