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2,4-Dichlorothieno[2,3-d]pyrimidine

2,4-Dichlorothieno[2,3-d]pyrimidine structure

CAS No.: 18740-39-1

Chemical Name:: 2,4-Dichlorothieno[2,3-d]pyrimidine

Synonyms: 2,4-Dichlorothieno[2,3-d]...;2,4-Dichlorothieno[2,3-d]pyrimidine;Thieno[2,3-d]pyrimidine, 2,4-dichloro-;2,4-Dichlorothieno[2,3-d]pyrimidine ISO 9001：2015 REACH

CBNumber:: CB2958369

Molecular Formula:: C6H2Cl2N2S

Molecular Weight:: 205.06

MDL Number:: MFCD09743991

MOL File:: 18740-39-1.mol

MSDS File:: SDS

Last updated:2026-05-28 00:54:09

Request For Quotation

2,4-Dichlorothieno[2,3-d]pyrimidine Properties

Boiling point	274.8±22.0 °C(Predicted)
Density	1.662±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
pka	-0.84±0.40(Predicted)
form	crystalline powder
color	Pale yellow
InChI	InChI=1S/C6H2Cl2N2S/c7-4-3-1-2-11-5(3)10-6(8)9-4/h1-2H
InChIKey	HRXNGIQKOWQHCX-UHFFFAOYSA-N
SMILES	C1(Cl)=NC(Cl)=C2C=CSC2=N1
UNSPSC Code	12352200
NACRES	NA.21

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS06
Signal word	Danger
Hazard statements	H301-H319
Precautionary statements	P301+P310-P305+P351+P338
Risk Statements	36
Safety Statements	26
RIDADR	2811
HazardClass	6.1
PackingGroup	Ⅲ
HS Code	2934999090
Storage Class	6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects
Hazard Classifications	Acute Tox. 3 Oral Eye Irrit. 2

2,4-Dichlorothieno[2,3-d]pyrimidine price More Price(54)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SYX00043	2,4-Dichlorothieno[2,3-d]pyrimidine Aldrich	18740-39-1	1g	$304	2026-04-30	Buy
AstaTech	50257	2,4-DICHLOROTHIENO[2,3-D]PYRIMIDINE 95%	18740-39-1	1G	$20	2026-04-30	Buy
AstaTech	50257	2,4-DICHLOROTHIENO[2,3-D]PYRIMIDINE 95%	18740-39-1	5G	$66	2026-04-30	Buy
AstaTech	50257	2,4-DICHLOROTHIENO[2,3-D]PYRIMIDINE 95%	18740-39-1	10G	$128	2026-04-30	Buy
Apolloscientific	OR480713	2,4-Dichlorothieno[2,3-d]pyrimidine 98%	18740-39-1	1g	$29	2026-06-04	Buy

Product number	Packaging	Price	Buy
SYX00043	1g	$304	Buy
50257	1G	$20	Buy
50257	5G	$66	Buy
50257	10G	$128	Buy
OR480713	1g	$29	Buy

2,4-Dichlorothieno[2,3-d]pyrimidine Chemical Properties, Uses, Production

Application

2,4-Dichlorothiophene[2,3-D]pyrimidine is an organic intermediate commonly used in the preparation of pharmaceutical products.

Synthesis

18740-38-0

18740-39-1

General procedure for the synthesis of 2,4-dichlorothieno[2,3-d]pyrimidines from 2,4-dihydroxythieno[2,3-d]pyrimidines: thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione (12) (2.5 g, 0.012 mol) and a drop of N,N-dimethylformamide (DMF) were added to 20 mL phosphorus oxychloride (POCl3) . The reaction mixture was heated to 115°C and kept for 8 hours. After the reaction was completed, it was cooled to room temperature and the reaction mixture was slowly poured into 500 g of ice-water mixture. The solid product was collected by filtration and dissolved in dichloromethane (CH2Cl2). The insoluble material was removed by filtration and the filtrate was distilled under reduced pressure to give 1.7 g of 2,4-dichlorothieno[2,3-d]pyrimidine (13) in 56.0% yield. The structure of the product was confirmed by 1H NMR (400 MHz, DMSO-d6) δ 8.16 (d, J = 3.4 Hz, 1H, Ar-H), 7.62 (d, J = 3.4 Hz, 1H, Ar-H) and ESI-MS (m/z): 205.1 [M+H]+.

