Penta(ethylene glycol) di-p-toluenesulfonate
- CAS No.
- 41024-91-3
- Chemical Name:
- Penta(ethylene glycol) di-p-toluenesulfonate
- Synonyms
- TSO-PEG5-OTS;PENTAETHYLENE GLYCOL DITOSYLATE;NSC625453;Tos-PEG6-Tos;Bis-Tos-PEG5;Pentaethylene glycol di(p<;METHYL 3-(BENZYLTHIO)ISOPROPIONATE;PENTA(ETHYLENE GLYCOL)DI-P-TOSYLATE;PENTAETHYLENE GLYCOL DI-P-TOLUENESULPHONATE;Pentaethyleneglycoldi-p-toluenesulfonate,98%
- CBNumber:
- CB3189173
- Molecular Formula:
- C24H34O10S2
- Molecular Weight:
- 546.65
- MDL Number:
- MFCD00012204
- MOL File:
- 41024-91-3.mol
- MSDS File:
- SDS
| Boiling point | 661.4±55.0 °C(Predicted) |
|---|---|
| Density | 1.26 g/mL at 25 °C (lit.) |
| refractive index |
n |
| Flash point | >230 °F |
| storage temp. | Storage temp. 2-8°C |
| form | Solid-Liquid Mixture |
| color | Off-white to light brown |
| Water Solubility | Not miscible or difficult to mix in water. |
| Sensitive | Hygroscopic |
| BRN | 3599245 |
| InChI | InChI=1S/C24H34O10S2/c1-21-3-7-23(8-4-21)35(25,26)33-19-17-31-15-13-29-11-12-30-14-16-32-18-20-34-36(27,28)24-9-5-22(2)6-10-24/h3-10H,11-20H2,1-2H3 |
| InChIKey | BUHGDYPBQWWWQS-UHFFFAOYSA-N |
| SMILES | C(OS(C1=CC=C(C)C=C1)(=O)=O)COCCOCCOCCOCCOS(C1=CC=C(C)C=C1)(=O)=O |
| FDA UNII | 7STJ9FM34S |
| EPA Substance Registry System | 3,6,9,12-Tetraoxatetradecane-1,14-diol, bis(4-methylbenzenesulfonate) (41024-91-3) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | Eyeshields, Gloves, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| Storage Class | 10 - Combustible liquids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
Penta(ethylene glycol) di-p-toluenesulfonate price More Price(42)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 309583 | Pentaethylene glycol di(p-toluenesulfonate) 95% | 41024-91-3 | 5g | $94.8 | 2026-04-30 | Buy |
| Sigma-Aldrich | 309583 | Pentaethylene glycol di(p-toluenesulfonate) 95% | 41024-91-3 | 25g | $394 | 2023-06-20 | Buy |
| ChemScene | CS-W004447 | Pentaethylene glycol di(p-toluenesulfonate) ≥96% | 41024-91-3 | 5g | $25 | 2026-06-04 | Buy |
| ChemScene | CS-W004447 | Pentaethylene glycol di(p-toluenesulfonate) ≥96% | 41024-91-3 | 10g | $49 | 2026-06-04 | Buy |
| ChemScene | CS-W004447 | Pentaethylene glycol di(p-toluenesulfonate) ≥96% | 41024-91-3 | 25g | $116 | 2026-06-04 | Buy |
Penta(ethylene glycol) di-p-toluenesulfonate Chemical Properties, Uses, Production
Description
Tos-PEG6-Tos is a PEG linker containing two tosyl groups. The hydrophilic PEG spacer increases solubility in aqueous media. The tosyl group is a very good leaving group for nucleophilic substitution reactions.
Uses
PENTA(ETHYLENE GLYCOL) DI-P-TOLUENESULFONATE is used to prepare calix[4]arenes,1 calix[5]arenes,2 and crown ethers.3
Uses
Pentaethylene glycol di-p-toluenesulfonate is used in the preparation of calix[4]arenes, calix[5]arenes, and crown ethers. It is also used in the preparation of 3-formylbenzo-18-crown-6 by undergoing coupling reaction with 2,3-dihydroxybenzaldehyde.
