ChemicalBook >> CAS DataBase List >>4-Isothiazolecarbonitrile, 2,3-dihydro-3-oxo-5-[[2-(trifluoromethyl)phenyl]amino]-

4-Isothiazolecarbonitrile, 2,3-dihydro-3-oxo-5-[[2-(trifluoromethyl)phenyl]amino]-

4-Isothiazolecarbonitrile, 2,3-dihydro-3-oxo-5-[[2-(trifluoromethyl)phenyl]amino]- structure

CAS No.: 287196-91-2

Chemical Name:: 4-Isothiazolecarbonitrile, 2,3-dihydro-3-oxo-5-[[2-(trifluoromethyl)phenyl]amino]-

Synonyms: 3-Hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles;4-Isothiazolecarbonitrile,2,3-dihydro-3-oxo-5-[[2-(trifluoromethyl)phenyl]a;3-Oxo-5-[[2-(trifluoromethyl)phenyl]amino]-2,3-dihydroisothiazole-4-carbonitrile;4-Isothiazolecarbonitrile, 2,3-dihydro-3-oxo-5-[[2-(trifluoromethyl)phenyl]amino]-

CBNumber:: CB28964809

Molecular Formula:: C11H6F3N3OS

Molecular Weight:: 285.24

MDL Number:

MOL File:: 287196-91-2.mol

MSDS File:: SDS

Last updated:2025-04-18 09:51:56

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4-Isothiazolecarbonitrile, 2,3-dihydro-3-oxo-5-[[2-(trifluoromethyl)phenyl]amino]- Properties

Density	1.56±0.1 g/cm3(Predicted)
pka	5.95±0.60(Predicted)
form	Solid
color	White to off-white

4-Isothiazolecarbonitrile, 2,3-dihydro-3-oxo-5-[[2-(trifluoromethyl)phenyl]amino]- price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
ChemScene	CS-0343338	3-Hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles 99.84%	287196-91-2	5mg	$152	2026-06-04	Buy
ChemScene	CS-0343338	3-Hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles 99.84%	287196-91-2	10mg	$244	2026-06-04	Buy
ChemScene	CS-0343338	3-Hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles 99.84%	287196-91-2	25mg	$487	2026-06-04	Buy
ChemScene	CS-0343338	3-Hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles 99.84%	287196-91-2	50mg	$780	2026-06-04	Buy
ChemScene	CS-0343338	3-Hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles 99.84%	287196-91-2	100mg	$1246	2026-06-04	Buy

Product number	Packaging	Price	Buy
CS-0343338	5mg	$152	Buy
CS-0343338	10mg	$244	Buy
CS-0343338	25mg	$487	Buy
CS-0343338	50mg	$780	Buy
CS-0343338	100mg	$1246	Buy

4-Isothiazolecarbonitrile, 2,3-dihydro-3-oxo-5-[[2-(trifluoromethyl)phenyl]amino]- Chemical Properties, Uses, Production

Uses

3-Hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles is an inhibitor for bone morphogenetic protein 2 (BMP2) with an IC50 of 2.2 μM. 3-Hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles is inhibitor for mitogen-activated protein kinase 1 (MEK1). 3-Hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles exhibits anti-inflammatory and neuroprotective activity in EAE mouse model[1][2].

References

[1] Arnon KARNI, Small organic molecules for use in the treatment of neuroinflammatory disorders. WO2018198123.
[2] Varaprasad CV, et al., Discovery of 3-hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles as potent MEK1 inhibitors. Bioorg Med Chem Lett. 2006 Aug 1;16(15):3975-80. DOI:10.1016/j.bmcl.2006.05.019

4-Isothiazolecarbonitrile, 2,3-dihydro-3-oxo-5-[[2-(trifluoromethyl)phenyl]amino]- Preparation Products And Raw materials

Raw materials

Preparation Products

4-Isothiazolecarbonitrile, 2,3-dihydro-3-oxo-5-[[2-(trifluoromethyl)phenyl]amino]- Suppliers

Global Suppliers ( 5)

Supplier	Tel	Email	Country	ProdList	Advantage
Accela ChemBio Inc.	+1-858-6993322 +86-18019713315	info@accelachem.com	United States	21189	58
Accela ChemBio Co.,Ltd.	021-50795510 4000665055	marketing@accelachem.com	China	10452	58
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	29874	58

Supplier	Advantage
Accela ChemBio Inc.	58
Accela ChemBio Co.,Ltd.	58
TargetMol Chemicals Inc.	58

287196-91-2 (4-Isothiazolecarbonitrile, 2,3-dihydro-3-oxo-5-[[2-(trifluoromethyl)phenyl]amino]-) Related Search:

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4-Isothiazolecarbonitrile, 2,3-dihydro-3-oxo-5-[[2-(trifluoromethyl)phenyl]amino]- 4-Isothiazolecarbonitrile,2,3-dihydro-3-oxo-5-[[2-(trifluoromethyl)phenyl]a 3-Oxo-5-[[2-(trifluoromethyl)phenyl]amino]-2,3-dihydroisothiazole-4-carbonitrile 3-Hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles 287196-91-2