References

[1] Journal of Medicinal Chemistry, 2011, vol. 54, # 22, p. 7815 - 7833
[2] Bulletin of the Korean Chemical Society, 2010, vol. 31, # 8, p. 2242 - 2246
[3] European Journal of Medicinal Chemistry, 2015, vol. 93, p. 64 - 73
[4] Patent: CN106831812, 2017, A. Location in patent: Paragraph 0091; 0092; 0093
[5] Patent: JP6120311, 2017, B2. Location in patent: Paragraph 0144-0145

2,4-Dichlorothieno[2,3-d]pyrimidine Preparation Products And Raw materials

Raw materials

2,4-Dihydroxythieno[2,3-d]pyrimidine N,N-Dimethylformamide trichlorophosphate

Preparation Products

2,4-Dihydroxythieno[2,3-d]pyrimidine 2-Chloro-4-phenyl-thieno[2,3-d]pyrimidine

2,4-Dichlorothieno[2,3-d]pyrimidine Suppliers

Global Suppliers ( 182)

Supplier	Tel	Email	Country	ProdList	Advantage
Nanjing Habo Medical Technology Co., Ltd.	13376080562 13376090521	sales@habotech.com	China	724	60
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66
JinYan Chemicals(ShangHai) Co.,Ltd.	13817811078	sales@jingyan-chemical.com	China	9963	60
Shanghai Sinch Parmaceuticals Tech. Co. Ltd.	+86-21-54098501	sales@sinch.com.cn	China	11592	64
Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd.	21-57721279 18121011378	sales@shydchem.com.cn	China	998	56
Shangchem Co., Ltd.	+86-21-68182121		China	881	52
Pure Chemistry Scientific Inc.	001-857-928-2050 or 1-888-588-9418	sales@chemreagents.com	United States	10174	62
Accela ChemBio Co.,Ltd.	021-50795510 4000665055	marketing@accelachem.com	China	10972	64
Shanghai Longsheng chemical Co.,Ltd.	58099637 13585536065	sales@shlschem.com	China	9880	59

Supplier	Advantage
Nanjing Habo Medical Technology Co., Ltd.	60
Energy Chemical	61
Capot Chemical Co., Ltd	66
JinYan Chemicals(ShangHai) Co.,Ltd.	60
Shanghai Sinch Parmaceuticals Tech. Co. Ltd.	64
Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd.	56
Shangchem Co., Ltd.	52
Pure Chemistry Scientific Inc.	62
Accela ChemBio Co.,Ltd.	64
Shanghai Longsheng chemical Co.,Ltd.	59

View Latest Price from 2,4-Dichlorothieno[2,3-d]pyrimidine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-06-25	2,4-Dichlorothieno[2,3-d]pyrimidine 18740-39-1	$1.10	1g	99.0% min	100 tons min	Shaanxi Dideu Medichem Co. Ltd
2025-04-04	2,4-Dichlorothieno[2,3-d]pyrimidine 18740-39-1		1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.
2019-07-06	2,4-Dichlorothieno[2,3-d]pyrimidine 18740-39-1	$8.00	1kg	99%	10tons	Career Henan Chemical Co

2,4-Dichlorothieno[2,3-d]pyrimidine
18740-39-1
$1.10
99.0% min
Shaanxi Dideu Medichem Co. Ltd

2,4-Dichlorothieno[2,3-d]pyrimidine
18740-39-1
98%
Henan Aochuang Chemical Co.,Ltd.

2,4-Dichlorothieno[2,3-d]pyrimidine
18740-39-1
$8.00
99%
Career Henan Chemical Co

2,4-Dichlorothieno[2,3-d]pyrimidine Spectrum

2,4-Dichlorothieno[2,3-d]pyrimidine(18740-39-1)¹HNMR 2,4-Dichlorothieno[2,3-d]pyrimidine(18740-39-1)FT-IR

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2,4-Dichlorothieno[2,3-d]pyrimidine 2,4-Dichlorothieno[2,3-d]... Thieno[2,3-d]pyrimidine, 2,4-dichloro- 2,4-Dichlorothieno[2,3-d]pyrimidine ISO 9001：2015 REACH 18740-39-1 Heterocycle-Pyrimidine series Heterocycles series