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ChemicalBook >> CAS DataBase List >>Acetic acid, 2-[4-[5-(3-chlorophenoxy)oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethylphenoxy]-

Acetic acid, 2-[4-[5-(3-chlorophenoxy)oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethylphenoxy]-

Acetic acid, 2-[4-[5-(3-chlorophenoxy)oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethylphenoxy]- Structure
Acetic acid, 2-[4-[5-(3-chlorophenoxy)oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethylphenoxy]- structure
CAS No.
1315311-14-8
Chemical Name:
Acetic acid, 2-[4-[5-(3-chlorophenoxy)oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethylphenoxy]-
Synonyms
SAR247799;S1P1 agonist 3;{4-[5-(3-chlorophenoxy)oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethylphenoxy}acetic acid;Acetic acid, 2-[4-[5-(3-chlorophenoxy)oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethylphenoxy]-
CBNumber:
CB29323841
Molecular Formula:
C21H16ClN3O5
Molecular Weight:
425.82
MDL Number:
MOL File:
1315311-14-8.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-04-24 14:58:50
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Acetic acid, 2-[4-[5-(3-chlorophenoxy)oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethylphenoxy]- Properties

Boiling point 618.9±65.0 °C(Predicted)
Density 1.412±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
pka 3.07±0.10(Predicted)
form Solid
color Off-white to light yellow

Acetic acid, 2-[4-[5-(3-chlorophenoxy)oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethylphenoxy]- price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0368765 SAR247799 99.38% 1315311-14-8 5mg $520 2026-06-04 Buy
ChemScene CS-0368765 SAR247799 99.38% 1315311-14-8 10mg $867 2026-06-04 Buy
ChemScene CS-0368765 SAR247799 99.38% 1315311-14-8 25mg $1787 2026-06-04 Buy
ChemScene CS-0368765 SAR247799 99.38% 1315311-14-8 50mg $2817 2026-06-04 Buy
ChemScene CS-0368765 SAR247799 99.38% 1315311-14-8 100mg $4333 2026-06-04 Buy
Product number Packaging Price Buy
CS-0368765 5mg $520 Buy
CS-0368765 10mg $867 Buy
CS-0368765 25mg $1787 Buy
CS-0368765 50mg $2817 Buy
CS-0368765 100mg $4333 Buy

Acetic acid, 2-[4-[5-(3-chlorophenoxy)oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethylphenoxy]- Chemical Properties, Uses, Production

Description

SAR247799 is a novel G-protein-biased sphingosine-1 phosphate receptor-1 (S1P1) agonist.

Uses

SAR247799 (S1P1 agonist 3) is an oral activity, selective G-protein-biased sphingosine-1 phosphate receptor-1 (S1P1 ) agonist, with EC50s rang from 12.6 to 493 nM in S1P1-overexpressing cells and HUVECs. SAR247799 can be used for the research of endothelial protection, including type-2 diabetes, metabolic syndrome[1][2][3][4].

in vivo

SAR247799 (1 and 3 mg/kg; p.o.; 1 h before renal occlusion) dose dependently reduces the severity of ischemia/reperfusion (I/R)–induced acute kidney injury[1].
SAR247799 (0.3, 1, 3 mg/kg; i.v.) dose dependently increases the coronary conductance ratio in pig model of coronary endothelial dysfunction[1].
SAR247799 (30-min intravenous administration; 8- to 10-week-old farm pig) exposure (Cmax and AUC) increases with dose in pigs. Pharmacokinetic parameters [1]:

