(5alpha,8alpha,9alpha)-5,8,9,10-tetrahydro-5,9-methanobenzocycloocten-8-ylammonium chloride
- CAS No.
- 67384-25-2
- Chemical Name:
- (5alpha,8alpha,9alpha)-5,8,9,10-tetrahydro-5,9-methanobenzocycloocten-8-ylammonium chloride
- Synonyms
- Org-6906 free;(5alpha,8alpha,9alpha)-5,8,9,10-tetrahydro-5,9-methanobenzocycloocten-8-ylammonium chloride
- CBNumber:
- CB2893130
- Molecular Formula:
- C13H16ClN
- Molecular Weight:
- 221.73
- MDL Number:
- MFCD32182626
- MOL File:
- 67384-25-2.mol
(5alpha,8alpha,9alpha)-5,8,9,10-tetrahydro-5,9-methanobenzocycloocten-8-ylammonium chloride Chemical Properties, Uses, Production
Description
Org-6906 is a dual of monoamine uptake inhibitor and α2 adrenoceptor antagonist potentially for the treatment. Org-6906 facilitated potassium-stimulated release of noradrenaline from slices of cortex, displaced [3H]rauwolscine and [3H]dihydroergocryptine from their binding sites but only weakly blocked alpha 1-adrenoceptors. The alpha 2-adrenolytic properties were also apparent in behavioural interaction models. The compound antagonized the sleep-inducing effects of clonidine in chicks and mice and it antagonized the mydriasis induced by clonidine in the rat.
Uses
Org 6906 is a monoamine reuptake inhibitor that promotes monoaminergic neurotransmission by inhibiting the reuptake of noradrenaline, dopamine, and serotonin. Org 6906 is also an α2 Adrenergic Receptor antagonist, with a pKi value of 6.3 (using the selective α2 adrenergic receptor ligand [3H]rauwolscine as a ligand). Org 6906 exhibits antidepressant activity and can be used in research related to neurological disorders[1].
IC 50
α2-adrenergic receptor: 6.5 (pKi)
References
[1] de Boer T, et al. The pharmacological profile of Org 6906, a potential non-sedative antidepressant that combines monoamine uptake inhibition with alpha 2-adrenolytic activity. Neuropharmacology. 1988 Mar;27(3):251-60. DOI:10.1016/0028-3908(88)90041-x
(5alpha,8alpha,9alpha)-5,8,9,10-tetrahydro-5,9-methanobenzocycloocten-8-ylammonium chloride Preparation Products And Raw materials
Raw materials
Preparation Products
(5alpha,8alpha,9alpha)-5,8,9,10-tetrahydro-5,9-methanobenzocycloocten-8-ylammonium chloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49709 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
| TargetMol Chemicals Inc. | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | 58 |
