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Pazopanib Hydrochloride

Pazopanib Hydrochloride Structure
Pazopanib Hydrochloride structure
CAS No.
635702-64-6
Chemical Name:
Pazopanib Hydrochloride
Synonyms
Pazopanib HCl;Pazopanib hydrochloride;Pazopanib HCI;CS-462;ArMala;786034;GW-786034B;GW786034 HCl;Votrient HCl;Unii-33Y9anm545
CBNumber:
CB42495435
Molecular Formula:
C21H24ClN7O2S
Molecular Weight:
473.98
MDL Number:
MFCD12546138
MOL File:
635702-64-6.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-27 17:00:41
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Pazopanib Hydrochloride Properties

Melting point >290°C (dec.)
storage temp. Hygroscopic, Refrigerator, under inert atmosphere
solubility Acetonitrile (Slightly), DMSO (Slightly)
form Yellow powder.
color White to Off-White
Stability Hygroscopic
InChIKey MQHIQUBXFFAOMK-UHFFFAOYSA-N
SMILES CC1N(N=C2C=C(N(C3C=CN=C(NC4C=CC(C)=C(S(=O)(=O)N)C=4)N=3)C)C=CC=12)C.Cl
NCI Dictionary of Cancer Terms pazopanib hydrochloride
FDA UNII 33Y9ANM545
NCI Drug Dictionary pazopanib hydrochloride

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H332-H335
Precautionary statements  P261-P280-P305+P351+P338

Pazopanib Hydrochloride price More Price(91)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML3076 Pazopanib hydrochloride ≥98% (HPLC) 1149669-28-2 10 mg $96.8 2025-07-31 Buy
Sigma-Aldrich SML3076 Pazopanib hydrochloride ≥98% (HPLC) 1149669-28-2 50 mg $315 2025-07-31 Buy
Sigma-Aldrich SML3076 Pazopanib hydrochloride ≥98% (HPLC) 1149669-28-2 10MG $86.1 2022-05-15 Buy
Sigma-Aldrich SML3076 Pazopanib hydrochloride ≥98% (HPLC) 1149669-28-2 50MG $348 2022-05-15 Buy
TCI Chemical P2243 Pazopanib Hydrochloride 635702-64-6 50MG $60 2026-04-30 Buy
Product number Packaging Price Buy
SML3076 10 mg $96.8 Buy
SML3076 50 mg $315 Buy
SML3076 10MG $86.1 Buy
SML3076 50MG $348 Buy
P2243 50MG $60 Buy

Pazopanib Hydrochloride Chemical Properties, Uses, Production

Description

Pazopanib Hydrochloride is the hydrochloride salt of a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is an oral second-generation multitarget TKI developed by GSK and approved for marketing by the FDA in 2009 and the EMA in 2010. It targets the VEGFR, platelet-derived growth factor receptor, and c-kit, key proteins responsible for tumor growth and survival. It is used to treat patients with advanced RCC and advanced soft tissue sarcoma who have experienced chemotherapy. Pazopanib Hydrochloride has a role as an antineoplastic agent, a vascular endothelial growth factor receptor antagonist, a tyrosine kinase inhibitor, and an angiogenesis-modulating agent.

Originator

GlaxoSmithKline (US)

Uses

Pazopanib Hydrochloride (GW786034) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit and c-Fms with IC50 of 10 nM, 30 nM, 47 nM, 84 nM, 74 nM, 140 nM and 146 nM, respectively - See more at: http://www.selleckchem.com/products/Pazopanib-Hyd

Definition

Pazopanib Hydrochloride is used for treatment of kidney cancer. Pazopanib is the latest VEGFR kinase inhibitor to reach the market. It is indicated for the oral treatment of advanced RCC. The biological functions of the VEGF family are mediated by activation of three structurally homologous tyrosine kinase receptors, VEGFR-1, VEGFR-2, and VEGFR3. 

brand name

Votrient

Clinical Use

Pazopanib is a potent and selective multi-targeted receptor tyrosine kinase inhibitor of VEGFR-1, VEGFR-2, VEGFR-3, PDGFR-a/b, and c-kit that blocks tumor growth and inhibits angiogenesis. It was approved for renal cell carcinoma by the U.S. Food and Drug Administration in 2009 and is marketed under the trade name Votrient by the drug’s manufacturer, GlaxoSmithKline.

