7-Acetyl-2,3-dihydrobenzofuran
- CAS No.
- 170730-06-0
- Chemical Name:
- 7-Acetyl-2,3-dihydrobenzofuran
- Synonyms
- 7-Acetyl-2,3-dihydrobenzofuran;1-(2,3-Dihydro-7-benzofuranyl);1-(2,3-dihydrobenzofuran-7-yl)ethanone;1-(2,3-Dihydro-7-benzofuranyl)ethanone;Ethanone, 1-(2,3-dihydro-7-benzofuranyl);1-(2,3-dihydro-1-benzofuran-7-yl)ethanone;Ethanone, 1-(2,3-dihydro-7-benzofuranyl)- (9CI)
- CBNumber:
- CB2966535
- Molecular Formula:
- C10H10O2
- Molecular Weight:
- 162.19
- MDL Number:
- MFCD11656624
- MOL File:
- 170730-06-0.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
7-Acetyl-2,3-dihydrobenzofuran price More Price(37)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 407643 | 1-(2,3-Dihydro-7-benzofuranyl)ethanone | 170730-06-0 | 100mg | $389 | 2026-06-03 | Buy |
| Usbiological | 407643 | 1-(2,3-Dihydro-7-benzofuranyl)ethanone | 170730-06-0 | 250mg | $602 | 2026-06-03 | Buy |
| Matrix Scientific | 304930 | 1-(2,3-Dihydro-7-benzofuranyl)ethanone | 170730-06-0 | 250.00mg | $49 | 2026-05-19 | Buy |
| Matrix Scientific | 304930 | 1-(2,3-Dihydro-7-benzofuranyl)ethanone | 170730-06-0 | 1.00g | $115 | 2026-05-19 | Buy |
| Matrix Scientific | 304930 | 1-(2,3-Dihydro-7-benzofuranyl)ethanone | 170730-06-0 | 5.00g | $380 | 2026-05-19 | Buy |
7-Acetyl-2,3-dihydrobenzofuran Chemical Properties, Uses, Production
Uses
1-(2,3-Dihydro-7-benzofuranyl)ethanone is an impurity in the synthesis of Darifenacin (D193400, HBr); a medication used to treat urinary incontinence. It works by blocking the M3 muscarinic acetylcholine receptor.
Synthesis
1037763-65-7
75-16-1
170730-06-0
General procedure: N-methoxy-N-methyl-2,3-dihydrobenzofuran-7-carboxylate 1b (10.9 g, 52.65 mmol) was dissolved in 150 mL of anhydrous tetrahydrofuran and degassed three times under argon protection. Subsequently, methylmagnesium bromide solution (35 mL, 3.0 M in diethyl ether, 105 mmol) was slowly added dropwise and the reaction was stirred at room temperature for 1 h to ensure complete reaction. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure. The pH was adjusted to 3-4 by slow dropwise addition of 1 M hydrochloric acid solution to the residue. extraction was carried out with ethyl acetate (30 mL x 4), the organic phases were combined and washed with saturated sodium chloride solution. The organic layer was dried with anhydrous magnesium sulfate, filtered and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography with gradient elution using elution system B. The target product 1-(2,3-dihydrobenzofuran-7-yl)ethanone 1c (6.218 g, light yellow solid) was obtained in 73.1% yield.
References
[1] Patent: CN103382206, 2016, B. Location in patent: Paragraph 0176-0179; 0184-0186
7-Acetyl-2,3-dihydrobenzofuran Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Wulechem Co., Ltd. | 13761914825 | wulesian@wulechem.com | China | 285 | 58 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Tianjin Derchemist Science & Technology Co., Ltd. | 22-58627059 13920586291 | zdcomcon@126.com | China | 4094 | 50 |
| SynAsst Chemical. | 021-60343070 | China | 12731 | 55 | |
| HBCChem, Inc. | +1-510-219-6317 | sales@hbcchem.com | United States | 10628 | 60 |
| Nanjing Chempioneer Pharmaceutical Co., Ltd. | 18068075658 | sales@chempioneer.com | China | 1803 | 58 |
| parabiochem | 025-83453382-8005 | sale@parabiochem.com | China | 9577 | 55 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Aikon International Limited | 025-58859352 19370895928 | sales01@aikonchem.com | China | 15078 | 58 |
| Shanghai Medicil Biomedical Co., Ltd. | 021-50822001 | marketing@medicilon.com.cn | China | 1151 | 58 |
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