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Lapatinib ditosylate monohydrate

Lapatinib ditosylate monohydrate Structure
Lapatinib ditosylate monohydrate structure
CAS No.
388082-78-8
Chemical Name:
Lapatinib ditosylate monohydrate
Synonyms
Lapatinib ditosylate Monohydrate;Lapatinib tosilate;Lapatinib ditosylate hydrate;Lapatinb;GW2016 ditosylate;GW-572016;GW572016;(E)-Ferulic acid-d;lapatinib(GW572016);Lapatinib Ditosilate;xyene sulfonate lapatinib
CBNumber:
CB2966227
Molecular Formula:
C41H40ClFN4O11S3
Molecular Weight:
925.46
MDL Number:
MFCD09264195
MOL File:
388082-78-8.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-27 17:00:41
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Lapatinib ditosylate monohydrate Properties

Melting point >200oC (dec.)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
color Yellow
InChIKey UDGDJZMBLIHDBS-UHFFFAOYSA-N
SMILES CS(=O)(=O)CCNCC1=CC=C(O1)C1C(OCC2C=CC=C(F)C=2)=C(Cl)C=C(C=1)NC1=NC=NC2=C1C=CC=C2.C1=C(S(=O)(=O)O)C=CC(C)=C1.C1=C(S(=O)(=O)O)C=CC(C)=C1.O
CAS DataBase Reference 388082-78-8(CAS DataBase Reference)
FDA UNII G873GX646R
NCI Dictionary of Cancer Terms lapatinib ditosylate
NCI Drug Dictionary lapatinib ditosylate

SAFETY

Risk and Safety Statements

Hazard statements  H413

Lapatinib ditosylate monohydrate price More Price(58)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth FL24843 Lapatinib ditosylate monohydrate 388082-78-8 1g $343.75 2026-06-04 Buy
Biosynth FL24843 Lapatinib ditosylate monohydrate 388082-78-8 5g $1237.5 2026-06-04 Buy
Biosynth FL24843 Lapatinib ditosylate monohydrate 388082-78-8 10g $1650 2026-06-04 Buy
ChemScene CS-0008567 Lapatinib ditosylate monohydrate 99.99% 388082-78-8 50mg $65 2026-06-04 Buy
ChemScene CS-0008567 Lapatinib ditosylate monohydrate 99.99% 388082-78-8 100mg $84 2026-06-04 Buy
Product number Packaging Price Buy
FL24843 1g $343.75 Buy
FL24843 5g $1237.5 Buy
FL24843 10g $1650 Buy
CS-0008567 50mg $65 Buy
CS-0008567 100mg $84 Buy

Lapatinib ditosylate monohydrate Chemical Properties, Uses, Production

Uses

anticancer

Uses

binds to a(1), dopamine, histamine H1, muscarinic, and serotonin type 2 (5-HT2) receptors atypical antipsychotic agent

Uses

Lapatinib ditosylate monohydrate is a form of Lapatinib I, an orally active drug for breast cancer as a dual EGFR and erbB-2 inhibitor.

Definition

ChEBI: Lapatinib ditosylate monohydrate is a member of quinazolines.

General Description

Lapatinib is available in 250-mg tablets for oral administrationand is used in combination with cabecitabine in thetreatment of breast cancer for those patients that over expressthe type 2 EGF-R and who have previously receivedtaxane, anthracycline, and trastuzumab therapy. The type 2EGF-R is one subtype of this receptor and is also known asHER2 or ErbB-2. The agent is a receptor TK inhibitor targetingthe ErbB-1 and ErbB-2 subtypes. Binding occurs atthe ATP-binding site and thereby prevents phosphorylationand the subsequent activation of other kinase enzymes.ErbB-1 overexpression occurs in approximately27% to 30% of breast cancers, while ErbB-2 is over expressedin 20% to 25% of cases.The agent has demonstratedIC50 values of ＜0.2μM against ErbB-1 and 2 fromseveral different cancer cell lines and dissociates slowly(t1/2＝300 min) from these receptor TKs.The drug isboth a substrate and an inhibitor of the efflux transportersPgp and BCRP. It is also an inhibitor of the hepatic uptaketransporter OATP1B1, which is an organic anion transporter.The absorption of lapatinib is incomplete andvariable after oral administration. The agent is extensivelymetabolized by CYP3A4 and CYP3A5, with minor contributionsfrom CYP2C19 and CYP2C8. Lapatinib inhibitsCYP3A and CYP2C8 at clinically relevant concentrations.The agent is highly (99%) protein bound and eliminatedprimarily in the feces. The half-life of the agent increaseupon repeated dosing, taking 6 days to reach steady statethat gives an effective half-life of 24 hours. The most commonlyseen adverse effects of lapatinib therapy are skinrash and diarrhea. Skin rash is commonly seen with manyof the other TK inhibitors and agents that target ErbB-1.Lapatinib-induced diarrhea is usually mild to moderate.There have been reports of decreases in left ventricularejection fraction associated with the agent, although thisappears to occur only rarely and is reversible upon discontinuationof therapy.