Side effects

Pazopanib is synthesized in five chemical steps starting from 3-methyl-6-nitroindazole, which is converted to the corresponding 2,3-dimethylindazole analog via N-methylation with trimethyloxonium tetrafluoroborate. Subsequent reduction of the nitro group to the amino group using tin chloride followed by condensation with 2,4dichloropyrimidine yields a chloropyrimidinylaminoindazole intermediate. The final two steps leading up to pazopanib consist of an N-methylation reaction using iodomethane and cesium carbonate followed by condensation with 5-amino-2-methylbenzenesulfonamide.

Synthesis

The synthesis of pazopanib begins with methylation of 3-methyl-6- nitroindazole (82) with trimethyl orthoformate in the presence of BF3¤OEt to give indazole 83 in 65% yield. Reduction of the nitro group was achieved via transfer hydrogenation to give 84 in 97% yield, and this was followed by coupling the aniline with 2,4-dichloropyrimidine in a THF-ethanol mixture at elevated temperature to provide diarylamine 85 in 90% yield. The aniline nitrogen was then methylated using methyl iodide to give 86 in 83% yield prior to coupling with 5-amino-2-methylbenzenesulfonamide (87) and salt formation using an alcoholic solution of HCl to furnish pazopanib hydrochloride (XIV) in 81% yield.

Synthesis_635702-64-6

target

VEGFR1

References

[1] Sodeifian, G. et al. “Solubility of pazopanib hydrochloride (PZH, anticancer drug) in supercritical CO2: Experimental and thermodynamic modeling.” The Journal of Supercritical Fluids 55 1 (2022): 0.
[2] “Stability Indicating HPTLC Method Development and Validation for the Estimation of Pazopanib Hydrochloride in Bulk and its Dosage Form.” International Journal of Pharmaceutical Research 18 1 (2020).
[3] K. Kawasaki . “Retrospective Safety Analysis in Advanced Soft Tissue Sarcoma Patients of Pazopanib Hydrochloride.” Annals of Oncology 24 (2013): Page ix38.
[4] Gupta, Amit and Rashmi Dahima. “Application of Simplex Lattice Mixture design and desirability function in the development and Optimization of SEDDS for protein kinase inhibitor-Pazopanib Hydrochloride.” Research Journal of Pharmacy and Technology 83 1 (2023): 0.

