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(R)-N-Boc-2-Hydroxymethylmorpholine

(R)-N-Boc-2-Hydroxymethylmorpholine Structure
(R)-N-Boc-2-Hydroxymethylmorpholine structure
CAS No.
135065-71-3
Chemical Name:
(R)-N-Boc-2-Hydroxymethylmorpholine
Synonyms
tert-butyl (2R)-2-(hydroxymethyl)morpholine-4-carboxylate;Evocalcet impurity 36;(R)-N-BOC-2-HYDROXYMETHYLMORPHOLINE;(R)-4-BOC-2-HYDROXYMETHYL-MORPHOLINE;(R)-2-hydroxyMethyl-4-BOC-Morpholine;(R)-N-Boc-2-hydroxymethylmorpholine,99%;(R)/(S)-N-Boc-2-hydroxymethylmorpholine;(R)-N-Boc-2-hydroxymethylmorpholine,99%e.e.;(R)-4-t-butoxycarbonyl-2-(hydroxymethyl)morpholine;Tert-Butyl(R)-2-(Hydroxymethyl)Morpholine-4-Carboxylate
CBNumber:
CB2958329
Molecular Formula:
C10H19NO4
Molecular Weight:
217.26
MDL Number:
MFCD09260605
MOL File:
135065-71-3.mol
MSDS File:
SDS
Last updated:2026-05-28 00:54:09
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(R)-N-Boc-2-Hydroxymethylmorpholine Properties

Melting point 59-61 °C
Boiling point 321 °C
Density 1.118
Flash point 148 °C
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
pka 14.36±0.10(Predicted)
InChI InChI=1S/C10H19NO4/c1-10(2,3)15-9(13)11-4-5-14-8(6-11)7-12/h8,12H,4-7H2,1-3H3/t8-/m1/s1
InChIKey FJYBLMJHXRWDAQ-MRVPVSSYSA-N
SMILES N1(C(OC(C)(C)C)=O)CCO[C@@H](CO)C1

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a
HS Code  2934999090
NFPA 704
1
2 0

(R)-N-Boc-2-Hydroxymethylmorpholine price More Price(72)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
AstaTech 55952 (R)-4-BOC-2-HYDROXYMETHYL-MORPHOLINE 97% 135065-71-3 1G $15 2026-04-30 Buy
AstaTech 55952 (R)-4-BOC-2-HYDROXYMETHYL-MORPHOLINE 97% 135065-71-3 5G $49 2026-04-30 Buy
AstaTech 55952 (R)-4-BOC-2-HYDROXYMETHYL-MORPHOLINE 97% 135065-71-3 25G $128 2026-04-30 Buy
Biosynth FB43598 (R)-N-Boc-2-Hydroxymethylmorpholine 135065-71-3 5g $150 2026-06-04 Buy
Biosynth FB43598 (R)-N-Boc-2-Hydroxymethylmorpholine 135065-71-3 2g $150 2026-06-04 Buy
Product number Packaging Price Buy
55952 1G $15 Buy
55952 5G $49 Buy
55952 25G $128 Buy
FB43598 5g $150 Buy
FB43598 2g $150 Buy

(R)-N-Boc-2-Hydroxymethylmorpholine Chemical Properties, Uses, Production

Uses

(R)-N-Boc-2-hydroxymethylmorpholine is used for preparation of inhibitors of Checkpoint Kinase 1 through template screening.

Synthesis

(R)-tert-butyl 2-((benzyloxy)methyl)morpholine-4-carboxylate

135097-68-6

(R)-N-Boc-2-Hydroxymethylmorpholine

135065-71-3

Intermediate 111 (19.8 g, 64.4 mmol) was stirred and reacted for 16 h under hydrogen atmosphere with 10% Pd/C (1.98 g, 1.86 mmol) as catalyst. Upon completion of the reaction, the catalyst was removed by vacuum filtration and the filtrate was concentrated under reduced pressure to afford 13.98 g (100% yield) of (R)-N-Boc-2-hydroxymethylmorpholine, the product was a colorless viscous oil that crystallized upon standing. The 1H NMR (250 MHz, chloroform-d) data of the product were as follows: δ [ppm] 3.98 - 3.75 (m, 3H), 3.73 - 3.41 (m, 4H), 3.03 - 2.83 (m, 1H), 2.82 - 2.65 (m, 1H), 2.12 (t, J = 5.9 Hz, 1H), 1.45 (s, 9H).

