2,3-Dihydrobenzofuran
- CAS No.
- 496-16-2
- Chemical Name:
- 2,3-Dihydrobenzofuran
- Synonyms
- COUMARAN;Dihydrobenzofuran;Benzofuran,2,3-dihydro-;2,3-Dihydro-1-benzofuran;Kumaran;Cumaran;Dihydrocoumarone;BUTTPARK 44\01-23;Benzodihydrofuran;3-Dihydrobenzofuran
- CBNumber:
- CB6272979
- Molecular Formula:
- C8H8O
- Molecular Weight:
- 120.15
- MDL Number:
- MFCD00005855
- MOL File:
- 496-16-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | -21°C |
|---|---|
| Boiling point | 188-189 °C (lit.) |
| Density | 1.065 g/mL at 25 °C (lit.) |
| refractive index |
n |
| Flash point | 152 °F |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | alcohol: soluble |
| form | clear liquid |
| Specific Gravity | 1.065 |
| color | Colorless to Yellow to Green |
| Merck | 14,2559 |
| BRN | 111928 |
| InChI | 1S/C8H8O/c1-2-4-8-7(3-1)5-6-9-8/h1-4H,5-6H2 |
| InChIKey | HBEDSQVIWPRPAY-UHFFFAOYSA-N |
| SMILES | C1Cc2ccccc2O1 |
| LogP | 2.140 |
| CAS DataBase Reference | 496-16-2(CAS DataBase Reference) |
| FDA UNII | 99E861415L |
| NIST Chemistry Reference | Benzofuran, 2,3-dihydro-(496-16-2) |
| EPA Substance Registry System | Coumaran (496-16-2) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H227 | |||||||||
| Precautionary statements | P210-P280-P370+P378-P403+P235-P501-P210e-P280a-P370+P378a-P501a | |||||||||
| PPE | Eyeshields, Gloves, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 23-24/25-26 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 29329995 | |||||||||
| Storage Class | 10 - Combustible liquids | |||||||||
| REACH Registrations | Inactive | |||||||||
| NFPA 704 |
|
2,3-Dihydrobenzofuran price More Price(87)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 183962 | 2,3-Dihydrobenzofuran 99% | 496-16-2 | 5g | $70.1 | 2026-04-30 | Buy |
| Sigma-Aldrich | 183962 | 2,3-Dihydrobenzofuran 99% | 496-16-2 | 25g | $141 | 2026-04-30 | Buy |
| TCI Chemical | D1583 | 2,3-Dihydrobenzofuran >98.0%(GC) | 496-16-2 | 5g | $35 | 2026-04-30 | Buy |
| TCI Chemical | D1583 | 2,3-Dihydrobenzofuran >98.0%(GC) | 496-16-2 | 25g | $112 | 2026-04-30 | Buy |
| Cayman Chemical | 39945 | 2,3-Dihydrobenzofuran ≥98% | 496-16-2 | 5g | $40 | 2026-04-30 | Buy |
2,3-Dihydrobenzofuran Chemical Properties,Uses,Production
Chemical Properties
Colorless to light yellow liqui
Uses
2,3-dihydrobenzofuran is widely used in the synthesis of tricyclic compounds and is also an intermediate raw material for the synthesis of some important drugs. It is used in the synthesis of antitumor agents benzofuran sulfonylureas, HIV protease inhibitor amino acid hydroxyethylenesulfonyl, matrix metalloproteinase inhibitor aryl sulfinyl isoxime hydroxamic acid, etc.
Definition
ChEBI: 2,3-dihydrobenzofuran is a member of the class of 1-benzofurans that is the 2,3-dihydroderivative of benzofuran. It has a role as a metabolite.
General Description
Biotransformation of 2,3-dihydrobenzofuran using intact cells of Pseudomonas putida UV4 has been investigated. 2,3-Dihydrobenzofuran is the intermediate formed during catalytic hydrodeoxygenation of benzofuran.
Synthesis
Step 1: Synthesis of 2-phenoxyethanol
Add 200 ml of anhydrous ethanol to a 10000 m L three-necked round-bottomed flask, dissolve sodium metal (23 g) in it, then add phenol (94 g, 900 mL), 2-chloroethanol (700 mL) , respectively, and heat and reflux until the reaction mixture is neutral. The reaction was tracked by running a plate during the reaction (unfolding agent: chloroform:methanol:benzene=200:1:1 ; Rf=0.3). Ethanol was removed by distillation under reduced pressure with a rotary evaporator, and 500 mL of distilled water was added. It was then extracted with ether three times (about 400 mL each time) and washed several times with dilute sodium hydroxide solution and distilled water respectively (to remove phenol). The ether was then removed by distillation at atmospheric pressure, and the residue was distilled under reduced pressure to collect a fraction of 163-166°C (18 mmHg) was obtained. The ether is a colorless thick liquid, bp : 240-246°C, refractive index: 1.532, d:1.1002, insoluble in water but soluble in ether and alcohol (yield: 75 %).
Step 2: Synthesis of 2,3-dihydrobenzofuran
To a 250 mL three-necked round-bottomed flask, 2-phenoxyethanol (50 g) and zinc chloride (5 g) were added and heated to 225°C reflux with mixing and stirring, then slowly reduced to 190C reflux. The reaction was carried out over 5h with a running plate to follow the reaction (unfolding agent:chloroform:methanol:benzene=20:1:1 ; Rf=0.6). Cooling, distillation under reduced pressure and collection of (88-90)°C ( 18 mmHg) fraction gave the title compound. The compound was a colorless liquid, b p : 188-189C, refractive index: 1.549, d 1.053 , yield: (70%).
2,3-Dihydrobenzofuran Preparation Products And Raw materials
Raw materials
Preparation Products
1of3
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Weifang QianJin Fine Chemical Co., Ltd. | 18753684562 | 1577399715@qq.COM | China | 1772 | 55 |
| AgileBioChem Co., Ltd. | 0555-18055517827 18055517827 | sales@agilebiochem.com | China | 997 | 50 |
| Shandong Vantage Specialty Chemicals Biotechnology Co., Ltd. | 13396369453 18678026865 | sdfantai@163.com | China | 904 | 58 |
| Jinan Kangluoyuan Trading Co., Ltd | 13953193998 18366183150 | 287973232@qq.com | China | 19 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| INTATRADE GmbH | +49 3493/605464 | sales@intatrade.de | Germany | 3563 | 66 |
| Bridge Organics | +1269-649-4200 | ab@bridgeorganics.com | United States | 160 | 55 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
View Lastest Price from 2,3-Dihydrobenzofuran manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-07 | 2,3-Dihydrobenzofuran
496-16-2
|
$20.00-30.00 | 1KG | 99% | 3000KG | Shaanxi Dideu Medichem Co. Ltd | |
 |
2026-07-27 | Coumaran
496-16-2
|
$29.00 | 98.64% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-07-27 | Coumaran
496-16-2
|
$29.00 | 98.64% | 10g | TargetMol Chemicals Inc. |
-
- 2,3-Dihydrobenzofuran
496-16-2
- $20.00-30.00
- 99%
- Shaanxi Dideu Medichem Co. Ltd
-
- Coumaran
496-16-2
- $29.00
- 98.64%
- TargetMol Chemicals Inc.
-
- Coumaran
496-16-2
- $29.00
- 98.64%
- TargetMol Chemicals Inc.
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