Pazopanib Hydrochloride Preparation Products And Raw materials

Raw materials

3-Methyl-6-nitroindazole 5-Amino-2-methylbenzenesulfonamide

Preparation Products

Pazopanib Hydrochloride Suppliers

Global Suppliers ( 381)
Supplier Tel Email Country ProdList Advantage
Yangzhou QinYuan Pharmaceutical Co., Ltd. 0514-80939770 13773367191 yzqyyykj@163.com China 253 55
Taizhou Ruixin Chemical Co., Ltd. 0576-89085261 15867635987 jasonhu09@163.com China 439 50
Jiaxing Triview Biochemical Products Co., Ltd. 0573-0573-87228088 17772796899 triview@triviewbiochem.com China 17 58
Shanghai Runtai Pharmaceutical Technology Co., LTD 152-6236-2504 18019700392 clong008@163.com China 117 58
Suzhou ARTK Medchem Co., Ltd. 18168183658 sales1@artkmedchem.com China 782 58
Shandong Xindao Pharmaceutical Technology Co.,Ltd 0546-5612566 18019700392 3625645361@qq.com China 60 58
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd 4000862158 18117107507 vip@med-life.cn China 4999 58
Fujian Huayao Pharmaceutical Technology Co., Ltd. 18559985626 liujie@fjhypharma.com China 18 58
Shanghai Boyle Chemical Co., Ltd. sales@boylechem.com China 2915 55
Chembest Research Laboratories Limited 021-20908456 sales@BioChemBest.com China 5996 61
Supplier Advantage
Yangzhou QinYuan Pharmaceutical Co., Ltd. 55
Taizhou Ruixin Chemical Co., Ltd. 50
Jiaxing Triview Biochemical Products Co., Ltd. 58
Shanghai Runtai Pharmaceutical Technology Co., LTD 58
Suzhou ARTK Medchem Co., Ltd. 58
Shandong Xindao Pharmaceutical Technology Co.,Ltd 58
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd 58
Fujian Huayao Pharmaceutical Technology Co., Ltd. 58
Shanghai Boyle Chemical Co., Ltd. 55
Chembest Research Laboratories Limited 61

Related articles

View Latest Price from Pazopanib Hydrochloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Pazopanib Hydrochlorid pictures 2026-09-18 Pazopanib Hydrochlorid
635702-64-6
 1g More Than 99% 100kg/Month BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
Pazopanib Hydrochloride pictures 2026-09-18 Pazopanib Hydrochloride
635702-64-6
 1g More Than 99% 50kg/Month BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
GW786034B pictures 2026-07-27 GW786034B
635702-64-6
 $37.00-97.00 99.87% 10g TargetMol Chemicals Inc.
  • GW786034B pictures
  • GW786034B
    635702-64-6
  • $37.00-97.00
  • 99.87%
  • TargetMol Chemicals Inc.

Pazopanib Hydrochloride Spectrum

Unii-33Y9anm545(635702-64-6)1HNMR

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Pazopanib hydrochloride Unii-33Y9anm545 BenzenesulfonaMide, 5-[[4-[(2,3-diMethyl-2H-indazol-6-yl)MethylaMino]-2-pyriMidinyl]aMino]-2-Methyl-, hydrochloride 786034 ArMala Pazopanib Hydrochloride (GW786034) 5-(4-((2,3-diMethyl-2H-indazol-6-yl)(Methyl)aMino)pyriMidin-2-ylaMino)-2-MethylbenzenesulfonaMide hydrochloride GW786034 (Hydrochloride)) 5-[[4-[(2,3-dimethylindazol-6-yl)-methylamino]pyrimidin-2-yl]amino]-2-methylbenzenesulfonamide,hydrochloride CS-462 GW-786034B GW-786034;GW786034;GW 786034 Pazopanib HCl (GW786034 HCl) Pazopanib HCl (GW786034) 5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide HCl Pazopanib HCl API Pazopanib HCl, >=99% 5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidin-yl]amino]-2-methylbenzenesulfonamide monohydrochloride Pazopanib hydrochloride(API) GW786034 HCl Votrient HCl Unii-33Y9anm545 USP/EP/BP Unii-33Y9anm545 635702-64-6 Pazoni hydrochloride 5-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl}amino)-2-methylbenzene-1-sulfonamide hydrochloride 5- (4- ((2,3-dimethyl-2H-indole-6-yl) (methyl) amino) pyrimidin-2-yl) amino) -2-methylbenzenesulfonamide hydrochloride Pazopanil hydrochloride Pazopanib Hydrochlorid Mosapride Impurity 2 Hydrochloride Pazopanib Hydrochloride, 10 mM in DMSO PAZOPANIB HCL (NON-STERILE DRUG SUBSTANCE) Pezopanib hydrochloride Pazopanib HCl - Bio-X ? 5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)(methyl)amino]-2-pyrimidinyl]amino]-2-methylbenzenesulfonamide Hydrochloride Pazopanib HCI Pazopanib HCl 635702-64-6 C21H23N7O2SHCl C21H24ClN7O2S C21H23N7O2SClH HFC80011 API