Dose (mg/kg)NCmax (g/mL)Tmax (h)Tlast (h)AUC0-last (g.h/mL)Cl (L/h/kg)Vss (L/kg)T1/2z (h)
142.08 (8)0.5 [0.5][8-48]11.8 (46)0.113 (75)0.516 (11)5.62 (57)
378.10 (12)0.5 [0.5][24-72]42.2 (23)0.0754 (30)0.446 (16)6.21 (28)
10336.7 (5)0.5 [0.5-0.75]72294 (13)0.0343 (13)0.338 (7)7.73 (8)
306112 (27)0.5 [0.5- 1.0][48-72]908 (16)0.0338 (18)0.294 (11)7.35 (11)
Mean values with (CV%) except Tmax, which is expressed as median value with [range] and Tlast as [range]. Cmax, maximum concentration. Tmax, time at which maximum concentration achieved. Tlast, last time point sampled. AUC0-last, area under curve from 0 to last time point. Cl, clearance. Vss, volume at steady state or volume of distribution. T1/2z, elimination half-life. N, number of animals.
Animal Model:Acute kidney injury rats (12 to 15-week-old Fischer rats)[1]
Dosage:1 and 3 mg/kg
Administration:P.o.; administered 1 hour before renal occlusion.
Result:Inhibited the increase in serum creatinine (89 and 96% at 1 and 3 mg/kg) and urea (61 and 85% at 1 and 3 mg/kg).
Protected renal proximal tubules against necrosis and blunted the development of interstitial hemorrhage.
Animal Model:Acute kidney injury rats (8- to 12-week-old Fischer rats)[1]
Dosage:3 mg/kg
Administration:P.o.; twice a day for 7 days and twice a day for 7 day
Result:Showed a dosedependent trend for reducing macrophage.

IC 50

S1PR1: 12.6-493 nM (EC50)

References

[1] Poirier B, et al. A G protein-biased S1P1 agonist, SAR247799, protects endothelial cells without affecting lymphocyte numbers. Sci Signal. 2020 Jun 2;13(634):eaax8050. DOI:10.1126/scisignal.aax8050
[2] Evaristi MF, et al. A G-protein-biased S1P1 agonist, SAR247799, improved LVH and diastolic function in a rat model of metabolic syndrome. PLoS One. 2022 Jan 14;17(1):e0257929. DOI:10.1371/journal.pone.0257929
[3] Bergougnan L, et al. Endothelial-protective effects of a G-protein-biased sphingosine-1 phosphate receptor-1 agonist, SAR247799, in type-2 diabetes rats and a randomized placebo-controlled patient trial. Br J Clin Pharmacol. 2021 May;87(5):2303-2320. DOI:10.1111/bcp.14632
[4] Bergougnan L, et al. First-in-human study of the safety, tolerability, pharmacokinetics and pharmacodynamics of single and multiple oral doses of SAR247799, a selective G-protein-biased sphingosine-1 phosphate receptor-1 agonist for endothelial protection DOI:10.1111/bcp.14422

Acetic acid, 2-[4-[5-(3-chlorophenoxy)oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethylphenoxy]- Preparation Products And Raw materials

Raw materials

Preparation Products

Acetic acid, 2-[4-[5-(3-chlorophenoxy)oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethylphenoxy]- Suppliers

Global Suppliers ( 6)
Supplier Tel Email Country ProdList Advantage
Shanghai Merlot Chemical Co., LTD 15821661757 226174156@qq.com China 476 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11963 58
RD International Technology Co., Limited 18024082417 market@ubiochem.com China 9831 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 29873 58
Shanghai Amole Biotechnology Co., Ltd. 13370042665 18916960931 2596183085@qq.com China 17234 58
Hebei Yaocheng Pharmaceutical Technology Co. Ltd 19903117580 19903117510 yc-eliu@yaochengph.com China 9949 58
Supplier Advantage
Shanghai Merlot Chemical Co., LTD 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
RD International Technology Co., Limited 58
TargetMol Chemicals Inc. 58
Shanghai Amole Biotechnology Co., Ltd. 58
Hebei Yaocheng Pharmaceutical Technology Co. Ltd 58

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Acetic acid, 2-[4-[5-(3-chlorophenoxy)oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethylphenoxy]- S1P1 agonist 3 {4-[5-(3-chlorophenoxy)oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethylphenoxy}acetic acid SAR247799 1315311-14-8