target

EGFR

Lapatinib ditosylate monohydrate synthesis

49773-20-8
104-15-4
231278-84-5
388082-78-8
Synthesis of Lapatinib ditosylate monohydrate from 2-Aminoethylmethyl sulfone and p-Toluenesulfonic acid and 5-[4-((3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)quinazolin-6-yl]-2-furaldehyde

Lapatinib ditosylate monohydrate Preparation Products And Raw materials

Raw materials

5-[4-((3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)quinazolin-6-yl]-2-furaldehyde 2-Aminoethylmethylsulfone hydrochloride 2-Aminoethylmethyl sulfone p-Toluenesulfonic acid

Preparation Products

Lapatinib

Lapatinib ditosylate monohydrate Suppliers

Global Suppliers ( 389)
Supplier Tel Email Country ProdList Advantage
Jinan Yuantai Pharmaceutical Co.,Ltd 0531-69959492 18560053868 85349064@qq.com China 144 58
HONEST PHARM CO.,LTD. 0531-59840128 19353175568 zpy8217@163.com China 432 58
Eastchem Technology Co., Ltd 18726868929 sales@eastchetech.com China 17 58
Jinan Hanyu Chemical Co., Ltd 0531-69954981 15666777973 sales@hanyuchem.com China 23 58
Jinan Sunshine Pharmaceutical Co.,Ltd. 531-82812892 18668915976 sales@sunshinepharm.com.cn China 28 58
Shanghai Boyle Chemical Co., Ltd. sales@boylechem.com China 2915 55
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Chembest Research Laboratories Limited 021-20908456 sales@BioChemBest.com China 5996 61
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Jia Xing Isenchem Co.,Ltd 0573-85285100 18627885956 isenchem@163.com China 9389 66
Supplier Advantage
Jinan Yuantai Pharmaceutical Co.,Ltd 58
HONEST PHARM CO.,LTD. 58
Eastchem Technology Co., Ltd 58
Jinan Hanyu Chemical Co., Ltd 58
Jinan Sunshine Pharmaceutical Co.,Ltd. 58
Shanghai Boyle Chemical Co., Ltd. 55
J & K SCIENTIFIC LTD. 76
Chembest Research Laboratories Limited 61
Capot Chemical Co., Ltd 66
Jia Xing Isenchem Co.,Ltd 66

View Latest Price from Lapatinib ditosylate monohydrate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Lapatinib ditosylate pictures 2026-09-18 Lapatinib ditosylate
388082-78-8
 1KG 99%min 1000G WUHAN FORTUNA CHEMICAL CO., LTD
Lapatinib ditosylate pictures 2026-09-18 Lapatinib ditosylate
388082-78-8
 0.99 RongNa Biotechnology Co.,Ltd
Lapatinib Ditosylate pictures 2026-09-18 Lapatinib Ditosylate
388082-78-8
 1g More Than 99% 100kg/Month BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.