Synthesis
4792-15-8
98-59-9
41024-91-3
Pentaethylene glycol (10.8 g, 57.8 mmol) was slowly added to a stirred mixture of potassium hydroxide (7.8 g, 139.3 mmol) and ethylene glycol (60 mL) under nitrogen protection and the reaction was carried out at room temperature. Subsequently, the reaction mixture was heated to reflux temperature and stirred continuously for 36 hours. Upon completion of the reaction, it was cooled to room temperature, the reaction mixture was filtered and concentrated by depressurization to obtain a viscous oily substance. This viscous oily substance was dissolved with sodium hydroxide (4.8 g, 120 mmol) in a solution of tetrahydrofuran/water (v/v = 1/1, 40 mL) and cooled under nitrogen protection to 0°C. At this temperature, p-toluenesulfonyl chloride (22 g, 115 mmol) was slowly added. After addition, stirring was continued for 3 hours. At the end of the reaction, water (100 mL) was added to dilute the reaction mixture and the product was extracted with dichloromethane (20 mL × 3). The organic phase was washed with brine (20 mL × 3), and the combined organic layers were dried with anhydrous magnesium sulfate, followed by evaporation to remove the dichloromethane. The crude product was purified by column chromatography (petroleum ether:ethyl acetate = 3:1) to give a yellow oily pure product (8.1 g) in 27.5% yield. The product was characterized by 1H NMR (CDCl3, 500 MHz) with chemical shifts of δ 2.44 (3H, s), 3.57 (4H, s), 3.59 (2H, s), 3.67 (2H, t, J = 4.8 Hz), 4.14 (2H, t, J = 4.8 Hz), 7.33 (2H, d, J = 8.1 Hz), 7.78 (2H, d , J = 8.2 Hz).
References
[1] Bioorganic and Medicinal Chemistry, 2007, vol. 15, # 14, p. 4841 - 4856
[2] Journal of Organic Chemistry, 1999, vol. 64, # 18, p. 6870 - 6873
[3] Canadian Journal of Chemistry, 2006, vol. 84, # 10, p. 1273 - 1279
[4] Collection of Czechoslovak Chemical Communications, 1987, vol. 52, # 8, p. 2057 - 2060
[5] Russian Journal of Organic Chemistry, 2012, vol. 48, # 10, p. 1345 - 1352
Penta(ethylene glycol) di-p-toluenesulfonate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Chiral bio-compound co., Ltd. | 021-5068 3667/17749785980/1029026415; 17749785980 | 1029026415@qq.com | China | 4501 | 58 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Shanghai Jian Chao Chemical Technology Co., Ltd. | 150-2103-5486 18017383231 | 983544897@qq.com | China | 9335 | 55 |
| Nanjing Junnahe Biopharmaceutical Co., Ltd | 025-58367986 17351780683 | amy.xiang@ally-chem.com | China | 354 | 60 |
| Shanghai Raise Chemical Technology Co.,Ltd | 15026594951 | rs@raise-chem.com | China | 4904 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| ShangHai D&B Biological Science and Technology Co.Ltd | 400-008-9730,021-54359730 400-008-9730 | info@chemxyz.com | China | 3642 | 60 |
| Shanghai Xingui Biotechnology Co., Ltd. | 15121041756 | xingui2022@126.com | China | 9954 | 58 |
View Latest Price from Penta(ethylene glycol) di-p-toluenesulfonate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-06-07 | Tos-PEG6-Tos
41024-91-3
|
100g | >98.00% | 100g | Xian confluore Biological Technology Co., Ltd. |
-
- Tos-PEG6-Tos
41024-91-3
- $0.00
- >98.00%
- Xian confluore Biological Technology Co., Ltd.
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