References

[1] Heterocycles, 1993, vol. 35, # 1, p. 105 - 109
[2] Patent: WO2016/91776, 2016, A1. Location in patent: Page/Page column 290
[3] Patent: WO2008/124575, 2008, A1. Location in patent: Page/Page column 112; 113-114
[4] Patent: US2010/184805, 2010, A1. Location in patent: Page/Page column 30-31
[5] Patent: WO2007/70201, 2007, A1. Location in patent: Page/Page column 176

(R)-N-Boc-2-Hydroxymethylmorpholine synthesis

135097-68-6
135065-71-3
Synthesis of (R)-N-Boc-2-Hydroxymethylmorpholine from (R)-tert-butyl 2-((benzyloxy)methyl)morpholine-4-carboxylate

(R)-N-Boc-2-Hydroxymethylmorpholine Preparation Products And Raw materials

Raw materials

4-Morpholinecarboxylic acid, 2-[[[(4-methylphenyl)sulfonyl]oxy]methyl]-, 1,1-dimethylethyl ester, (2R)- Acetamide, 2-chloro-N-[(2R)-2,3-dihydroxypropyl]- (R)-2-((benzyloxy)methyl)morpholine(WXC06858) (R)-tert-butyl 2-((benzyloxy)methyl)morpholine-4-carboxylate ((R)-morpholin-2-yl)methanol
(R)-4-(tert-Butoxycarbonyl)morpholine-2-carboxylic acid (R )-6-Hydroxymethyl-morpholin-3-one Di-tert-butyl dicarbonate Tosyl chloride 2-Morpholinemethanol, 4-[(4-methylphenyl)sulfonyl]-, (2R)-

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Preparation Products

(R)-N-Boc-2-Hydroxymethylmorpholine Suppliers

Global Suppliers ( 243)
Supplier Tel Email Country ProdList Advantage
Shanghai KeLy Bio-Pharmaceutical Co., Ltd. 13816253073 lige@kelybiopharm.com China 127 58
Doly Chemical CO.,LTD. 021-34716221 15800796336 sales@dolypharm.com China 294 55
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 025-66113011 13913916777 cfzhang@aikonchem.com China 19902 55
Chengdu Dorher Pharmaceutical CO.,Ltd 028-64259743 19983537320 wangmin@focuspharm.com China 498 58
Anhui Nature Pharmaceutical Co., Ltd. 19155667820 sales@nuoquanpharm.com China 131 58
MINKESH (SHANGHAI) CO., LTD. +86-021-20980300 +86-13167252998 sales@minkesh.com China 92 55
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Chembest Research Laboratories Limited 021-20908456 sales@BioChemBest.com China 5996 61
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Supplier Advantage
Shanghai KeLy Bio-Pharmaceutical Co., Ltd. 58
Doly Chemical CO.,LTD. 55
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 55
Chengdu Dorher Pharmaceutical CO.,Ltd 58
Anhui Nature Pharmaceutical Co., Ltd. 58
MINKESH (SHANGHAI) CO., LTD. 55
J & K SCIENTIFIC LTD. 76
Chembest Research Laboratories Limited 61
Alfa Aesar 84
Energy Chemical 61

View Latest Price from (R)-N-Boc-2-Hydroxymethylmorpholine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
(R)-N-Boc-2-Hydroxymethylmorpholine pictures 2026-08-20 (R)-N-Boc-2-Hydroxymethylmorpholine
135065-71-3
 $1.10 1g 99.0% Min 100 Tons Dideu Industries Group Limited
(R)-N-Boc-2-Hydroxymethylmorpholine pictures 2025-04-04 (R)-N-Boc-2-Hydroxymethylmorpholine
135065-71-3
 1kg 98% 1Ton Henan Aochuang Chemical Co.,Ltd.
(R)-N-Boc-2-hydroxymethylmorpholine pictures 2022-01-26 (R)-N-Boc-2-hydroxymethylmorpholine
135065-71-3
 1KG 98.1% 100 tons Honest Joy Holdings Limited

(R)-N-Boc-2-Hydroxymethylmorpholine Spectrum

(R)-N-Boc-2-Hydroxymethylmorpholine(135065-71-3)1HNMR

135065-71-3 ((R)-N-Boc-2-Hydroxymethylmorpholine) Related Search:

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(R)-2-Hydroxymethylmorpholine-4-carboxylic acid tert-butyl ester (R)-N-BOC-2-HYDROXYMETHYLMORPHOLINE (R)-4-BOC-2-HYDROXYMETHYL-MORPHOLINE (R)-4-t-butoxycarbonyl-2-(hydroxymethyl)morpholine 2-(Hydroxymethyl)morpholine-4-carboxylic acid (R)-tert-butyl ester 4-Morpholinecarboxylic acid, 2-(hydroxyMethyl)-, 1,1-diMethylethyl ester, (2R)- (R)-2-hydroxyMethyl-4-BOC-Morpholine (2R)-2-(Hydroxymethyl)-4-morpholinecarboxylic acid tert-butyl ester (R)-N-Boc-2-hydroxymethylmorpholine,99%e.e. Tert-Butyl(R)-2-(Hydroxymethyl)Morpholine-4-Carboxylate tert-Butyl (2R)-2-(hydroxymethyl)morpholine-4-carboxylate 95+% (R)-N-Boc-2-hydroxymethylmorpholine,99% (R)-N-Boc-2-Hydroxymethylmorpholine ISO 9001：2015 REACH (R)/(S)-N-Boc-2-hydroxymethylmorpholine Evocalcet impurity 36 tert-butyl (2R)-2-(hydroxymethyl)morpholine-4-carboxylate 135065-71-3 pharmacetical