Lapatinib ditosylate monohydrate Spectrum

Lapatinib ditosylate monohydrate(388082-78-8)1HNMR

388082-78-8 (Lapatinib ditosylate monohydrate) Related Search:

Lapatinib Penta(ethylene glycol) di-p-toluenesulfonate Afatinib dimaleate Pazopanib Osimertinib mesylate
Baricitinib Afatinib Regorafenib monohydrate Cabazitaxel Pazopanib Hydrochloride
Regorafenib AZD-9291 Nintedanib esylate 2-mercapto-N-methylbenzamide N-[3-Chloro-4-(3-fluorobenzyloxy)phenyl]-6-iodoquinazolin-4-amine
5-[4-((3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)quinazolin-6-yl]-2-furaldehyde 2-Aminoethylmethylsulfone hydrochloride p-Toluenesulfonic acid

1of4

benzenesulfonic acid: N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6 -[5-[(2-methylsulfonylethylamino)methyl]-2-furyl]quinazolin-4-amine: h ydrate N-(3-Chloro-4-((3-fluorophenyl)methoxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)-2-furanyl)-4-quinazolinamine bis(4-methylbenzenesulfonate) Lapatinib Ditosilate Lapatinib, Tykerb, GW572016 Lapatinib Ditosylate (GW-572016) lapatinib(GW572016) Lapatinib ditosylate hydrate bis(N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-(5-((2-(Methylsulfonyl)ethylaMino)Methyl)furan-2-yl)quinazolin-4-aMine) tetrakis(4-Methylbenzenesulfonate) hydrate Lapatinb 4-QuinazolinaMine, N-[3-chloro-4-[(3-fluorophenyl)Methoxy]phenyl]-6-[5-[[[2-(Methylsulfonyl)ethyl]aMino]Methyl]-2-furanyl]-, bis(4-Methylbenzenesulfonate), Monohydrate (9CI) Lapatinib ditosylate Monohydrate Rapatinib bis - toluene sulfonate GW-572016;GW572016 Lapatinib xylene sulfonate N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-4-quinazolinamine, 4-methylbenzenesulfonate, hydrate (1:2:1) Lapatinib Ditosylate MonohydrateI N-(3-Chloro-4-((3-fluorophenyl)methoxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)-2-furanyl)-4-quinazolinamine bis(4-methylbenzenesulfonate) monohydrate Lapatinib ditosylate hydrat 4-QuinazolinaMine, N-[3-chloro-4-[(3-fluorophenyl)Methoxy]phenyl]-6-[5-[[[2-(Methylsulfonyl)ethyl]aMino]Methyl]-2-furanyl]-, bis(4-Methylbenzenesulfonate), Monohydrate xyene sulfonate lapatinib (N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-(5-((2-(Methylsulfonyl)ethylaMino)Methyl)furan-2-yl)quinazolin-4-aMine)bis(4-Methylbenzenesulfonate) hydrate Lapatinib ditosylate N-(3-Chloro-4-((3-fluorophenyl)methoxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)-2-furanyl)-4-quinazolinamine bis(4-methylbenzenesulfonate) N-(3-Chloro-4-(3-fluorobenzyloxy)phenyl)-6-(5-((2-(methylsulfonyl)ethylamino)methyl)furan-2-yl)-quinazolin-4-ylamine ditosylate hydrate Lapatinib ditoluenesulfonate monohydrate Lapatinib tosilate Lapatinib tosilate hydrate Lapatinib ditosylate ISO 9001：2015 REACH Lapatinib D4 DitosylateQ: What is Lapatinib D4 Ditosylate Q: What is the CAS Number of Lapatinib D4 Ditosylate Lapatinib p-toluenesulfonate monohydrate GW2016 ditosylate (E)-Ferulic acid-d Lapatinib ditosylate monohydrate|||Lapatinib ditoluenesulfonate monohydrate|||Lapatinib tosilate hydrate|||Lapatinib tosilate|||Tykerb|||Tyverb Lapatinib ditosylate monohydrate, 10 mM in DMSO 388082-78-8 388083-78-8 388082-78-9 C29H26ClFN4O4S2C7H8O3 C29H26ClFN4O4S2C7H8O3S C41H40ClFN4O11S3 C29H26ClFN4O4S2C74H8O3SH2O 2C7H8O3SC29H26ClFN4O4S C29H26ClFN4O4S2C7H8O3SH2O C43H44ClFN4O11S3 anti-neoplastic Inhibitors Anti-cancer&immunity Lapatinib API 388082-78-8